Publikationen von Frank Thomas Wunderlich

Ackermann, J.; Arndt, L.; Froeba, J.; Lindhorst, A.; Glass, M.; Kirstein, M.; Hobusch, C.; Wunderlich, F. T.; Braune, J.; Gericke, M.: IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages. Frontiers in Immunology 15, 1201439 (2024)

Baumgartner, F.; Bamopoulos, S. A.; Faletti, L.; Hsiao, H.-J.; Holz, M.; Gonzelez-Menendez, I.; Boldo, L.; Horne, A.; Gosavi, S.; Özerdem, C. et al.; Singh, N.; Liebig, S.; Ramamoorthy, S.; Lehmann, M.; Demel, U.; Kühl, A. A.; Wartewig, T.; Ruland, J.; Wunderlich, F. T.; Schick, M.; Walther, W.; Rose-John, S.; Haas, S.; Quintanilla-Martinez, L.; Feske, S.; Ehl, S.; Glauben, R.; Keller, U.: Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity. Science Signaling 17 (824), eadc9662 (2024)

Dodt, S.; Widdershooven, N. V.; Dreisow, M.-L.; Weiher, L.; Steuernagel, L.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 15 (1), 5439 (2024)

Engström Ruud, L.; Font-Gironès, F.; Zajdel, J.; Kern, L.; Teixidor-Deulofeu, J.; Manneras-Holm, L.; Carreras, A.; Becattini, B.; Björefeldt, A.; Hanse, E. et al.; Fenselau, H.; Solinas, G.; Brüning, J. C.; Wunderlich, F. T.; Bäckhed, F.; Ruud, J.: Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Reports 43 (4), 113960 (2024)

Henschke, S.; Nolte, H.; Magoley, J.; Kleele, T.; Brandt, C.; Hausen, A. C.; Wunderlich, C. M.; Bauder, C.; Aschauer, P.; Manley, S. et al.; Langer, T.; Wunderlich, F. T.; Brüning, J. C.: Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science 384 (6694), S. 438 - 446 (2024)

Khani, S.; Topel, H.; Kardinal, R.; Tavanez, A. R.; Josephrajan, A.; Larsen, B. D. M.; Gaudry, M. J.; Leyendecker, P.; Egedal, N. M.; Güller, A. S. et al.; Stanic, N.; Ruppert, P. M.M.; Gaziano, I.; Hansmeier, N. R.; Schmidt, E.; Klemm, P.; Vagliano, L.-M.; Stahl, R.; Duthie, F.; Krause, J.-H.; Bici, A.; Engelhard, C. A.; Gohlke, S.; Frommolt, P.; Gnad, T.; Rada-Iglesias, A.; Pradas-Juni, M.; Schulz, T. J.; Wunderlich, F. T.; Pfeifer, A.; Bartelt, A.; Jastroch, M.; Wachten, D.; Kornfeld, J.-W.: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nature Metabolism 6 (6), S. 1053 - 1075 (2024)

Knopp, T.; Jung, R.; Wild, J.; Bochenek, M.; Efentakis, P.; Lehmann, A.; Bieler, T.; Garlapati, V.; Richter, C.; Molitor, M. et al.; Perius, K.; Finger, S.; Lagrange, J.; Ghasemi, I.; Zifkos, K.; Kommoss, K. S.; Masri, J.; Reißig, S.; Randriamboavonjy, V.; Wunderlich, F. T.; Hövelmeyer, N.; Weber, A. N.R.; Mufazolov, I. A.; Bosmann, M.; Bechmann, I.; Fleming, I.; Oelze, M.; Daiber, A.; Münzel, T.; Schäfer, K.; Wenzel, P.; Waisman, A.; Karbach, S.: Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation. European Heart Journal Open 4 (4), oeae046 (2024)

Mulet, I.; Grueso-Cortina, C.; Cortés-Cano, M.; Gerovska, D.; Wu, G.; Iakab, S. A.; Jimenez-Blasko, D.; Curtabbi, A.; Hernansanz-Agustín, P.; Ketchum, H. et al.; Manjarrés-Raza, I.; Wunderlich, F. T.: TET3 regulates terminal cell differentiation at the metabolic level. Nature Communications 15 (1), 9749 (2024)

Peil, J.; Vossen, C.; Bock, F.; Clahsen, T.; Schiller, P.; Heindl, L. M.; Bosch, J. J.; Wunderlich, F. T.; Cursiefen, C.; Schlereth, S. L.: Combined Osteopontin Blockade and Type 2 Classical Dendritic Cell Vaccination as Effective Synergetic Therapy for Conjunctival Melanoma. The Journal of Immunology 212 (3), S. 487 - 499 (2024)

