Publications

Kaul, H.; Isermann, L.; Senft, K.; Popovic, M.; Georgomanolis, T.; Baumann, L.; Sivanesan, P.; Pouikli, A.; Nolte, H.; Lucic, B. et al.; Hildebrandt, X.; Seidel, K.; Gnad, T.; Gaedke, F.; Göbel, U.; Peters, F.; Cherevatenko, M.; Park, J. H.; Schauss, A.; Peltzer, N.; Brüning, J. C.; Kornfeld, J.-W.; Pfeifer, A.; Langer, T.; Lusic, M.; Wickström, S. A.; Frezza, C.; Trifunovic, A.: 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nature Metabolism 7, pp. 1593 - 1613 (2025)

Hof, A.; Landerer, M.; Peitsmeyer, P.; Herzog, R.; Alber, J.; Ahdab, M.; Nettersheim, F. S.; Mehrkens, D.; Geißen, S.; Braumann, S. et al.; Guthoff, H.; von Stein, P.; Nemade, H.; Picard, F. S. R.; Braun, R.; Hoyer, F. F.; Brüning, J. C.; Pfeifer, A.; Hildebrand, S.; Winkels, H.; Baldus, S.; Adam, M.; Schäkel, J.; Mollenhauer, M.: Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Reports Medicine 6, 102087, p. 102087 (2025)

Izawa, S.; Fusca, D.; Jiang, H.; Heilinger, C.; Hausen, A. C.; Wunderlich, F. T.; Steuernagel, L.; Kloppenburg, P.; Brüning, J. C.: Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity. Cell Reports 44, 115277, p. 115277 (2025)

Jiao, Z.; Gao, T.; Wang, X.; Wang, A.; Ma, Y.; Feng, L.; Gao, L.; Gou, L.; Zhang, W.; Biglari, N. et al.; Boxer, E. E.; Steuernagel, L.; Ding, X.; Yu, Z.; Li, M.; Gao, M.; Hao, M.; Zhou, H.; Cao, X.; Li, S.; Jiang, T.; Qi, J.; Jia, X.; Feng, Z.; Ren, B.; Chen, Y.; Shi, X.; Wang, D.; Wang, X.; Han, L.; Liang, Y.; Qian, L.; Jin, C.; Huang, J.; Deng, W.; Wang, C.; Li, E.; Hu, Y.; Tao, Z.; Li, H.; Yu, X.; Xu, M.; Chang, H.-C.; Zhang, Y.; Xu, H.; Yan, J.; Li, A.; Luo, Q.; Stoop, R.; Sternson, S. M.; Brüning, J. C.; Anderson, D. J.; Poo, M.-m.; Sun, Y.; Xu, S.; Gong, H.; Sun, Y.-G.; Xu, X.: Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nature Neuroscience 28, pp. 1073 - 1088 (2025)

Puente-Ruiz, S. C.; Ide, L.; Schuller, J.; Ben-Kraiem, A.; Hoffmann, A.; Ghosh, A.; Noé, F.; Wolfrum, C.; Krause, K.; Gericke, M. et al.; Klöting, N.; Brüning, J. C.; Wunderlich, F. T.; Blüher, M.; Jais, A.: B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity. iScience 28, 112819, p. 112819 (2025)

Solheim, M. H.; Stroganov, S.; Chen, W.; Subagia, P. S.; Bauder, C. A.; Wnuk-Lipinski, D.; Del Río-Martín, A.; Sotelo-Hitschfeld, T.; Beddows, C. A.; Klemm, P. et al.; Dodd, G. T.; Lundh, S.; Secher, A.; Wunderlich, F. T.; Steuernagel, L.; Brüning, J. C.: Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis. Cell 188, pp. 3550 - 3566.e22 (2025)

Tadross, J. A.; Steuernagel, L.; Dowsett, G. K. C.; Kentistou, K. A.; Lundh, S.; Porniece, M.; Klemm, P.; Rainbow, K.; Hvid, H.; Kania, K. et al.; Polex-Wolf, J.; Knudsen, L. B.; Pyke, C.; Perry, J. R. B.; Lam, B. Y. H.; Brüning, J. C.; Yeo, G. S. H.: A comprehensive spatio-cellular map of the human hypothalamus. Nature 639, pp. 708 - 716 (2025)

Tadross, J. A.; Steuernagel, L.; Dowsett, G. K. C.; Kentistou, K. A.; Lundh, S.; Porniece, M.; Klemm, P.; Rainbow, K.; Hvid, H.; Kania, K. et al.; Polex-Wolf, J.; Knudsen, L. B.; Pyke, C.; Perry, J. R. B.; Lam, B. Y. H.; Brüning, J. C.; Yeo, G. S. H.: Author Correction: A comprehensive spatio-cellular map of the human hypothalamus. Nature 639, p. E17 - E17 (2025)

