The design and function of endocrine systems follows an intrinsic logic that is not specific, but widely present in physiology. In my talk, I discuss homeostatic circuit designs at the intersection of endocrinology and immunology. I highlight examples that align with this regulatory principle and those that may not. I then address the potential connection between homeostatic control and inflammation and touch upon how I have applied this framework to one of my projects on cancer. I summarize my more recent findings on pharmacological manipulation of neuroendocrine control of leukocyte compartments that I approached from the same perspective, followed by a discussion of my observations in a broader context. Finally, I provide insights into fields that I am currently thinking about and actively pursuing, which have naturally emerged as a consequence of my scientific trajectory. I close my talk with concluding remarks and potential future avenues for scientific discovery.
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