Publications of Frank Thomas Wunderlich

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; von Koningsbruggen-Rietschel, S.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, F. T.; Priest, J.; Seeger, W.; Dötsch, J.; Pullamsetti, S. S.; Alejandre Alcazar, M. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nature Communications 13 (1), 4352 (2022)

Werr, L.; Plenker, D.; Dammert, M. A.; Lorenz, C.; Bragelmann, J.; Tumbrink, H. L.; Klein, S.; Schmitt, A.; Buttner, R.; Persigehl, T. et al.; Shokat, K. M.; Wunderlich, F. T.; Schram, A. M.; Peifer, M.; Sos, M. L.; Reinhardt, H. C.; Thomas, R. K.: CD74-NRG1 fusions are oncogenic in vivo and induce therapeutically tractable ERBB2:ERBB3 heterodimerization. Molecular Cancer Therapeutics 21 (5), pp. 821 - 830 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), pp. 913 - 929+ (2021)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), pp. 1466 - 1482.e7 (2021)

Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hövelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Herling, C.; Hartmann, E. M.; Rosenwald, A.; Klapper, W.; Büttner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood 137 (5), pp. 646 - 660 (2021)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, pp. 1662 - 1679 (2021)

Peters, F.; Rahn, S.; Mengel, M.; Scharfenberg, F.; Otte, A.; Koudelka, T.; Wagner, E. F.; Wunderlich, F. T.; Haase, M.; Naumann, R. et al.; Tholey, A.; Becker-Pauly, C.: Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis. Matrix Biology 102, pp. 37 - 69 (2021)

Schumacher, N.; Yan, K.; Gandraß, M.; Müller, M.; Krisp, C.; Häsler, R.; Carambia, A.; Nofer, J.-R.; Bernardes, J. P.; Khouja, M. et al.; Thomsen , I.; Chalupsky, K.; Bolik, J.; Hölscher, C.; Wunderlich, F. T.; Herkel, J.; Rosenstiel, P.; Schramm, C.; Schlüter, H.; Renné, T.; Mittrücker, H.-W.; Rose-John, S.; Schmidt-Arras, D.: Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice. Journal of Hepatology 74 (2), pp. 407 - 418 (2021)

Xiao, X.; Yeghiazaryan, G.; Hess, S.; Klemm, P.; Sieben, A.; Kleinridders, A.; Morgan, D. A.; Wunderlich, F. T.; Rahmouni, K.; Kong, D. et al.; Scammell, T. E.; Lowell, B. B.; Kloppenburg, P.; Brüning, J. C.; Hausen, A. C.: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nature Communications 12, 5249 (2021)

Jais, A.; Paeger, L.; Sotelo-Hirschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J.M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, . B.; Zeilhofer, H. U.; Backes, H.; Fenselau, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106 (6), pp. 1009 - 1025.e10 (2020)

Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hoevelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Carmen, D. H.; Hartmann, E.; Rosenwald, A.; Klapper, W.; Buettner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood (2020)

Liedtke, K.; Alter, C.; Günther, A.; Hövelmeyer, N.; Klopfleisch, R.; Naumann, R.; Wunderlich, F. T.; Buer, J.; Westendorf, A. M.; Hansen, W.: Endogenous CD83 expression in CD4+ conventional T cells controls inflammatory immune responses. Journal of Immunology; American Association of Immunologists, Bethesda, USA 204 (12), pp. 3217 - 3226 (2020)

Mehrjardi, N. Z.; Molcanyi, M.; Hatay, F. F.; Timmer, M.; Shahbazi, E.; Ackermann, J. P.; Herms, S.; Heilmann-Heimbach, S.; Wunderlich, F. T.; Prochnow, N. et al.; Haghikia, A.; Lampert, A.; Hescheler, J.; Neugebauer, E. A.M.; Baharvand, H.; Saric, T.: Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo. Cell Proliferation 53, e12892 (2020)

Mittenbühler, M.; Saedler, K.; Nolte, H.; Kern, L.; Zhou, J.; Qian, S.-B.; Meder, L.; Ullrich, R. T.; Brüning, J. C.; Wunderlich, F. T.: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Molecular Metabolism 42, 101085 (2020)

Mufazolov, I. A.; Andruszewski, D.; Schelmbauer, C.; Heink, S.; Blanfeld, M.; Masri, J.; Tang, Y.; Schüler, R.; Eich, C.; Wunderlich, F. T. et al.; Karbach, S. H.; Bluestone, J. A.; Korn, T.; Waisman, A.: Cutting edge: IL-6-driven immune dysregulation is strictly dependent on IL-6R a-chain expression. Journal of Immunology 204 (4), pp. 747 - 751 (2020)

Riabinska, A.; Lehrmann, D.; Jachimowicz, R. D.; Knittel, G.; Fritz, C.; Schmitt, A.; Geyer, A.; Heneweer, C.; Wittersheim, M.; Frenzel, L. P. et al.; Torgovnick, A.; Wiederstein, J. L.; Wunderlich, C. M.; Ortmann, M.; Paillard, A.; Wößmann, W.; Borkhardt, A.; Burdach, S.; Hansmann, M.-L.; Rosenwald, A.; Perner, S.; Mall, G.; Klapper, W.; Merseburg, A.; Krüger, M.; Grüll, H.; Persigehl, T.; Wunderlich, F. T.; Peifer, M.; Utermöhlen, O.; Büttner, R.; Beleggia, F.; Reinhardt, H. C.: ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 34 (3), pp. 771 - 786 (2020)

Kern, L.; Mittenbühler, M.; Vesting, A. J.; Ostermann, A. L.; Wunderlich, C. M.; Wunderlich, F. T.: Obesity-induced TNF alpha and IL-6 signaling: The missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers 11 (1), 24 (2019)

Lahmann, I.; Bröhl, D.; Zyrianova, T.; Isomura, A.; Czajkowski, M. T.; Kapoor, V.; Griger, J.; Ruffault, P.-L.; Mademtzoglou, D.; Zammit, P. S. et al.; Wunderlich, F. T.; Spuler, S.; Kühn, R.; Preibisch, S.; Wolf, J.; Kageyama, R.; Birchmeier, C.: Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells. Genes and Development 33 (9-10), pp. 524 - 535 (2019)

Ostermann, A. L.; Wunderlich, C. M.; Schneiders, L.; Vogt, M. C.; Woeste, M.A.; Belgardt, B. F.; Niessen, C. M.; Martiny, B.; Schauss, A. C.; Frommolt, P. et al.; Nikolaev, A.; Hövelmeyer, N.; Sears, R.C.; Koch, P.J.; Günzel, D.; Brüning, J. C.; Wunderlich, F. T.: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nature Metabolism 1 (3), pp. 371 - 389 (2019)

Scherger, A. K.; Al-Maarri, M.; Maurer, H. C.; Schick, M.; Maurer, S.; Öllinger, R.; Gonzalez-Menendez, I.; Martella, M.; Thaler, M.; Pechloff, K. et al.; Steiger, K.; Sander, S.; Ruland, J.; Rad, R.; Quintanilla-Martinez, L.; Wunderlich, F. T.; Rose-John, S.; Keller, U.: Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma. JCI Insight 4 (15), e128435 (2019)