Publikationen von Heiko Backes

de Solis, A. J.; Del Rio-Martin, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A. L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 6 (3), S. 473 - 493 (2024)

Binsch, C.; Barbosa, D.M.; Hansen-Dille, G.; Hubert, M.; Hodge, S.M.; Kolasa, M.; Jeruschke, K.; Weiss, J.; Springer, C.; Gorressen, S. et al.; Fischer, J.W.; Lienhard, M.; Herwig, R.; Boerno, S.; Timmermann, B.; Cremer, A. L.; Backes, H.; Chadt, A.; Al-Hasani, H.: Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion. Cardiovascular Diabetology 22 (1), 17 (2023)

von Eugen, K.; Endepols, H.; Drzezga, A.; Neumaier, B.; Güntürkün, O.; Backes, H.: Avian neurons consume three times less glucose than mammalian neurons. Current Biology 32 (19), S. 4306 - 4313.e4 (2022)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), S. 1466 - 1482.e7 (2021)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, S. 1662 - 1679 (2021)

Backes, H.: [11C]raclopride and extrastriatal binding to D2/3 receptors. NeuroImage 207, 116346 (2020)

Jais, A.; Paeger, L.; Sotelo-Hitschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J.M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, B. B.; Zeilhofer, H. U.; Fenselau, H.; Backes, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106 (6), S. 1009 - 1025.e10 (2020)

Nogova, L.; Mattonet, C.; Scheffler, M.; Taubert, M.; Gardizi, M.; Sos, M. L.; Michels, S.; Fischer, R. N.; Limburg, M.; Abdulla, D. S.Y. et al.; Persigehl, T.; Kobe, C.; Merkelbach-Bruse, S.; Franklin, J.; Backes, H.; Schnell, R.; Behringer, D.; Kaminsky, B.; Eichstaedt, M.; Stelzer, C.; Kinzig, M.; Sörgel, F.; Tian, Y.; Junge, L.; Suleiman, A. A.; Frechen, S.; Rokitta, D.; Ouyang, D.; Fuhr, U.; Buettner, R.; Wolf, J.: Sorafenib and everolimus in patients with advanced solid tumors and KRAS-mutated NSCLC: A phase I trial with early pharmacodynamic FDG-PET assessment. Cancer Medicine 9 (14), S. 4991 - 5007 (2020)

Timper, K.; Del Rio-Martin, A.; Cremer, A. L.; Bremser, S.; Alber, J.; Giavalisco, P.; Varela, L.; Heilinger, C.; Nolte, H.; Trifunovic, A. et al.; Horvath, T. L.; Kloppenburg, P.; Backes, H.; Brüning, J. C.: GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function. Cell Metabolism 31 (6), S. 1189 - 1205.e13 (2020)

Johann, K.; Cremer, A. L.; Fischer, A. W.; Heine, M.; Rial Pensado, E.; Resch, J.; Nock, S.; Virtue, S.; Harder, L.; Oelkrug, R. et al.; Astiz, M.; Brabant, G.; Warner, A.; Vidal-Puig, A.; Oster, H.; Boelen, A.; Lopez, M.; Heeren, J.; Dalley, J. W.; Backes, H.; Mittag, J.: Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption. Cell Reports 27 (11), S. 3385 - 3400, e3 (2019)

Lippert, R. N.; Cremer, A. L.; Thanarajah, S. E.; Korn, C.; Jahans-Price, T.; Burgeno, L. M.; Tittgemeyer, M.; Brüning, J. C.; Walton, M. E.; Backes, H.: Time-dependent assessment of stimulus-evoked regional dopamine release. Nature Communications 10 (1), 336 (2019)

Thanarajah, S. E.; Backes, H.; DiFeliceantonio, A.; Albus, K.; Cremer, A. L.; Hanssen, R.; Lippert, R. N.; Cornely, O. A.; Small, D. M.; Brüning, J. C. et al.; Tittgemeyer, M.: Food intake recruits orosensory and post-ingestive dopaminergic circuits to affect eating desire in humans. Cell Metabolism 29 (3), S. 695 - 706.e4 (2019)

Backes, H.; Walberer, M. I.; Ladwig, A.; Rueger, M. A.; Neumaier, B.; Endepols, H.; Höhn, M.; Fink, G. R.; Schroeter, M.; Graf, R.: Glucose consumption of inflammatory cells masks metabolic deficits in the brain. NeuroImage 128, S. 54 - 62 (2016)

Feuerstein, D.; Backes, H.; Gramer, M.; Takagaki, M.; Gabel, P.; Kumagai, T.; Graf, R.: Regulation of cerebral metabolism during cortical spreading depression. Journal of Cerebral Blood Flow and Metabolism 36 (11), S. 1965 - 1977 (2016)

Jais, A.; Solas, M.; Backes, H.; Chaurasia, B.; Kleinridders, A.; Theurich, S.; Mauer, J.; Steculorum, S. M.; Hampel, B.; Goldau, J. et al.; Alber, J.; Förster, C. Y.; Eming, S. A.; Schwaninger, M.; Ferrara, N.; Karsenty, G.; Brüning, J. C.: Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165 (4), S. 882 - 895 (2016)

Steculorum, S. M.; Ruud, J.; Karakasilioti, I.; Backes, H.; Engström Ruud, L.; Timper, K.; Heß, M. E.; Tsaousidou, E.; Mauer, J.; Vogt, M. C. et al.; Paeger, L.; Bremser, S.; Klein, A. C.; Morgan, D. A.; Frommolt, P.; Brinkkötter, P. T.; Hammerschmidt, P.; Benzing, T.; Rahmouni, K.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue. Cell 165 (1), S. 125 - 138 (2016)

Endepols, H.; Mertgens, H.; Backes, H.; Himmelreich, U.; Neumaier, B.; Graf, R.; Mies, G.: Longitudinal assessment of infarct progression, brain metabolism and behavior following anterior cerebral artery occlusion in rats. Journal of Neuroscience Methods 253, S. 279 - 291 (2015)

Walter, H. L.; Walberer, M.; Rüger, M. A.; Backes, H.; Wiedermann, D.; Höhn, M.; Neumaier, B.; Graf, R.; Fink, G. R.; Schroeter, M.: In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. Neuroscience 292 (April), S. 71 - 80 (2015)

Feuerstein, D.; Takagaki, M.; Gramer, M.; Manning, A.; Endepols, H.; Vollmar, S.; Yoshimine, T.; Strong, A. J.; Graf, R.; Backes, H.: Detecting tissue deterioration after brain injury: regional blood flow level versus capacity to raise blood flow. Journal of Cerebral Blood Flow and Metabolism 34 (7), S. 1117 - 1127 (2014)

Gramer, M.; Feuerstein, D.; Steimers, A.; Takagaki, M.; Kumagai, T.; Sué, M.; Vollmar, S.; Kohl-Bareis, M.; Backes, H.; Graf, R.: Device for simultaneous positron emission tomography, laser speckle imaging and RGB reflectometry: Validation and application to cortical spreading depression and brain ischemia in rats. NeuroImage 94, S. 250 - 262 (2014)