Publications of Sophie Marie Steculorum

Ardanaz, C. G.; Steculorum, S. M.: Two-for-one candidate drug to tackle obesity. Nature (accepted)

Decoster, L.; Trova, S.; Zucca, S.; Bulk, J.; Gouveia, A.; Ternier, G.; Lhomme, T.; Legrand, A.; Gallet, S.; Boehm, U. et al.; Wyatt, A.; Wahl, V.; Wartenberg, P.; Hrabovszky, E.; Racz, G.; Luzzati, F.; Nato, G.; Fogli, M.; Peretto, P.; Schriever, S. C.; Bernecker, M.; Pfluger, P. T.; Steculorum, S. M.; Bovetti, S.; Rasika, S.; Prevot, V.; Silva, M. S.B.; Giacobini, P.: A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice. Nature Neuroscience 27 (9), pp. 1758 - 1773 (2024)

Paß, T.; Ricke, K. M.; Hofmann, P.; Chowdhury, R. S.; Nie, Y.; Chinnery, P.; Endepols, H.; Neumaier, B.; Carvalho, A.; Rigoux, L. et al.; Steculorum, S. M.; Prudent, J.; Riemer, T.; Aswendt, M.; Liss, B.; Brachvogel, B.; Wiesner, R. J.: Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons. Brain 147 (9), pp. 3189 - 3203 (2024)

Hammerschmidt, P.; Steculorum, S. M.; Bandet, C. L.; Del Rio-Martin, A.; Steuernagel, L.; Kohlhaas, V.; Feldmann, M.; Varela, L.; Majcher, A.; Quatorze Correia, M. et al.; Klar, R. F.U.; Bauder, C. A.; Kaya, E.; Porniece, M.; Biglari, N.; Sieben, A.; Horvath, T. L.; Hornemann, T.; Brodesser, S.; Brüning, J. C.: CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications 14 (1), 7824 (2023)

Hanssen, R.; Rigoux, L.; Albus, K.; Kretschmer, A. C.; Thanarajah, S. E.; Chen, W. Y.; Hinze, Y.; Giavalisco, P.; Steculorum, S. M.; Cornely, O. A. et al.; Brüning, J. C.; Tittgemeyer, M.: Circulating uridine dynamically and adaptively regulates food intake in humans. Cell Reports Medicine 4 (1), 100897 (2023)

Gouveia, A.; de Oliveira Beleza, R.; Steculorum, S. M.: AgRP neuronal activity across feeding-related behaviours. The European journal of neuroscience (10), pp. 7458 - 7475 (2021)

Pujol, C.; Legrand, A.; Parodi, L.; Thomas, P.; Mochel, F.; Saracino, D.; Coarelli, G.; Croon, M.; Popovic, M.; Valet, M. et al.; Villain, N.; Elshafie, S.; Issa, M.; Zuily, S.; Renaud, M.; Marelli-Tosi, C.; Legendre, M.; Trimouille, A.; Kemlin, I.; Mathieu, S.; Gleeson, J. G.; Lamari, F.; Galatolo, D.; Alkouri, R.; Tse, C.; Rodriguez, D.; Ewenczyk, C.; Fellmann, F.; Kuntzer, T.; Blond, E.; El Hachimi, K. H.; Darios, F.; Seyer, A.; Gazi, A. D.; Giavalisco, P.; Perin, S.; Boucher, J.-L.; Le Corre, L.; Santorelli, F. M.; Goizet, C.; Zaki, M. S.; Picaud, S.; Mourier, A.; Steculorum, S. M.; Mignot, C.; Durr, A.; Trifunovic, A.; Stevanin, G.: Implication of folate deficiency in CYP2U1 loss of function. Journal of Experimental Medicine 218 (11), e20210846 (2021)

Ruud, J.; Steculorum, S. M.; Brüning, J. C.: Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nature Communications 8, 15259 (2017)

Steculorum, S. M.; Timper, K.; Engström Ruud, L.; Evers, N.; Paeger, L.; Bremser, S.; Kloppenburg, P.; Brüning, J. C.: Inhibition of P2Y6 signaling in AgRP neurons reduces food intake and improves systemic insulin sensitivity in obesity. Cell Reports 18 (7), pp. 1587 - 1597 (2017)

Timper, K.; Denson, J. L.; Steculorum, S. M.; Heilinger, C.; Engström-Ruud, L.; Wunderlich, C. M.; Rose-John, S.; Wunderlich, F. T.; Brüning, J. C.: IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling. Cell Reports 19 (2), pp. 267 - 280 (2017)

Jais, A.; Solas, M.; Backes, H.; Chaurasia, B.; Kleinridders, A.; Theurich, S.; Mauer, J.; Steculorum, S. M.; Hampel, B.; Goldau, J. et al.; Alber, J.; Förster, C. Y.; Eming, S. A.; Schwaninger, M.; Ferrara, N.; Karsenty, G.; Brüning, J. C.: Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165 (4), pp. 882 - 895 (2016)

Steculorum, S. M.; Brüning, J. C.: Sweet mitochondrial dynamics in VMH neurons. Cell Metabolism 23 (4), pp. 577 - 579 (2016)

Steculorum, S. M.; Ruud, J.; Karakasilioti, I.; Backes, H.; Engström Ruud, L.; Timper, K.; Heß, M. E.; Tsaousidou, E.; Mauer, J.; Vogt, M. C. et al.; Paeger, L.; Bremser, S.; Klein, A. C.; Morgan, D. A.; Frommolt, P.; Brinkkötter, P. T.; Hammerschmidt, P.; Benzing, T.; Rahmouni, K.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue. Cell 165 (1), pp. 125 - 138 (2016)

Steculorum, S. M.; Collden, G.; Coupe, B.; Croizier, S.; Lockie, S.; Andrews, Z. B.; Jarosch, F.; Klussmann, S.; Bouret, S. G.: Neonatal ghrelin programs development of hypothalamic feeding circuits. The Journal of clinical investigation (2), pp. 846 - 858 (2015)

Steculorum, S. M.; Paeger, L.; Bremser, S.; Evers, N.; Hinze, Y.; Idzko, M.; Kloppenburg, P.; Brüning, J. C.: Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP neurons. Cell 162 (6), pp. 1404 - 1417 (2015)

Steculorum, S. M.; Brüning, J. C.: Die another day: A painless path to longevity. Cell 157 (5), pp. 1004 - 1006 (2014)

Steculorum, S. M.; Solas, M.; Brüning, J. C.: The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimer's and Dementia 10 (1, Suppl.), pp. S3 - S11 (2014)

Vogt, M. C.; Paeger, L.; Hess, S.; Steculorum, S. M.; Awazawa, M.; Hampel, B.; Neupert, S.; Nicholls, H. T.; Mauer, J.; Hausen, A. C. et al.; Predel, R.; Kloppenburg, P.; Horvath, T. L.; Brüning, J. C.: Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell 156 (3), pp. 495 - 509 (2014)

Steculorum, S. M.; Vogt, M. C.; Brüning, J. C.: Perinatal programming of metabolic diseases. Role of insulin in the development of hypothalamic neurocircuits. Endocrinology and Metabolism Clinics of North America 42 (1), pp. 149 - 164 (2013)

Steculorum, S. M.; Bouret, S. G.: Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology (11), pp. 4171 - 4179 (2011)