Zhu, Y.; Mehlkop, O.; Backes, H.; Cremer, A. L.; Porniece, M.; Klemm, P.; Steuernagel, L.; Chen, W.; Johnen, R.; Wunderlich, F. T. et al.; Jais, A.; Brüning, J. C.: Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling. Cell Reports 44, 115522, p. 115522 (2025)

Altafi, M.; Chen, C.; Korotkova, T.; Ponomarenko, A.: Sequential Activation of Lateral Hypothalamic Neuronal Populations during Feeding and Their Assembly by Gamma Oscillations. The Journal of Neuroscience 44 (43), e0518242024 (2024)

Amatruda, M.; Marechal, D.; Gacias, M.; Wentling, M.; Turpin-Nolan, S. M.; Morstein, J.; Moniruzzaman, M.; Brüning, J. C.; Haughey, N. J.; Trauner, D. H. et al.; Casaccia, P.: Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia, pp. 1 - 20 (2024)

Ardanaz, C. G.; de la Cruz, A.; Minhas, A.; Hernandez-Martin, N.; Pozo, M. A.; Valdecantos, M. P.; Valverde, A. M.; Villa-Valverde, P.; Elizalde-Horcada, M.; Puerta, E. et al.; Ramirez, M. J.; Ortega, J. E.; Urbiola, A.; Ederra, C.; Ariz, M.; Ortiz-De-Solorzano, C.; Fernandez-Irigoyen, J.; Santamaria, E.; Karsenty, G.; Brüning, J. C.; Solas, M.: Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances 10 (42), eadp1115 (2024)

Chen, C.; Altafi, M.; Corbu, M.-A.; Trenk, A.; Van den Munkhof, H. E.; Weineck, K.; Bender, F.; Carus-Cadavieco, M.; Bakhareva, A.; Korotkova, T. et al.; Ponomarenko, A.: The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions. Nature Neuroscience 27 (5), pp. 952 - 963 (2024)

de Solis, A. J.; Del Rio-Martin, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A. L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 6 (3), pp. 473 - 493 (2024)

Dodt, S.; Widdershooven, N. V.; Dreisow, M.-L.; Weiher, L.; Steuernagel, L.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 15 (1), 5439 (2024)

Engström Ruud, L.; Font-Gironès, F.; Zajdel, J.; Kern, L.; Teixidor-Deulofeu, J.; Manneras-Holm, L.; Carreras, A.; Becattini, B.; Björefeldt, A.; Hanse, E. et al.; Fenselau, H.; Solinas, G.; Brüning, J. C.; Wunderlich, F. T.; Bäckhed, F.; Ruud, J.: Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Reports 43 (4), 113960 (2024)

Henschke, S.; Nolte, H.; Magoley, J.; Kleele, T.; Brandt, C.; Hausen, A. C.; Wunderlich, C. M.; Bauder, C.; Aschauer, P.; Manley, S. et al.; Langer, T.; Wunderlich, F. T.; Brüning, J. C.: Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science 384 (6694), pp. 438 - 446 (2024)

Leon, S.; Simon, V.; Lee, T. H.; Steuernagel, L.; Clark, S.; Biglari, N.; Lesté-Lassere, T.; Dupuy, N.; Cannich, A.; Bellocchio, L. et al.; Zizzari, P.; Allard, C.; Gonzales, D.; Le Feuvre, Y.; Lhuillier, E.; Brochard, A.; Nicolas, J. C.; Teillon, J.; Nikolski, M.; Marsicano, G.; Fioramonti, X.; Brüning, J. C.; Cota, D.; Quarta, C.: Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity. Nature Communications 15, 3443 (2024)

Sotelo-Hitschfeld, T.; Minère, M.; Klemm, P.; Borgmann, D.; Wnuk-Lipinski, D.; Jais, A.; Jia, X.; Corneliussen, S.; Kloppenburg, P.; Fenselau, H. et al.; Brüning, J. C.: GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Reports 43 (6), 114343 (2024)

Springer, C.; Binsch, C.; Weide, D.; Toska, L.; Cremer, A. L.; Backes, H.; Scheel, A. K.; Espelage, L.; Kotzka, J.; Sill , S. et al.; Kurowski, A.; Kim, D.; Karpinski, S.; Schnurr, T. M.; Hansen, T.; Hartwig, S.; Lehr, S.; Cames, S.; Brüning, J. C.; Lienhard, M.; Herwig, R.; Börno, S.; Timmermann, B.; Al-Hasani, H.; Chadt, A.: Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance. Diabetes 73 (7), pp. 1058 - 1071 (2024)