Publications of Jens Claus Brüning

Meron, E.; Thaysen, M.; Angeli, S.; Antebi, A.; Barzilai, N.; Baur, J. A.; Bekker-Jensen, S.; Birkisdottir, M.; Bischof, E.; Brüning, J. C. et al.; Brunet, A.; Buchwalter, A.; Cabreiro, F.; Cai, S.; Chen, B. H.; Ermolaeva, M.; Ewald, C. Y.; Ferrucci, L.; Florian, M. C.; Fortney, K.; Freund, A.; Georgievskaya, A.; Gladyshev, V. N.; Glass, D.; Golato, T.; Gorbunova, V.; Hoejimakers, J.; Houtkooper, R. H.; Jager, S.; Jaksch, F.; Janssens, G.; Jensen, M. B.; Kaeberlein, M.; Karsenty, G.; de Keizer, P.; Kennedy, B.; Kirkland, J. L.; Kjaer, M.; Kroemer, G.; Lee, K.-F.; Lemaitre, J.-M.; Liaskos, D.; Longo, V. D.; Lu, Y.-X.; MacArthur, M. R.; Maier, A. B.; Manakanatas, C.; Mitchell, S. J.; Moskalev, A.; Niedernhofer, L.; Ozerov, I.; Partridge, L.; Passegue, E.; Petr, M. A.; Peyer, J.; Radenkovic, D.; Rando, T. A.; Rattan, S.; Riedel, C. G.; Rudolph, L.; Ai, R.; Serrano, M.; Schumacher, B.; Sinclair, D. A.; Smith, R.; Suh, Y.; Taub, P.; Trapp, A.; Trendelenburg, A.-U.; Valenzano, D. R.; Verburgh, K.; Verdin, E.; Vijg, J.; Westendorp, R. G.J.; Zonari, A.; Bakula, D.; Zhavoronkov, A.; Scheibye-Knudsen, M.: Meeting Report: Aging Research and Drug Discovery. Aging 14 (2), pp. 530 - 543 (2022)

Ramírez, S.; Haddad-Tóvolli, R.; Radosevic, M.; Toledo, M.; Pané, A.; Alcolea, D.; Ribas, V.; Milà-Guasch, M.; Pozo, M.; Obri, A. et al.; Eyre, E.; Gómez-Valadés, A. G.; Chivite, I.; Van Eeckhout, T.; Zalachoras, I.; Altirriba, J.; Bauder, C.; Imbernón, M.; Garrabou, G.; Garcia-Ruiz, C.; Nogueiras, R.; Soto, D.; Gasull, X.; Sandi, C.; Brüning, J. C.; Fortea, J.; Jiménez, A.; Fernández-Checa, J. C.; Claret, M.: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metabolism 34 (2), pp. 269 - 284.e9 (2022)

Steuernagel, L.; Lam, B. Y. H.; Klemm, P.; Dowsett, G. K. C.; Bauder, C. A.; Tadross, J. A.; Sotelo-Hitschfeld, T.; Del Rio-Martin, A.; Chen, W.; De Solis, A. J. et al.; Fenselau, H.; Davidsen, P.; Cimino, I.; Kohnke, S. N.; Rimmington, D.; Coll, A. P.; Beyer, A.; Yeo, G. S. H.; Brüning, J. C.: HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nature Metabolism 4 (10), pp. 1402 - 1419 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), pp. 913 - 929+ (2021)

Aravamudhan, S.; Türk, C.; Bock, T.; Keufgens, L.; Nolte, H.; Lang, F.; Krishnan, R. K.; König, T.; Hammerschmidt, P.; Schindler, N. et al.; Brodesser, S.; Rozsivalova, D. H.; Rugarli, E. I.; Trifunovic, A.; Brüning, J. C.; Langer, T.; Braun, T.; Krueger, M.: Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. Journal of Molecular and Cellular Cardiology (London) 154, pp. 41 - 49 (2021)

Borgmann, D.; Ciglieri, E.; Biglari, N.; Brandt, C.; Cremer, A. L.; Backes, H.; Tittgemeyer, M.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism 33 (7), pp. 1466 - 1482.e7 (2021)

