Department Brüning

Journal Article (185)

2017
Journal Article
Jais, A.; Brüning, J. C.: Hypothalamic inflammation in obesity and metabolic disease. The Journal of Clinical Investigation 127 (1), pp. 24 - 32 (2017)
Journal Article
Layer, J. P.; Kronmüller, M. T.; Quast, T.; van den Boorn-Konijnenberg, D.; Effern, M.; Hinze, D.; Althoff, K.; Schramm, A.; Westermann, F.; Peifer, M. et al.; Hartmann, G.; Tüting, T.; Kolanus, W.; Fischer, M.; Schulte, J. H.; Hölzel, M.: Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. Oncoimmunology 6 (3), e1320626 (2017)
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Lechner, A.; Schlößer, H.; Rothschild, S. I.; Thelen, M.; Reuter, S.; Zentis, P.; Shimabukuro-Vornhagen, A.; Theurich, S.; Wennhold, K.; Garcia-Marquez, M. et al.; Tharun, L.; Quaas, A.; Schauss, A.; Isensee, J.; Hucho, T.; Huebbers, C.; von Bergwelt-Baildon, M.; Beutner, D.: Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma. Oncotarget 8 (27), pp. 44418 - 44433 (2017)
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Lodrini, M.; Sprüssel, A.; Astrahantseff, K.; Tiburtius, D.; Konschak, R.; Lode, H. N.; Fischer, M.; Keilholz, U.; Eggert, A.; Deubzer, H. E.: Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma. Oncotarget 8 (49), pp. 85234 - 85251 (2017)
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Loh, K.; Zhang, L.; Brandon, A.; Wang, Q.; Begg, D.; Qi, Y.; Fu, M.; Kulkarni, R.; Teo, J.; Baldock, P. et al.; Brüning, J. C.; Cooney, G.; Neely, G. G.; Herzog, H.: Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism 6 (6), pp. 574 - 584 (2017)
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Paeger, L.; Karakasilioti, I.; Altmueller, J.; Frommole, P.; Brüning, J. C.; Kloppenburg, P.: Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife 6, e25770 (2017)
Journal Article
Paeger, L.; Pippow, A.; Hess, S.; Paehler, M.; Klein, A. C.; Husch, A.; Pouzat, C.; Brüning, J. C.; Kloppenburg, P.: Energy imbalance alters Ca2+ handling and excitability of POMC neurons. eLife 6, e25641 (2017)
Journal Article
Pereira, M.; Mahu, I.; Seixas, E.; Martinez-Sanchez, N.; Kubasova, N.; Pirzgalska, R. M.; Cohen, P.; Dietrich, M. O.; Lopez, M.; Bernardes, G. J. et al.; Domingos, A. I.: A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Communications 8, 14967 (2017)
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Pir, G. J.; Choudhary, B.; Mandelkow, E.: Caenorhabditis elegans models of tauopathy. The FASEB Journal 31 (12), pp. 5137 - 5148 (2017)
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Ponomarenko, A.; Korotkova, T.: To eat? To sleep? To run? Coordination of innate behaviors by lateral hypothalamus. Neuroforum 23 (2), pp. A45 - A55 (2017)
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Rao, S.; Sigl, V.; Wimmer, R. A.; Novatchkova, M.; Jais, A.; Wagner, G.; Handschuh, S.; Uribesalgo, I.; Hagelkruys, A.; Kozieradzki, I. et al.; Tortola, L.; Nitsch, R.; Cronin, S. J.; Orthofer, M.; Branstetter, D.; Canon, J.; Rossi, J.; D'Arcangelo, M.; Botling, J.; Micke, P.; La Fleur, L.; Edlund, K.; Bergqvist, M.; Ekman, S.; Lendl, T.; Popper, H.; Takayanagi, H.; Kenner, L.; Hirsch, F. R.; Dougall, W.; Penninger, J.: RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes and Development 31 (20), pp. 2099 - 2112 (2017)
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Riera, C. E.; Tsaousidou, E.; Halloran, J.; Follett, P.; Hahn, O.; Pereira, M.; Ruud, L. E.; Alber, J.; Tharp, K.; Anderson, C. M. et al.; Brönneke, H. S.; Hampel, B.; de Magalhaes Filho, C. D.; Stahl, A.; Brüning, J. C.; Dillin, A.: The sense of smell impacts metabolic health and obesity. Cell Metabolism 26 (1), pp. 198 - 211 (2017)
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Ruud, J.; Steculorum, S. M.; Brüning, J. C.: Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nature Communications 8, 15259 (2017)
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Schommers, P.; Thurau, A.; Bultmann-Mellin, I.; Guschlbauer, M.; Klatt, A. R.; Rozman, J.; Klingenspor, M.; Hrabe de Angelis, M.; Alber, J.; Gründemann, D. et al.; Sterner-Kock, A.; Wiesner, R. J.: Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state. Molecular Metabolism 6 (7), pp. 737 - 747 (2017)
Journal Article
Seelig, E.; Meyer, S.; Timper, K.; Nigro, N.; Bally, M.; Pernicova, I.; Schuetz, P.; Müller, B.; Korbonits, M.; Christ-Crain, M.: Metformin prevents metabolic side effects during systemic glucocorticoid treatment. European Journal of Endocrinology 176 (3), pp. 349 - 358 (2017)
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Steculorum, S. M.; Timper, K.; Engström Ruud, L.; Evers, N.; Paeger, L.; Bremser, S.; Kloppenburg, P.; Brüning, J. C.: Inhibition of P2Y6 signaling in AgRP neurons reduces food intake and improves systemic insulin sensitivity in obesity. Cell Reports 18 (7), pp. 1587 - 1597 (2017)
Journal Article
Theurich, S.; Tsaousidou, E.; Hanssen, R.; Lempradl, A. M.; Mauer, J.; Timper, K.; Schilbach, K.; Folz-Donahue, K.; Heilinger, C.; Sexl, V. et al.; Pospisilik, J. A.; Wunderlich, F. T.; Brüning, J. C.: IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis. Cell Metabolism 26 (1), pp. 171 - 184 (2017)
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Timper, K.; Brüning, J. C.: Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Disease Models and Mechanisms 10 (6), pp. 679 - 689 (2017)
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Timper, K.; Denson, J. L.; Steculorum, S. M.; Heilinger, C.; Engström-Ruud, L.; Wunderlich, C. M.; Rose-John, S.; Wunderlich, F. T.; Brüning, J. C.: IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling. Cell Reports 19 (2), pp. 267 - 280 (2017)
Journal Article
Wennhold, K.; Weber, T. M.; Klein-Gonzalez, N.; Thelen, M.; Garcia-Marquez, M. A.; Chakupurakal, G.; Fiedler, A.; Schlößer, H.; Fischer, R.; Theurich, S. et al.; Shimabukuro-Vornhagen, A.; von Bergwelt-Baildon, M.: CD40-activated B cells induce anti-tumor immunity in vivo. Oncotarget 8 (17), pp. 27740 - 27253 (2017)
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