Publications of Paul Klemm

Khani, S.; Topel, H.; Kardinal, R.; Tavanez, A. R.; Josephrajan, A.; Larsen, B. D. M.; Gaudry, M. J.; Leyendecker, P.; Egedal, N. M.; Güller, A. S. et al.; Stanic, N.; Ruppert, P. M.M.; Gaziano, I.; Hansmeier, N. R.; Schmidt, E.; Klemm, P.; Vagliano, L.-M.; Stahl, R.; Duthie, F.; Krause, J.-H.; Bici, A.; Engelhard, C. A.; Gohlke, S.; Frommolt, P.; Gnad, T.; Rada-Iglesias, A.; Pradas-Juni, M.; Schulz, T. J.; Wunderlich, F. T.; Pfeifer, A.; Bartelt, A.; Jastroch, M.; Wachten, D.; Kornfeld, J.-W.: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nature Metabolism 6 (6), pp. 1053 - 1075 (2024)

Sotelo-Hitschfeld, T.; Minère, M.; Klemm, P.; Borgmann, D.; Wnuk-Lipinski, D.; Jais, A.; Jia, X.; Corneliussen, S.; Kloppenburg, P.; Fenselau, H. et al.; Brüning, J. C.: GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Reports 43 (6), 114343 (2024)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35 (5), pp. 786 - 806.e13 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Steuernagel, L.; Lam, B. Y. H.; Klemm, P.; Dowsett, G. K. C.; Bauder, C. A.; Tadross, J. A.; Sotelo-Hitschfeld, T.; Del Rio-Martin, A.; Chen, W.; De Solis, A. J. et al.; Fenselau, H.; Davidsen, P.; Cimino, I.; Kohnke, S. N.; Rimmington, D.; Coll, A. P.; Beyer, A.; Yeo, G. S. H.; Brüning, J. C.: HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nature Metabolism 4 (10), pp. 1402 - 1419 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Biglari, N.; Gaziano, I.; Schumacher, J.; Radermacher, J.; Paeger, L.; Klemm, P.; Chen, W.; Corneliussen, S.; Wunderlich, C. M.; Sué, M. et al.; Vollmar, S.; Klöckener, T.; Sotelo-Hirschfeld, T.; Abbasloo, A.; Edenhofer, F.; Reimann, F.; Gribble, F. M.; Fenselau, H.; Kloppenburg, P.; Wunderlich, F. T.; Brüning, J. C.: Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nature Neuroscience 24 (7), pp. 913 - 929+ (2021)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, pp. 1662 - 1679 (2021)

Xiao, X.; Yeghiazaryan, G.; Hess, S.; Klemm, P.; Sieben, A.; Kleinridders, A.; Morgan, D. A.; Wunderlich, F. T.; Rahmouni, K.; Kong, D. et al.; Scammell, T. E.; Lowell, B. B.; Kloppenburg, P.; Brüning, J. C.; Hausen, A. C.: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nature Communications 12, 5249 (2021)

Jiang, H.; Gallet, S.; Klemm, P.; Scholl, P.; Folz-Donahue, K.; Altmüller, J.; Alber, J.; Heilinger, C.; Kukat, C.; Loyens, A. et al.; Müller-Fielitz, H.; Sundaram, S.; Schwaninger, M.; Prevot, V.; Brüning, J. C.: MCH neurons regulate permeability of the median eminence barrier. Neuron 107 (2), pp. 306 - 319.e9 (2020)

Lippert, R. N.; Hess, S.; Klemm, P.; Burgeno, L. M.; Jahans-Price, T.; Walton, M. E.; Kloppenburg, P.; Brüning, J. C.: Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. Journal of Clinical Investigation (New York, NY) 130 (7), pp. 3761 - 3776 (2020)