Brüning, J. C.; García Cáceres, C.; Heni , M.; Preißl, H.: Insulinwirkung und -resistenz im Gehirn. Diabetes Aktuell 19 (2), pp. 72 - 75 (2021)

Dodd, G. T.; Kim, S. J.; Mequinion, M.; Xirouchaki, C. E.; Brüning, J. C.; Andrews, Z. B.; Tiganis, T.: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Science Advances 7 (9), eabf4100 (2021)

Hanssen, R.; Kretschmer, A. C.; Rigoux, L.; Albus, K.; Thanarajah, S. E.; Sitnikow, T.; Melzer, C.; Cornely, O. A.; Brüning, J. C.; Tittgemeyer, M.: GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Molecular Metabolism 45, 101163 (2021)

Hoyer-Allo, K. J. R.; Späth, M. R.; Hanssen, R.; Johnsen, M.; Brodesser, S.; Kaufmann, K.; Kiefer, K.; Koehler, F. C.; Göbel, H.; Kubacki, T. et al.; Grundmann, F.; Schermer, B.; Brüning, J. C.; Benzing, T.; Burst, V.; Müller, R.-U.: Modulation of endocannabinoids by caloric restriction is conserved in mice but is not required for protection from acute kidney injury. International Journal of Molecular Sciences 22 (11), 5485 (2021)

Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hövelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Herling, C.; Hartmann, E. M.; Rosenwald, A.; Klapper, W.; Büttner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood 137 (5), pp. 646 - 660 (2021)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, pp. 1662 - 1679 (2021)

Quarta, C.; Claret, M.; Zeltser, L. M.; Williams, K. W.; Yeo, G. S.H.; Tschöp, M. H.; Diano, S.; Brüning, J. C.; Cota, D.: POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nature Metabolism 3 (3), pp. 299 - 308 (2021)

Welcker, D.; Stein, C.; Feitosa, N. M.; Armistead, J.; Zhang, J.-L.; Lütke, S.; Kleinridders, A.; Brüning, J. C.; Eming, S. A.; Sengle, G. et al.; Niehoff, A.; Bloch, W.; Hammerschmidt, M.: Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions. Scientific Reports 11, 17926 (2021)

Willenborg, S.; Sanin, D. E.; Jais, A.; Ding, X.; Ulas, T.; Nuchel, J.; Popovic, M.; MacVicar, T.; Langer, T.; Schultze, J. L. et al.; Gerbaulet, A.; Roers, A.; Pearce, E. J.; Brüning, J. C.; Trifunovic, A.; Eming, S. A.: Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33 (12), pp. 2398 - 2414.e9 (2021)

Xiao, X.; Yeghiazaryan, G.; Hess, S.; Klemm, P.; Sieben, A.; Kleinridders, A.; Morgan, D. A.; Wunderlich, F. T.; Rahmouni, K.; Kong, D. et al.; Scammell, T. E.; Lowell, B. B.; Kloppenburg, P.; Brüning, J. C.; Hausen, A. C.: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nature Communications 12, 5249 (2021)

Chowdhury, S.; Schulz, L.; Palmisano, B.; Singh, P.; Berger, J. M.; Yadav, V. K.; Mera, P.; Ellingsgaard, H.; Hidalgo, J.; Brüning, J. C. et al.; Karsenty, G.: Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. Journal of Clinical Investigation 130 (6), pp. 2888 - 2902 (2020)

Ding, X.; Willenborg, S.; Bloch, W.; Wickström, S. A.; Wagle, P.; Brodesser, S.; Roers, A.; Jais, A.; Brüning, J. C.; Hall, M. N. et al.; Rüegg, M. A.; Eming, S. A.: Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology 145 (1), pp. 283 - 300.e8 (2020)

DiToro, D.; Harbour, S. N.; Brando, J. K.; Benavides, G.; Witte, S.; Laufer, V. A.; Moseley, C.; Singer, J. R.; Frey, B.; Turner, H. et al.; Brüning, J. C.; Darley-Usmar, V.; Gao, M.; Conover, C.; Hatton, R. D.; Frank, S.; Colonna, M.; Weaver, C. T.: Insulin-Like growth factors are key regulators of T helper 17 regulatory T cell balance in autoimmunity. Immunity 52 (4), pp. 650 - 667 (2020)