Publications of Jens Claus Brüning

Teo, J. D.; Marian, O. C.; Spiteri, A. G.; Nicholson, M.; Song, H.; Khor, J. X. Y.; McEwen, H. P.; Ge, A.; Sen, M. K.; Piccio, L. et al.; Fletcher, J. L.; King, N. J. C.; Murray, S. S.; Brüning, J. C.; Don, A. S.: Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. Glia 71 (4), pp. 1120 - 1141 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Hammerschmidt, P.; Brüning, J. C.: Contribution of specific ceramides to obesity-associated metabolic diseases. Cellular and Molecular Life Sciences 79 (8), 395 (2022)

Hanssen, R.; Thanarajah, S. E.; Tittgemeyer, M.; Brüning, J. C.: Obesity - A Matter of Motivation? Experimental and Clinical Endocrinology & Diabetes 130 (5), pp. 290 - 295 (2022)

Hoyer-Allo, K. J. R.; Späth, M. R.; Brodesser, S.; Zhu, Y.; Binz-Lotter, J.; Höhne, M.; Brönneke, H. S.; Bohl, K.; Johnsen, M.; Kubacki, T. et al.; Kiefer, K.; Seufert, L.; Koehler, F. C.; Grundmann, F.; Hackl, M. J.; Schermer, B.; Brüning, J. C.; Benzing, T.; Burst, V.; Müller, R. U.: Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury. Kidney International 102 (3), pp. 560 - 576 (2022)

Jais, A.; Brüning, J. C.: Arcuate nucleus-dependent regulation of metabolism - pathways to obesity and diabetes mellitus. Endocrine Reviews 43 (2), pp. 314 - 328 (2022)

Lippert, R. N.; Brüning, J. C.: Maternal metabolic programming of the developing central nervous system – unified pathways to metabolic and psychiatric disorders. Biological Psychiatry 91 (10), pp. 898 - 906 (2022)

Matsushita, M.; Awazawa, M.; Kobayashi, N.; Ikushima, Y. M.; Soeda, K.; Tamura-Nakano, M.; Muratani, M.; Kobayashi, K.; Bluher, M.; Brüning, J. C. et al.; Ueki, K.: An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell Chemical Biology 29 (4), pp. 680 - 689.e6 (2022)

Meron, E.; Thaysen, M.; Angeli, S.; Antebi, A.; Barzilai, N.; Baur, J. A.; Bekker-Jensen, S.; Birkisdottir, M.; Bischof, E.; Brüning, J. C. et al.; Brunet, A.; Buchwalter, A.; Cabreiro, F.; Cai, S.; Chen, B. H.; Ermolaeva, M.; Ewald, C. Y.; Ferrucci, L.; Florian, M. C.; Fortney, K.; Freund, A.; Georgievskaya, A.; Gladyshev, V. N.; Glass, D.; Golato, T.; Gorbunova, V.; Hoejimakers, J.; Houtkooper, R. H.; Jager, S.; Jaksch, F.; Janssens, G.; Jensen, M. B.; Kaeberlein, M.; Karsenty, G.; de Keizer, P.; Kennedy, B.; Kirkland, J. L.; Kjaer, M.; Kroemer, G.; Lee, K.-F.; Lemaitre, J.-M.; Liaskos, D.; Longo, V. D.; Lu, Y.-X.; MacArthur, M. R.; Maier, A. B.; Manakanatas, C.; Mitchell, S. J.; Moskalev, A.; Niedernhofer, L.; Ozerov, I.; Partridge, L.; Passegue, E.; Petr, M. A.; Peyer, J.; Radenkovic, D.; Rando, T. A.; Rattan, S.; Riedel, C. G.; Rudolph, L.; Ai, R.; Serrano, M.; Schumacher, B.; Sinclair, D. A.; Smith, R.; Suh, Y.; Taub, P.; Trapp, A.; Trendelenburg, A.-U.; Valenzano, D. R.; Verburgh, K.; Verdin, E.; Vijg, J.; Westendorp, R. G.J.; Zonari, A.; Bakula, D.; Zhavoronkov, A.; Scheibye-Knudsen, M.: Meeting Report: Aging Research and Drug Discovery. Aging 14 (2), pp. 530 - 543 (2022)

Ramírez, S.; Haddad-Tóvolli, R.; Radosevic, M.; Toledo, M.; Pané, A.; Alcolea, D.; Ribas, V.; Milà-Guasch, M.; Pozo, M.; Obri, A. et al.; Eyre, E.; Gómez-Valadés, A. G.; Chivite, I.; Van Eeckhout, T.; Zalachoras, I.; Altirriba, J.; Bauder, C.; Imbernón, M.; Garrabou, G.; Garcia-Ruiz, C.; Nogueiras, R.; Soto, D.; Gasull, X.; Sandi, C.; Brüning, J. C.; Fortea, J.; Jiménez, A.; Fernández-Checa, J. C.; Claret, M.: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metabolism 34 (2), pp. 269 - 284.e9 (2022)

Steuernagel, L.; Lam, B. Y. H.; Klemm, P.; Dowsett, G. K. C.; Bauder, C. A.; Tadross, J. A.; Sotelo-Hitschfeld, T.; Del Rio-Martin, A.; Chen, W.; De Solis, A. J. et al.; Fenselau, H.; Davidsen, P.; Cimino, I.; Kohnke, S. N.; Rimmington, D.; Coll, A. P.; Beyer, A.; Yeo, G. S. H.; Brüning, J. C.: HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nature Metabolism 4 (10), pp. 1402 - 1419 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), pp. 913 - 929+ (2021)

Aravamudhan, S.; Türk, C.; Bock, T.; Keufgens, L.; Nolte, H.; Lang, F.; Krishnan, R. K.; König, T.; Hammerschmidt, P.; Schindler, N. et al.; Brodesser, S.; Rozsivalova, D. H.; Rugarli, E. I.; Trifunovic, A.; Brüning, J. C.; Langer, T.; Braun, T.; Krueger, M.: Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. Journal of Molecular and Cellular Cardiology (London) 154, pp. 41 - 49 (2021)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), pp. 1466 - 1482.e7 (2021)

Brüning, J. C.; García Cáceres, C.; Heni , M.; Preißl, H.: Insulinwirkung und -resistenz im Gehirn. Diabetes Aktuell 19 (2), pp. 72 - 75 (2021)

Dodd, G. T.; Kim, S. J.; Mequinion, M.; Xirouchaki, C. E.; Brüning, J. C.; Andrews, Z. B.; Tiganis, T.: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Science Advances 7 (9), eabf4100 (2021)

Hanssen, R.; Kretschmer, A. C.; Rigoux, L.; Albus, K.; Thanarajah, S. E.; Sitnikow, T.; Melzer, C.; Cornely, O. A.; Brüning, J. C.; Tittgemeyer, M.: GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Molecular Metabolism 45, 101163 (2021)

Hoyer-Allo, K. J. R.; Späth, M. R.; Hanssen, R.; Johnsen, M.; Brodesser, S.; Kaufmann, K.; Kiefer, K.; Koehler, F. C.; Göbel, H.; Kubacki, T. et al.; Grundmann, F.; Schermer, B.; Brüning, J. C.; Benzing, T.; Burst, V.; Müller, R.-U.: Modulation of endocannabinoids by caloric restriction is conserved in mice but is not required for protection from acute kidney injury. International Journal of Molecular Sciences 22 (11), 5485 (2021)

Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hövelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Herling, C.; Hartmann, E. M.; Rosenwald, A.; Klapper, W.; Büttner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood 137 (5), pp. 646 - 660 (2021)