Publications of Jens Claus Brüning

Amatruda, M.; Marechal, D.; Gacias, M.; Wentling, M.; Turpin-Nolan, S. M.; Morstein, J.; Moniruzzaman, M.; Brüning, J. C.; Haughey, N. J.; Trauner, D. H. et al.; Casaccia, P.: Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia, pp. 1 - 20 (2024)

Ardanaz, C. G.; de la Cruz, A.; Minhas, A.; Hernandez-Martin, N.; Pozo, M. A.; Valdecantos, M. P.; Valverde, A. M.; Villa-Valverde, P.; Elizalde-Horcada, M.; Puerta, E. et al.; Ramirez, M. J.; Ortega, J. E.; Urbiola, A.; Ederra, C.; Ariz, M.; Ortiz-De-Solorzano, C.; Fernandez-Irigoyen, J.; Santamaria, E.; Karsenty, G.; Brüning, J. C.; Solas, M.: Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances 10 (42), eadp1115 (2024)

de Solis, A. J.; Del Rio-Martin, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A. L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 6 (3), pp. 473 - 493 (2024)

Dodt, S.; Widdershooven, N. V.; Dreisow, M.-L.; Weiher, L.; Steuernagel, L.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 15 (1), 5439 (2024)

Engström Ruud, L.; Font-Gironès, F.; Zajdel, J.; Kern, L.; Teixidor-Deulofeu, J.; Manneras-Holm, L.; Carreras, A.; Becattini, B.; Björefeldt, A.; Hanse, E. et al.; Fenselau, H.; Solinas, G.; Brüning, J. C.; Wunderlich, F. T.; Bäckhed, F.; Ruud, J.: Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Reports 43 (4), 113960 (2024)

Henschke, S.; Nolte, H.; Magoley, J.; Kleele, T.; Brandt, C.; Hausen, A. C.; Wunderlich, C. M.; Bauder, C.; Aschauer, P.; Manley, S. et al.; Langer, T.; Wunderlich, F. T.; Brüning, J. C.: Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science 384 (6694), pp. 438 - 446 (2024)

Leon, S.; Simon, V.; Lee, T. H.; Steuernagel, L.; Clark, S.; Biglari, N.; Lesté-Lassere, T.; Dupuy, N.; Cannich, A.; Bellocchio, L. et al.; Zizzari, P.; Allard, C.; Gonzales, D.; Le Feuvre, Y.; Lhuillier, E.; Brochard, A.; Nicolas, J. C.; Teillon, J.; Nikolski, M.; Marsicano, G.; Fioramonti, X.; Brüning, J. C.; Cota, D.; Quarta, C.: Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity. Nature Communications 15, 3443 (2024)

Sotelo-Hitschfeld, T.; Minère, M.; Klemm, P.; Borgmann, D.; Wnuk-Lipinski, D.; Jais, A.; Jia, X.; Corneliussen, S.; Kloppenburg, P.; Fenselau, H. et al.; Brüning, J. C.: GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Reports 43 (6), 114343 (2024)

Springer, C.; Binsch, C.; Weide, D.; Toska, L.; Cremer, A. L.; Backes, H.; Scheel, A. K.; Espelage, L.; Kotzka, J.; Sill , S. et al.; Kurowski, A.; Kim, D.; Karpinski, S.; Schnurr, T. M.; Hansen, T.; Hartwig, S.; Lehr, S.; Cames, S.; Brüning, J. C.; Lienhard, M.; Herwig, R.; Börno, S.; Timmermann, B.; Al-Hasani, H.; Chadt, A.: Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance. Diabetes 73 (7), pp. 1058 - 1071 (2024)

Vossen, C.; Schmidt, P.; Wunderlich, C. M.; Mittenbühler, M. J.; Tapken, C.; Wienand, P.; Mirabella, P. N.; Cabot, L.; Schumacher, A.-L.; Folz-Donahue, K. et al.; Kukat, C.; Voigt, I.; Brüning, J. C.; Fenselau, H.; Wunderlich, F. T.: An approach to intersectionally target mature enteroendocrine cells in the small intestine of mice. Cells 13 (1), 102 (2024)

