Publications

Chen, C.; Altafi, M.; Corbu, M.-A.; Trenk, A.; Van den Munkhof, H. E.; Weineck, K.; Bender, F.; Carus-Cadavieco, M.; Bakhareva, A.; Korotkova, T. et al.; Ponomarenko, A.: The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions. Nature Neuroscience (accepted)

de Solis, A. J.; Del Rio-Martin, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A. L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 6 (3), pp. 473 - 493 (2024)

Engström Ruud, L.; Font-Gironès, F.; Zajdel, J.; Kern, L.; Teixidor-Deulofeu, J.; Manneras-Holm, L.; Carreras, A.; Becattini, B.; Björefeldt, A.; Hanse, E. et al.; Fenselau, H.; Solinas, G.; Brüning, J. C.; Wunderlich, F. T.; Bäckhed, F.; Ruud, J.: Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Reports 43 (4), 113960 (2024)

Vossen, C.; Schmidt, P.; Wunderlich, C. M.; Mittenbühler, M. J.; Tapken, C.; Wienand, P.; Mirabella, P. N.; Cabot, L.; Schumacher, A.-L.; Folz-Donahue, K. et al.; Kukat, C.; Voigt, I.; Brüning, J. C.; Fenselau, H.; Wunderlich, F. T.: An approach to intersectionally target mature enteroendocrine cells in the small intestine of mice. Cells 13 (1), 102 (2024)

Brüning, J. C.; Fenselau, H.: Integrative neurocircuits that control metabolism and food intake. Science 381 (6665), eabl7398 (2023)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35 (5), pp. 786 - 806.e13 (2023)

Edwin Thanarajah, S.; DiFeliceantonio, A.; Albus, K.; Kuzmanovic, B.; Rigoux, L.; Iglesias, S.; Hanßen, R.; Schlamann, M.; Cornely, O. A.; Brüning, J. C. et al.; Tittgemeyer, M.; Small, D. M.: Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. Cell Metabolism 35 (4), pp. 571 - 584.e6 (2023)

Griess, K.; Rieck, M.; Müller, N.; Karsai, G.; Hartwig, S.; Pelligra, A.; Hardt, R.; Schlegel, C.; Kuboth, J.; Uhlemeyer, C. et al.; Trenkamp, S.; Jeruschke, K.; Weiss, J.; Peifer-Weiss, L.; Xu, W.; Cames, S.; Yi, X.; Cnop, M.; Beller, M.; Stark, H.; Kondadi, A. K.; Reichert, A. S.; Markgraf, D.; Wammers, M.; Häussinger, D.; Kuss, O.; Lehr, S.; Eizirik, D.; Lickert, H.; Lammert, E.; Roden, M.; Winter, D.; Al-Hasani, H.; Höglinger, D.; Hornemann, T.; Brüning, J. C.; Belgardt, B.-F.: Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature Cell Biology 25 (1), pp. 20 - 29 (2023)

Hammerschmidt, P.; Steculorum, S. M.; Bandet, C. L.; Del Rio-Martin, A.; Steuernagel, L.; Kohlhaas, V.; Feldmann, M.; Varela, L.; Majcher, A.; Quatorze Correia, M. et al.; Klar, R. F.U.; Bauder, C. A.; Kaya, E.; Porniece, M.; Biglari, N.; Sieben, A.; Horvath, T. L.; Hornemann, T.; Brodesser, S.; Brüning, J. C.: CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications 14 (1), 7824 (2023)

Hanssen, R.; Rigoux, L.; Albus, K.; Kretschmer, A. C.; Thanarajah, S. E.; Chen, W. Y.; Hinze, Y.; Giavalisco, P.; Steculorum, S. M.; Cornely, O. A. et al.; Brüning, J. C.; Tittgemeyer, M.: Circulating uridine dynamically and adaptively regulates food intake in humans. Cell Reports Medicine 4 (1), 100897 (2023)

Hanßen, R.; Rigoux, L.; Kuzmanovic, B.; Iglesias, S.; Kretschmer, A. C.; Schlamann, M.; Albus, K.; Thanarajah, S. E.; Sitnikow, T.; Melzer, C. et al.; Cornely, O. A.; Brüning, J. C.; Tittgemeyer, M.: Liraglutide restores impaired associative learning in individuals with obesity. Nature Metabolism 5 (8), pp. 1352 - 1363 (2023)

Hune, T. L.K.; Mamone, S.; Schmidt, A. B.; Mahu, I.; D'Apolito, N.; Wiedermann, D.; Brüning, J. C.; Glöggler, S.: Hyperpolarized multi-organ spectroscopy of liver and brain using 1-C-13-pyruvate enhanced via parahydrogen. Applied Magnetic Resonance 54 (11-12), pp. 1283 - 1295 (2023)

Norberto, S.; Assalin, H. B.; Guadagnini, D.; Tobar, N.; Boer, P. A.; Kang, M.-C.; Saad, M. J. A.; Kim, Y.-B.; Prada, P. O. d.: CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion. Frontiers in Endocrinology 14, 1172835 (2023)

Oliveira Ferreira, C. K. d.; Campolim, C. M.; Zordao, O. P.; Simabuco, F. M.; Anaruma, C. P.; Pereira, R. M.; Boico, V. F.; Salvino, L. G.; Costa, M. M.; Ruiz, N. Q. et al.; de Moura, L. P.; Saad, M. J. A.; Costa, S. K. P.; Kim, Y.-B.; Prada, P. O. d.: Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4. Toxicology Reports 11, pp. 10 - 22 (2023)

Parra-Vargas, M.; Bouret, S. G.; Brüning, J. C.; de Moura, E. G.; Garland, T.; Lisboa, P. C.; Ozanne, S. E.; Patti, M.-E.; Plagemann, A.; Speakman, J. R. et al.; Tena-Sempere, M.; Vergely, C.; Zeltser, L. M.; Jiménez-Chillarón, J. C.: The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Molecular Metabolism 71, 101707 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Hammerschmidt, P.; Brüning, J. C.: Contribution of specific ceramides to obesity-associated metabolic diseases. Cellular and Molecular Life Sciences 79 (8), 395 (2022)

Hanssen, R.; Thanarajah, S. E.; Tittgemeyer, M.; Brüning, J. C.: Obesity - A Matter of Motivation? Experimental and Clinical Endocrinology & Diabetes 130 (5), pp. 290 - 295 (2022)

Hoyer-Allo, K. J. R.; Späth, M. R.; Brodesser, S.; Zhu, Y.; Binz-Lotter, J.; Höhne, M.; Brönneke, H. S.; Bohl, K.; Johnsen, M.; Kubacki, T. et al.; Kiefer, K.; Seufert, L.; Koehler, F. C.; Grundmann, F.; Hackl, M. J.; Schermer, B.; Brüning, J. C.; Benzing, T.; Burst, V.; Müller, R. U.: Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury. Kidney International 102 (3), pp. 560 - 576 (2022)

Jais, A.; Brüning, J. C.: Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocrine Reviews 43 (2), pp. 314 - 328 (2022)