Publications of Jens Claus Brüning

Mauer, J.; Chaurasia, B.; Goldau, J.; Vogt, M. C.; Ruud, J.; Nguyen, K. D.; Theurich, S.; Hausen, A. C.; Schmitz, J.; Brönneke, H. S. et al.; Estevez, E.; Allen, T. L.; Mesaros, A.; Partridge, L.; Febbraio, M. A.; Chawla, A.; Wunderlich, F. T.; Brüning, J. C.: Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nature Immunology 15 (5), pp. 423 - 430 (2014)

Nish, S. A.; Schenten, D.; Wunderlich, F. T.; Pope, S. D.; Gao, Y.; Hoshi, N.; Yu, S.; Yan, X.; Lee, H. K.; Pasman, L. et al.; Brodsky, I.; Yordy, B.; Zhao, H.; Brüning, J. C.; Medzhitov, R.: T cell-intrinsic role of IL-6 signaling in primary and memory responses. eLife (3), 01949 (2014)

Patti, G. J.; Tautenhahn, R.; Johannsen, D.; Kalisiak, E.; Ravussin, E.; Brüning, J. C.; Dillin, A.; Siuzdak, G.: Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension. Metabolomics 10 (4), pp. 737 - 743 (2014)

Schenten, D.; Nish, S. A.; Yu, S.; Yan, X.; Lee, H. K.; Brodsky, I.; Pasman, L.; Yordy, B.; Wunderlich, F. T.; Brüning, J. C. et al.; Zhao, H.; Medzhitov, R.: Signaling through the adaptor molecule MyD88 in CD4(+) T cells is required to overcome suppression by regulatory T cells. Immunity 40 (1), pp. 78 - 90 (2014)

Steculorum, S. M.; Brüning, J. C.: Die another day: A painless path to longevity. Cell 157 (5), pp. 1004 - 1006 (2014)

Steculorum, S. M.; Solas, M.; Brüning, J. C.: The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimer's and Dementia 10 (1, Suppl.), pp. S3 - S11 (2014)

Tsaousidou, E.; Paeger, L.; Belgardt, B. F.; Pal, M.; Wunderlich, C. M.; Brönneke, H. S.; Collienne, U.; Hampel, B.; Wunderlich, F. T.; Schmidt-Supprian, M. et al.; Kloppenburg, P.; Brüning, J. C.: Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Cell Reports 9 (4), pp. 1495 - 1506 (2014)

Turpin, S. M.; Nicholls, H. T.; Willmes, D. M.; Mourier, A.; Brodesser, S.; Wunderlich, C. M.; Mauer, J.; Xu, E.; Hammerschmidt, P.; Brönneke, H. S. et al.; Trifunovic, A.; LoSasso, G.; Wunderlich, F. T.; Kornfeld, J.-W.; Blüher, M.; Krönke, M.; Brüning, J. C.: Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metabolism 20 (4), pp. 678 - 686 (2014)

Vogt, M. C.; Paeger, L.; Hess, S.; Steculorum, S. M.; Awazawa, M.; Hampel, B.; Neupert, S.; Nicholls, H. T.; Mauer, J.; Hausen, A. C. et al.; Predel, R.; Kloppenburg, P.; Horvath, T. L.; Brüning, J. C.: Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell 156 (3), pp. 495 - 509 (2014)

Gahete, M. D.; Cordoba-Chacon, J.; Lin, Q.; Brüning, J. C.; Kahn, C. R.; Castano, J. P.; Christian, H.; Luque, R. M.; Kineman, R. D.: Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology 154 (7), pp. 2410 - 2420 (2013)

Gruber, S.; Straub, B.; Ackermann, P. J.; Wunderlich, C. M.; Mauer, J.; Seeger, J. M.; Büning, H.; Heukamp, L.; Kashkar, H.; Schirmacher, P. et al.; Brüning, J. C.; Wunderlich, F. T.: Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling. Cell Reports 4 (4), pp. 669 - 680 (2013)

Günschmann, C.; Stachelscheid, H.; Akyüz, M. D.; Schmitz, A.; Missero, C.; Brüning, J. C.; Niessen, C. M.: Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Developmental Cell 26 (2), pp. 176 - 187 (2013)

Hess, M. E.; Hess, S.; Meyer, K. D.; Verhagen, L. A. W.; Koch, L.; Brönneke, H. S.; Dietrich, M. O.; Jordan, S. D.; Saletore, Y.; Elemento, O. et al.; Belgardt, B. F.; Franz, T.; Horvath, T. L.; Rüther, U.; Jaffrey, S. R.; Kloppenburg, P.; Brüning, J. C.: The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience 16 (8), pp. 1042 - 1048 (2013)

Karra, E.; O'Daly, O. G.; Choudhury, A. I.; Yousseif, A.; Millership, S.; Neary, M. T.; Scott, W. R.; Chandarana, K.; Manning, S.; Hess, M. E. et al.; Iwakura, H.; Akamizu, T.; Millet, Q.; Gelegen, C.; Drew, M. E.; Rahman, S.; Emmanuel, J. J.; Williams, S. C. R.; Rüther, U. U.; Brüning, J. C.; Withers, D. J.; Zelaya, F. O.; Batterham, R. L.: A link between FTO, ghrelin, and impaired brain food-cue responsivity. Journal of Clinical Investigation 123 (8), pp. 3539 - 3551 (2013)

Kornfeld, J.-W.; Baitzel, C.; Könner, C. A.; Nicholls, H. T.; Vogt, M. C.; Hermanns, K.; Scheja, L.; Haumaitre, C.; Wolf, A. M.; Knippschild, U. et al.; Seibler, J.; Cereghini, S.; Heeren, J.; Stoffel, M.; Brüning, J. C.: Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 494 (7435), pp. 111 - 115 (2013)

Newton, A. J.; Hess, S.; Paeger, L.; Vogt, M. C.; Lascano, J. F.; Nillni, E. A.; Brüning, J. C.; Kloppenburg, P.; Xu, A. W.: AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology 154 (1), pp. 172 - 183 (2013)

Steculorum, S. M.; Vogt, M. C.; Brüning, J. C.: Perinatal programming of metabolic diseases. Role of insulin in the development of hypothalamic neurocircuits. Endocrinology and Metabolism Clinics of North America 42 (1), pp. 149 - 164 (2013)

Stöhr, O.; Schilbach, K.; Moll, L.; Hettich, M. M.; Freude, S.; Wunderlich, F. T.; Ernst, M.; Zemva, J.; Brüning, J. C.; Krone, W. et al.; Udelhoven, M.; Schubert, M.: Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. AGE 35 (1), pp. 83 - 101 (2013)

Tovar, S.; Paeger, L.; Hess, S.; Morgan, D. A.; Hausen, A. C.; Brönneke, H. S.; Hampel, B.; Ackermann, P. J.; Evers, N.; Büning, H. et al.; Wunderlich, F. T.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: KATP-Channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis. Cell Metabolism 18 (3), pp. 445 - 455 (2013)

Vogt, M. C.; Brüning, J. C.: CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age. Trends in Endocrinology and Metabolism 24 (2), pp. 76 - 84 (2013)