Zhou, X.; Stine, C.; Prada, P. O. d.; Fusca, D.; Assoumou, K.; Dernic, J.; Bhat, M. A.; Achanta, A. S.; Johnson, J. C.; Pasqualini, A. L. et al.; Jadhav, S.; Bauder, C. A.; Steuernagel, L.; Ravotto, L.; Benke, D.; Weber, B.; Suko, A.; Palmiter, R. D.; Stoeber, M.; Kloppenburg, P.; Brüning, J. C.; Bruchas, M. R.; Patriarchi, T.: Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release. Nature Communications 15 (1), 5353 (2024)

Brüning, J. C.; Fenselau, H.: Integrative neurocircuits that control metabolism and food intake. Science 381 (6665), eabl7398 (2023)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35 (5), pp. 786 - 806.e13 (2023)

Edwin Thanarajah, S.; DiFeliceantonio, A.; Albus, K.; Kuzmanovic, B.; Rigoux, L.; Iglesias, S.; Hanßen, R.; Schlamann, M.; Cornely, O. A.; Brüning, J. C. et al.; Tittgemeyer, M.; Small, D. M.: Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. Cell Metabolism 35 (4), pp. 571 - 584.e6 (2023)

Griess, K.; Rieck, M.; Müller, N.; Karsai, G.; Hartwig, S.; Pelligra, A.; Hardt, R.; Schlegel, C.; Kuboth, J.; Uhlemeyer, C. et al.; Trenkamp, S.; Jeruschke, K.; Weiss, J.; Peifer-Weiss, L.; Xu, W.; Cames, S.; Yi, X.; Cnop, M.; Beller, M.; Stark, H.; Kondadi, A. K.; Reichert, A. S.; Markgraf, D.; Wammers, M.; Häussinger, D.; Kuss, O.; Lehr, S.; Eizirik, D.; Lickert, H.; Lammert, E.; Roden, M.; Winter, D.; Al-Hasani, H.; Höglinger, D.; Hornemann, T.; Brüning, J. C.; Belgardt, B.-F.: Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature Cell Biology 25 (1), pp. 20 - 29 (2023)

Hammerschmidt, P.; Steculorum, S. M.; Bandet, C. L.; Del Rio-Martin, A.; Steuernagel, L.; Kohlhaas, V.; Feldmann, M.; Varela, L.; Majcher, A.; Quatorze Correia, M. et al.; Klar, R. F.U.; Bauder, C. A.; Kaya, E.; Porniece, M.; Biglari, N.; Sieben, A.; Horvath, T. L.; Hornemann, T.; Brodesser, S.; Brüning, J. C.: CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications 14 (1), 7824 (2023)

Hanssen, R.; Rigoux, L.; Albus, K.; Kretschmer, A. C.; Thanarajah, S. E.; Chen, W. Y.; Hinze, Y.; Giavalisco, P.; Steculorum, S. M.; Cornely, O. A. et al.; Brüning, J. C.; Tittgemeyer, M.: Circulating uridine dynamically and adaptively regulates food intake in humans. Cell Reports Medicine 4 (1), 100897 (2023)

Hanßen, R.; Rigoux, L.; Kuzmanovic, B.; Iglesias, S.; Kretschmer, A. C.; Schlamann, M.; Albus, K.; Thanarajah, S. E.; Sitnikow, T.; Melzer, C. et al.; Cornely, O. A.; Brüning, J. C.; Tittgemeyer, M.: Liraglutide restores impaired associative learning in individuals with obesity. Nature Metabolism 5 (8), pp. 1352 - 1363 (2023)

Hune, T. L.K.; Mamone, S.; Schmidt, A. B.; Mahu, I.; D'Apolito, N.; Wiedermann, D.; Brüning, J. C.; Glöggler, S.: Hyperpolarized multi-organ spectroscopy of liver and brain using 1-C-13-pyruvate enhanced via parahydrogen. Applied Magnetic Resonance 54 (11-12), pp. 1283 - 1295 (2023)

Parra-Vargas, M.; Bouret, S. G.; Brüning, J. C.; de Moura, E. G.; Garland, T.; Lisboa, P. C.; Ozanne, S. E.; Patti, M.-E.; Plagemann, A.; Speakman, J. R. et al.; Tena-Sempere, M.; Vergely, C.; Zeltser, L. M.; Jiménez-Chillarón, J. C.: The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Molecular Metabolism 71, 101707 (2023)