Publications of Jens Claus Brüning

Journal Article (133)

21.
Journal Article
Chowdhury, S.; Schulz, L.; Palmisano, B.; Singh, P.; Berger, J. M.; Yadav, V. K.; Mera, P.; Ellingsgaard, H.; Hidalgo, J.; Brüning, J. C. et al.; Karsenty, G.: Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. Journal of Clinical Investigation 130 (6), pp. 2888 - 2902 (2020)
22.
Journal Article
Ding, X.; Willenborg, S.; Bloch, W.; Wickström, S. A.; Wagle, P.; Brodesser, S.; Roers, A.; Jais, A.; Brüning, J. C.; Hall, M. N. et al.; Rüegg, M. A.; Eming, S. A.: Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology 145 (1), pp. 283 - 300.e8 (2020)
23.
Journal Article
DiToro, D.; Harbour, S. N.; Brando, J. K.; Benavides, G.; Witte, S.; Laufer, V. A.; Moseley, C.; Singer, J. R.; Frey, B.; Turner, H. et al.; Brüning, J. C.; Darley-Usmar, V.; Gao, M.; Conover, C.; Hatton, R. D.; Frank, S.; Colonna, M.; Weaver, C. T.: Insulin-Like growth factors are key regulators of T helper 17 regulatory T cell balance in autoimmunity. Immunity 52 (4), pp. 650 - 667 (2020)
24.
Journal Article
Fischer, K.; Fenzl, A.; Liu, D.; Dyar, K. A.; Kleinert, M.; Brielmeier, M.; Clemmensen, C.; Fedl, A.; Finan, B.; Gessner, A. et al.; Jastroch, M.; Huang, J.; Keipert, S.; Klingenspor, M.; Brüning, J. C.; Kneilling, M.; Maier, F. C.; Othman, A. E.; Pichler, B. J.; Pramme-Steinwachs, I.; Sachs, S.; Scheideler, A.; Thaiss, W. M.; Uhlenhaut, H.; Ussar, S.; Woods, S. C.; Zorn, J.; Stemmer, K.; Collins, S.; Diaz-Meco, M.; Moscat, J.; Tschöp, M. H.; Müller, T. D.: The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nature Communications 11 (1), 2306 (2020)
25.
Journal Article
Jais, A.; Paeger, L.; Sotelo-Hirschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J.M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, . B.; Zeilhofer, H. U.; Backes, H.; Fenselau, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106 (6), pp. 1009 - 1025.e10 (2020)
26.
Journal Article
Jiang, H.; Gallet, S.; Klemm, P.; Scholl, P.; Folz-Donahue, K.; Altmüller, J.; Alber, J.; Heilinger, C.; Kukat, C.; Loyens, A. et al.; Müller-Fielitz, H.; Sundaram, S.; Schwaninger, M.; Prevot, V.; Brüning, J. C.: MCH neurons regulate permeability of the median eminence barrier. Neuron 107 (2), pp. 306 - 319.e9 (2020)
27.
Journal Article
Koch, C.E.; Begemann, K.; Kiehn, J.T.; Griewahn, L.; Mauer, J.; Heß, M. E.; Moser, A.; Schmid, S.M.; Brüning, J. C.; Oster, H.: Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA. Nature Communications 11 (1), 3071 (2020)
28.
Journal Article
Kohlhaas, V.; Blakemore, S. J.; Al-Maarri, M.; Nickel, N.; Pal, M.; Roth, A.; Hoevelmeyer, N.; Schäfer, S. C.; Knittel, G.; Lohneis, P. et al.; Nikolic, M.; Wiederstein, J. L.; Franitza, M.; Georgomonolis, T.; Reinart, N.; Herling, M.; Carmen, D. H.; Hartmann, E.; Rosenwald, A.; Klapper, W.; Buettner, R.; Moia, R.; Rossi, D.; Boldorini, R.; Gaidano, G.; Frenzel, L. P.; Reinhardt, H. C.; Brüning, J. C.; Hallek, M.; Krüger, M.; Peifer, M.; Pallasch, C. P.; Wunderlich, F. T.: Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. Blood (2020)
29.
Journal Article
Lippert, R. N.; Hess, S.; Klemm, P.; Burgeno, L. M.; Jahans-Price, T.; Walton, M. E.; Kloppenburg, P.; Brüning, J. C.: Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. Journal of Clinical Investigation (New York, NY) 130 (7), pp. 3761 - 3776 (2020)
30.
