Publications

Cheng, Y.; Luo, H.; Izzo, F.; Pickering, B. F.; Nguyen, D.; Myers, R.; Schurer, A.; Gourkanti, S.; Brüning, J. C.; Vu, L. P. et al.; Landau, D. A.; Kharas, M. G.: m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment. Cell Reports 28 (7), pp. P1703 - P1716.e6 (2019)

Edwin Thanarajah, S.; Iglesias, S.; Kuzmanovic, B.; Rigoux, L.; Stephan, K. E.; Brüning, J. C.; Tittgemeyer, M.: Modulation of midbrain neurocircuitry by intranasal insulin. NeuroImage 194, pp. 120 - 127 (2019)

Hammerschmidt, P.; Ostkotte, D.; Nolte, H.; Gerl, M. J.; Jais, A.; Brunner, H. L.; Sprenger, H.-G.; Awazawa, M.; Nicholls, H. T.; Turpin-Nolan, S. M. et al.; Langer, T.; Krüger, M.; Brügger, B.; Brüning, J. C.: CerS6-derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity. Cell 177 (6), pp. 1536 - 1552.e23 (2019)

Ip, C. K.; Zhang, L.; Farzi, A.; Qi, Y.; Clarke, I.; Reed, F.; Shi, Y.-C.; Enriquez, R.; Dayas , C.; Graham, B. et al.; Begg, D.; Brüning, J. C.; Lee, N. J.; Hernandez-Sanchez, D.; Gopalasingam, G.; Koller, J.; Tasan, R.; Sperk, G.; Herzog, H.: Amygdala NPY circuits promote the development of accelerated obesity under chronic stress conditions. Cell Metabolism 30 (1), pp. 111 - 128.e6 (2019)

Koach, J.; Holien, J. K.; Massudi, H.; Carter, D. R.; Ciampa, O. C.; Herath, M.; Lim, T.; Seneviratne, J. A.; Milazzo, G.; Murray, J. E. et al.; McCarroll, J. A.; Liu, B.; Mayoh, C.; Keenan, B.; Stevenson, B. W.; Gorman, M. A.; Bell, J. L.; Doughty, L.; Hüttelmaier, S.; Oberthuer, A.; Fischer, M.; Gifford, A. J.; Liu, T.; Zhang, X.; Zhu, S.; Gustafson, W. C.; Haber, M.; Norris, M. D.; Fletcher, J. I.; Perini, G.; Parker, M. W.; Cheung, B. B.; Marshall, G. M.: Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface. Cancer Research: an official organ of the American Association for Cancer Research 79 (21), pp. 5652 - 5667 (2019)

Lippert, R. N.; Cremer, A. L.; Thanarajah, S. E.; Korn, C.; Jahans-Price, T.; Burgeno, L. M.; Tittgemeyer, M.; Brüning, J. C.; Walton, M. E.; Backes, H.: Time-dependent assessment of stimulus-evoked regional dopamine release. Nature Communications 10 (1), 336 (2019)

MacVicar, T.; Ohba, Y.; Nolte, H.; Mayer, F. C.; Tatsuta, T.; Sprenger, H.-G.; Lindner, B.; Zhao, Y.; Li, J.; Bruns, C. et al.; Krüger, M.; Habich, M.; Riemer, J.; Schwarzer, R.; Pasparakis, M.; Henschke, S.; Brüning, J. C.; Zamboni, N.; Langer, T.: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature 575 (7782), pp. 361 - 365 (2019)

Ostermann, A. L.; Wunderlich, C. M.; Schneiders, L.; Vogt, M. C.; Woeste, M.A.; Belgardt, B. F.; Niessen, C. M.; Martiny, B.; Schauss, A. C.; Frommolt, P. et al.; Nikolaev, A.; Hövelmeyer, N.; Sears, R.C.; Koch, P.J.; Günzel, D.; Brüning, J. C.; Wunderlich, F. T.: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nature Metabolism 1 (3), pp. 371 - 389 (2019)

