Publikationen von Frank Thomas Wunderlich

Cox, E.-M.; El-Behi, M.; Ries, S.; Vogt, J. F.; Kohlhaas, V.; Michna, T.; Manfroi, B.; Al-Maarri, M.; Wanke, F.; Tirosh, B. et al.; Pondarre, C.; Lezeau, H.; Yogev, N.; Mittenzwei, R.; Descatoire, M.; Weller, S.; Weill, J.-C.; Reynaud, C.-A.; Boudinot, P.; Jouneau, L.; Tenzer, S.; Distler, U.; Rensing-Ehl, A.; König, C.; Staniek, J.; Rizzi, M.; Magérus, A.; Rieux-Laucat, F.; Wunderlich, F. T.; Hövelmeyer, N.; Fillatreau, S.: AKT activity orchestrates marginal zone B cell development in mice and humans. Cell Reports 42 (4), 112378 (2023)

Flümann, R.; Hansen, J.; Pelzer, B. W.; Nieper, P.; Lohmann, T.; Kisis, I.; Riet, T.; Kohlhas, V.; Nguyen, P.-H.; Peifer, M. et al.; Abedpour, N.; Bosco, G.; Thomas, R. K.; Kochanek, M.; Knüfer, J.; Jonigkeit, L.; Beleggia, F.; Holzem, A.; Büttner, R.; Lohneis, P.; Meinel, J.; Ortmann, M.; Persigehl, T.; Hallek, M.; Calado, D. P.; Chmielewski, M.; Klein, S.; Göthert, J. R.; Chapuy, B.; Zevnik, B.; Wunderlich, F. T.; von Tresckow, B.; Jachimowicz, R. D.; Melnick, A. M.; Reinhardt, H. C.; Knittel, G.: Distinct genetically determined origins of Myd88/BCL2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies. Blood Cancer Discovery 4 (1), S. 78 - 97 (2023)

Nagao, H.; Cai, W.; Brandao, B. B.; Wewer Albrechtsen, N. J.; Steger, M.; Gattu, A. K.; Pan, H.; Dreyfuss, J. M.; Wunderlich, F. T.; Mann, M. et al.; Kahn, R. C.: Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. Journal of Clinical Investigation (New York, NY) 133 (4), e161472 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; von Koningsbruggen-Rietschel, S.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, F. T.; Priest, J.; Seeger, W.; Dötsch, J.; Pullamsetti, S. S.; Alejandre Alcazar, M. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nature Communications 13 (1), 4352 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Werr, L.; Plenker, D.; Dammert, M. A.; Lorenz, C.; Bragelmann, J.; Tumbrink, H. L.; Klein, S.; Schmitt, A.; Buttner, R.; Persigehl, T. et al.; Shokat, K. M.; Wunderlich, F. T.; Schram, A. M.; Peifer, M.; Sos, M. L.; Reinhardt, H. C.; Thomas, R. K.: CD74-NRG1 fusions are oncogenic in vivo and induce therapeutically tractable ERBB2:ERBB3 heterodimerization. Molecular Cancer Therapeutics 21 (5), S. 821 - 830 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), S. 913 - 929+ (2021)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), S. 1466 - 1482.e7 (2021)

Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hövelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Herling, C.; Hartmann, E. M.; Rosenwald, A.; Klapper, W.; Büttner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood 137 (5), S. 646 - 660 (2021)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, S. 1662 - 1679 (2021)

Peters, F.; Rahn, S.; Mengel, M.; Scharfenberg, F.; Otte, A.; Koudelka, T.; Wagner, E. F.; Wunderlich, F. T.; Haase, M.; Naumann, R. et al.; Tholey, A.; Becker-Pauly, C.: Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis. Matrix Biology 102, S. 37 - 69 (2021)

Schumacher, N.; Yan, K.; Gandraß, M.; Müller, M.; Krisp, C.; Häsler, R.; Carambia, A.; Nofer, J.-R.; Bernardes, J. P.; Khouja, M. et al.; Thomsen , I.; Chalupsky, K.; Bolik, J.; Hölscher, C.; Wunderlich, F. T.; Herkel, J.; Rosenstiel, P.; Schramm, C.; Schlüter, H.; Renné, T.; Mittrücker, H.-W.; Rose-John, S.; Schmidt-Arras, D.: Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice. Journal of Hepatology 74 (2), S. 407 - 418 (2021)

Xiao, X.; Yeghiazaryan, G.; Hess, S.; Klemm, P.; Sieben, A.; Kleinridders, A.; Morgan, D. A.; Wunderlich, F. T.; Rahmouni, K.; Kong, D. et al.; Scammell, T. E.; Lowell, B. B.; Kloppenburg, P.; Brüning, J. C.; Hausen, A. C.: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nature Communications 12, 5249 (2021)

Jais, A.; Paeger, L.; Sotelo-Hitschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J. M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, B. B.; Zeilhofer, H. U.; Backes, H.; Fenselau, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOC(ARC) Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron (6), S. 1009 - 1025.e10 (2020)

Jais, A.; Paeger, L.; Sotelo-Hitschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J.M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, B. B.; Zeilhofer, H. U.; Fenselau, H.; Backes, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106 (6), S. 1009 - 1025.e10 (2020)

Liedtke, K.; Alter, C.; Günther, A.; Hövelmeyer, N.; Klopfleisch, R.; Naumann, R.; Wunderlich, F. T.; Buer, J.; Westendorf, A. M.; Hansen, W.: Endogenous CD83 expression in CD4+ conventional T cells controls inflammatory immune responses. Journal of Immunology; American Association of Immunologists, Bethesda, USA 204 (12), S. 3217 - 3226 (2020)

Mehrjardi, N. Z.; Molcanyi, M.; Hatay, F. F.; Timmer, M.; Shahbazi, E.; Ackermann, J. P.; Herms, S.; Heilmann-Heimbach, S.; Wunderlich, F. T.; Prochnow, N. et al.; Haghikia, A.; Lampert, A.; Hescheler, J.; Neugebauer, E. A.M.; Baharvand, H.; Saric, T.: Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo. Cell Proliferation 53, e12892 (2020)

Mittenbühler, M.; Saedler, K.; Nolte, H.; Kern, L.; Zhou, J.; Qian, S.-B.; Meder, L.; Ullrich, R. T.; Brüning, J. C.; Wunderlich, F. T.: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Molecular Metabolism 42, 101085 (2020)

Mufazolov, I. A.; Andruszewski, D.; Schelmbauer, C.; Heink, S.; Blanfeld, M.; Masri, J.; Tang, Y.; Schüler, R.; Eich, C.; Wunderlich, F. T. et al.; Karbach, S. H.; Bluestone, J. A.; Korn, T.; Waisman, A.: Cutting edge: IL-6-driven immune dysregulation is strictly dependent on IL-6R a-chain expression. Journal of Immunology 204 (4), S. 747 - 751 (2020)