Publications of Alexander Jais

Jais, A.; Brüning, J. C.: Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocrine Reviews 43 (2), pp. 314 - 328 (2022)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, pp. 1662 - 1679 (2021)

Willenborg, S.; Sanin, D. E.; Jais, A.; Ding, X.; Ulas, T.; Nuchel, J.; Popovic, M.; MacVicar, T.; Langer, T.; Schultze, J. L. et al.; Gerbaulet, A.; Roers, A.; Pearce, E. J.; Brüning, J. C.; Trifunovic, A.; Eming, S. A.: Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33 (12), pp. 2398 - 2414.e9 (2021)

Ding, X.; Willenborg, S.; Bloch, W.; Wickström, S. A.; Wagle, P.; Brodesser, S.; Roers, A.; Jais, A.; Brüning, J. C.; Hall, M. N. et al.; Rüegg, M. A.; Eming, S. A.: Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology 145 (1), pp. 283 - 300.e8 (2020)

Hammerschmidt, P.; Ostkotte, D.; Nolte, H.; Gerl, M. J.; Jais, A.; Brunner, H. L.; Sprenger, H.-G.; Awazawa, M.; Nicholls, H. T.; Turpin-Nolan, S. M. et al.; Langer, T.; Krüger, M.; Brügger, B.; Brüning, J. C.: CerS6-derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity. Cell 177 (6), pp. 1536 - 1552.e23 (2019)

Rao, S.; Mondragón, L.; Pranjic, B.; Hanada, T.; Stoll, G.; Köcher, T.; Zhang, P.; Jais, A.; Lercher, A.; Bergthaler, A. et al.; Schramek, D.; Haigh, K.; Sica, V.; Leduc, M.; Modjtahedi, N.; Pai, T.-P.; Onji, M.; Uribesalgo, I.; Hanada, R.; Kozieradzki, I.; Koglgruber, R.; Cronin, S. J.; She, Z.; Quehenberger, F.; Popper, H.; Kenner, L.; Haigh, J. J.; Kepp, O.; Rak, M.; Cai, K.; Kroemer, G.; Penninger, J.: AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Research 29 (7), pp. 579 - 591 (2019)

Turpin-Nolan, S. M.; Hammerschmidt, P.; Chen, W.; Jais, A.; Timper, K.; Awazawa, M.; Brodesser, S.; Brüning, J. C.: CerS1-derived C18:0 ceramide in skeletal muscle promotes obesity-induced insulin resistance. Cell Reports 26 (1), pp. 1 - 10.e7 (2019)

Cronin, S. J.F.; Seehus, C.; Weidinger, A.; Talbot, S.; Reissig, S.; Seifert, M.; Pierson, Y.; McNeill, E.; Longhi, M. S.; Lenfers Turnes, B. et al.; Kreslavsky, T.; Kogler, M.; Hoffmann, D.; Ticevic, M.; Da Luz Scheffer, D.; Tortola, L.; Cikes, D.; Jais, A.; Rangachari, M.; Rao, S.; Paolino, M.; Novatchkova, M.; Aichinger, M.; Barrett, L.; Latremoliere, A.; Wirnsberger, G.; Lametschwandtner, G.; Busslinger, M.; Zicha, S.; Latini, A.; Robson, S. C.; Waisman, A.; Andrews, N.; Costigan, M.; Channon, K. M.; Weiss, G.; Kozlov, A. V.; Tebbe, M.; Johnsson, K.; Woolf, C. J.; Penninger, J.: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563 (7732), pp. 564 - 568 (2018)

Schüler, R.; Seebeck, N.; Osterhoff, M. A.; Witte, V.; Flöel, A.; Busjahn, A.; Jais, A.; Brüning, J. C.; Frahnow, T.; Kabisch, S. et al.; Pivovarova, O.; Hornemann, S.; Kruse, M.; Pfeiffer, A. F.H.: VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans. Molecular Metabolism 11 (May), pp. 129 - 136 (2018)

Timper, K.; Paeger, L.; Sanchez-Lasheras, C.; Varela, L.; Jais, A.; Nolte, H.; Vogt, M. C.; Hausen, A. C.; Heilinger, C.; Evers, N. et al.; Pospisilik, J. A.; Penninger, J. M.; Taylor, E. B.; Horvath, T. L.; Kloppenburg, P.; Brüning, J. C.: Mild impairment of mitochondrial OXPHOS promotes fatty acid utilization in POMC neurons and improves glucose homeostasis in obesity. Cell Reports 25 (2), pp. 383 - 397 (2018)

Jais, A.; Brüning, J. C.: Hypothalamic inflammation in obesity and metabolic disease. The Journal of Clinical Investigation 127 (1), pp. 24 - 32 (2017)

Rao, S.; Sigl, V.; Wimmer, R. A.; Novatchkova, M.; Jais, A.; Wagner, G.; Handschuh, S.; Uribesalgo, I.; Hagelkruys, A.; Kozieradzki, I. et al.; Tortola, L.; Nitsch, R.; Cronin, S. J.; Orthofer, M.; Branstetter, D.; Canon, J.; Rossi, J.; D'Arcangelo, M.; Botling, J.; Micke, P.; La Fleur, L.; Edlund, K.; Bergqvist, M.; Ekman, S.; Lendl, T.; Popper, H.; Takayanagi, H.; Kenner, L.; Hirsch, F. R.; Dougall, W.; Penninger, J.: RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes and Development 31 (20), pp. 2099 - 2112 (2017)