Talk by Nikolai Jaschke, MD, PhD, Yale School of Medicine, USA

The design and function of endocrine systems follows an intrinsic logic that is not specific, but widely present in physiology. In my talk, I discuss homeostatic circuit designs at the intersection of endocrinology and immunology. I highlight examples that align with this regulatory principle and those that may not. I then address the potential connection between homeostatic control and inflammation and touch upon how I have applied this framework to one of my projects on cancer. I summarize my more recent findings on pharmacological manipulation of neuroendocrine control of leukocyte compartments that I approached from the same perspective, followed by a discussion of my observations in a broader context. Finally, I provide insights into fields that I am currently thinking about and actively pursuing, which have naturally emerged as a consequence of my scientific trajectory. I close my talk with concluding remarks and potential future avenues for scientific discovery.