Pelzer, E. A.; Melzer, C.; Schönberger, A. R.; Heß, M. E.; Timmermann, L.; Eggers, C.; Tittgemeyer, M.: Axonal degeneration in Parkinson's disease – Basal ganglia circuitry and D2 receptor availability. NeuroImage: Clinical 23, 101906 (2019)

Pir, G. J.; Choudhary, B.; Kaniyappan, S.; Chandupatla, R. R.; Mandelkow, E.; Mandelkow, E.-M.; Wang, Y.: Suppressing Tau aggregation and toxicity by an anti-aggregant Tau fragment. Molecular Neurobiology 56 (5), pp. 3751 - 3767 (2019)

Raichur, S.; Brunner, B.; Bielohuby, M.; Hansen, G.; Pfenninger, A.; Wang, B.; Brüning, J. C.; Larsen, P. J.; Tennagels, N.: The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach. Molecular Metabolism 21, pp. 36 - 50 (2019)

Rao, S.; Mondragón, L.; Pranjic, B.; Hanada, T.; Stoll, G.; Köcher, T.; Zhang, P.; Jais, A.; Lercher, A.; Bergthaler, A. et al.; Schramek, D.; Haigh, K.; Sica, V.; Leduc, M.; Modjtahedi, N.; Pai, T.-P.; Onji, M.; Uribesalgo, I.; Hanada, R.; Kozieradzki, I.; Koglgruber, R.; Cronin, S. J.; She, Z.; Quehenberger, F.; Popper, H.; Kenner, L.; Haigh, J. J.; Kepp, O.; Rak, M.; Cai, K.; Kroemer, G.; Penninger, J.: AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Research 29 (7), pp. 579 - 591 (2019)

Ruud, J.; Alber, J.; Tokarska, A.; Engström Ruud, L.; Nolte, H.; Biglari, N.; Lippert, R. N.; Lautenschlager, Ä.; Cieslak, P. E.; Szumiec, L. et al.; Hess, M. E.; Brönneke, H. S.; Krüger, M.; Nissbrandt, H.; Korotkova, T.; Silberberg, G.; Rodriguez Parkitna, J.; Brüning, J. C.: The Fat mass and obesity-associated protein (FTO) regulates locomotor responses to novelty via D2R medium spiny neurons. Cell Reports 27 (11), pp. 3182 - 3198.e9 (2019)

Thanarajah, S. E.; Backes, H.; DiFeliceantonio, A.; Albus, K.; Cremer, A. L.; Hanssen, R.; Lippert, R. N.; Cornely, O. A.; Small, D. M.; Brüning, J. C. et al.; Tittgemeyer, M.: Food intake recruits orosensory and post-ingestive dopaminergic circuits to affect eating desire in humans. Cell Metabolism 29 (3), pp. 695 - 706.e4 (2019)

Thanarajah, S. E.; Hoffstall, V.; Rigoux, L.; Hanssen, R.; Brüning, J. C.; Tittgemeyer, M.: The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Scientific Reports 9, 7222 (2019)

Turpin-Nolan, S. M.; Hammerschmidt, P.; Chen, W.; Jais, A.; Timper, K.; Awazawa, M.; Brodesser, S.; Brüning, J. C.: CerS1-derived C18:0 ceramide in skeletal muscle promotes obesity-induced insulin resistance. Cell Reports 26 (1), pp. 1 - 10.e7 (2019)

Wang, L.; De Solis, A. J.; Goffer, Y.; Birkenbach, K. E.; Engle, S. E.; Tanis, R.; Levenson, J. M.; Lie, X.; Rausch, R.; Purohit, M. et al.; Lee, J.-Y.; Tan, J.; De Rosa, M. C.; Doege, C. A.; Aaron, H. L.; Martins, G. J.; Brüning, J. C.; Egli, D.; Costa, R.; Berbari, N.; Leibel, R. L.; Stratigopoulos, G.: Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight 4, e123337 (2019)