Vossen, C.; Schmidt, P.; Wunderlich, C. M.; Mittenbühler, M. J.; Tapken, C.; Wienand, P.; Mirabella, P. N.; Cabot, L.; Schumacher, A.-L.; Folz-Donahue, K. et al.; Kukat, C.; Voigt, I.; Brüning, J. C.; Fenselau, H.; Wunderlich, F. T.: An approach to intersectionally target mature enteroendocrine cells in the small intestine of mice. Cells 13 (1), 102 (2024)

Cox, E.-M.; El-Behi, M.; Ries, S.; Vogt, J. F.; Kohlhaas, V.; Michna, T.; Manfroi, B.; Al-Maarri, M.; Wanke, F.; Tirosh, B. et al.; Pondarre, C.; Lezeau, H.; Yogev, N.; Mittenzwei, R.; Descatoire, M.; Weller, S.; Weill, J.-C.; Reynaud, C.-A.; Boudinot, P.; Jouneau, L.; Tenzer, S.; Distler, U.; Rensing-Ehl, A.; König, C.; Staniek, J.; Rizzi, M.; Magérus, A.; Rieux-Laucat, F.; Wunderlich, F. T.; Hövelmeyer, N.; Fillatreau, S.: AKT activity orchestrates marginal zone B cell development in mice and humans. Cell Reports 42 (4), 112378 (2023)

Flümann, R.; Hansen, J.; Pelzer, B. W.; Nieper, P.; Lohmann, T.; Kisis, I.; Riet, T.; Kohlhas, V.; Nguyen, P.-H.; Peifer, M. et al.; Abedpour, N.; Bosco, G.; Thomas, R. K.; Kochanek, M.; Knüfer, J.; Jonigkeit, L.; Beleggia, F.; Holzem, A.; Büttner, R.; Lohneis, P.; Meinel, J.; Ortmann, M.; Persigehl, T.; Hallek, M.; Calado, D. P.; Chmielewski, M.; Klein, S.; Göthert, J. R.; Chapuy, B.; Zevnik, B.; Wunderlich, F. T.; von Tresckow, B.; Jachimowicz, R. D.; Melnick, A. M.; Reinhardt, H. C.; Knittel, G.: Distinct genetically determined origins of Myd88/BCL2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies. Blood Cancer Discovery 4 (1), S. 78 - 97 (2023)

Nagao, H.; Cai, W.; Brandao, B. B.; Wewer Albrechtsen, N. J.; Steger, M.; Gattu, A. K.; Pan, H.; Dreyfuss, J. M.; Wunderlich, F. T.; Mann, M. et al.; Kahn, R. C.: Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. Journal of Clinical Investigation (New York, NY) 133 (4), e161472 (2023)

Nikopoulou, C.; Kleinenkuhnen, N.; Parekh, S.; Sandoval, T.; Ziegenhain, C.; Schneider, F.; Giavalisco, P.; Donahue, K.-F.; Vesting, A. J.; Kirchner, M. et al.; Bozukova, M.; Vossen, C.; Altmüller, J.; Wunderlich, F. T.; Sandberg, R.; Kondylis, V.; Tresch, A.; Tessarz, P.: Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver. Nature aging 3 (11), S. 1430 - 1445 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Selle, J.; Dinger, K.; Jentgen, V.; Zanetti, D.; Will, J.; Georgomanolis, T.; Vohlen, C.; Wilke, R.; Kojonazarov, B.; Klymenko, O. et al.; Mohr, J.; von Koningsbruggen-Rietschel, S.; Rhodes, C. J.; Ulrich, A.; Hirani, D.; Nestler, T.; Odenthal, M.; Mahabir, E.; Nayakanti, S.; Dabral, S.; Wunderlich, F. T.; Priest, J.; Seeger, W.; Dötsch, J.; Pullamsetti, S. S.; Alejandre Alcazar, M. A.: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nature Communications 13 (1), 4352 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Werr, L.; Plenker, D.; Dammert, M. A.; Lorenz, C.; Bragelmann, J.; Tumbrink, H. L.; Klein, S.; Schmitt, A.; Buttner, R.; Persigehl, T. et al.; Shokat, K. M.; Wunderlich, F. T.; Schram, A. M.; Peifer, M.; Sos, M. L.; Reinhardt, H. C.; Thomas, R. K.: CD74-NRG1 fusions are oncogenic in vivo and induce therapeutically tractable ERBB2:ERBB3 heterodimerization. Molecular Cancer Therapeutics 21 (5), S. 821 - 830 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), S. 913 - 929+ (2021)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), S. 1466 - 1482.e7 (2021)