Journal Article
Mittenbühler, M.; Saedler, K.; Nolte, H.; Kern, L.; Zhou, J.; Qian, S.-B.; Meder, L.; Ullrich, R. T.; Brüning, J. C.; Wunderlich, F. T.: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Molecular Metabolism 42, 101085 (2020)
31.
Journal Article
Ruud, L. E.; Pereira, M. M.; de Solis, A.; Fenselau, H.; Brüning, J. C.: NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nature Communications 11 (1), 442 (2020)
32.
Journal Article
Timper, K.; Del Rio-Martin, A.; Cremer, A. L.; Bremser, S.; Alber, J.; Giavalisco, P.; Varela, L.; Heilinger, C.; Nolte, H.; Trifunovic, A. et al.; Horvath, T. L.; Kloppenburg, P.; Backes, H.; Brüning, J. C.: GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function. Cell Metabolism 31 (6), pp. 1189 - 1205.e13 (2020)
33.
Journal Article
Turpin-Nolan, S. M.; Brüning, J. C.: The role of ceramides in metabolic disorders: when size and localization matters. Nature Reviews Endocrinology 16 (4), pp. 224 - 233 (2020)
34.
Journal Article
Cheng, Y.; Luo, H.; Izzo, F.; Pickering, B. F.; Nguyen, D.; Myers, R.; Schurer, A.; Gourkanti, S.; Brüning, J. C.; Vu, L. P. et al.; Landau, D. A.; Kharas, M. G.: m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment. Cell Reports 28 (7), pp. P1703 - P1716.e6 (2019)
35.
Journal Article
Edwin Thanarajah, S.; Iglesias, S.; Kuzmanovic, B.; Rigoux, L.; Stephan, K. E.; Brüning, J. C.; Tittgemeyer, M.: Modulation of midbrain neurocircuitry by intranasal insulin. NeuroImage 194, pp. 120 - 127 (2019)
36.
Journal Article
Hammerschmidt, P.; Ostkotte, D.; Nolte, H.; Gerl, M. J.; Jais, A.; Brunner, H. L.; Sprenger, H.-G.; Awazawa, M.; Nicholls, H. T.; Turpin-Nolan, S. M. et al.; Langer, T.; Krüger, M.; Brügger, B.; Brüning, J. C.: CerS6-derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity. Cell 177 (6), pp. 1536 - 1552.e23 (2019)
37.
Journal Article
Ip, C. K.; Zhang, L.; Farzi, A.; Qi, Y.; Clarke, I.; Reed, F.; Shi, Y.-C.; Enriquez, R.; Dayas , C.; Graham, B. et al.; Begg, D.; Brüning, J. C.; Lee, N. J.; Hernandez-Sanchez, D.; Gopalasingam, G.; Koller, J.; Tasan, R.; Sperk, G.; Herzog, H.: Amygdala NPY circuits promote the development of accelerated obesity under chronic stress conditions. Cell Metabolism 30 (1), pp. 111 - 128.e6 (2019)
38.
Journal Article
Lippert, R. N.; Cremer, A. L.; Thanarajah, S. E.; Korn, C.; Jahans-Price, T.; Burgeno, L. M.; Tittgemeyer, M.; Brüning, J. C.; Walton, M. E.; Backes, H.: Time-dependent assessment of stimulus-evoked regional dopamine release. Nature Communications 10 (1), 336 (2019)
39.
Journal Article
MacVicar, T.; Ohba, Y.; Nolte, H.; Mayer, F. C.; Tatsuta, T.; Sprenger, H.-G.; Lindner, B.; Zhao, Y.; Li, J.; Bruns, C. et al.; Krüger, M.; Habich, M.; Riemer, J.; Schwarzer, R.; Pasparakis, M.; Henschke, S.; Brüning, J. C.; Zamboni, N.; Langer, T.: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature 575 (7782), pp. 361 - 365 (2019)
40.
Journal Article
Ostermann, A. L.; Wunderlich, C. M.; Schneiders, L.; Vogt, M. C.; Woeste, M.A.; Belgardt, B. F.; Niessen, C. M.; Martiny, B.; Schauss, A. C.; Frommolt, P. et al.; Nikolaev, A.; Hövelmeyer, N.; Sears, R.C.; Koch, P.J.; Günzel, D.; Brüning, J. C.; Wunderlich, F. T.: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nature Metabolism 1 (3), pp. 371 - 389 (2019)
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