Talk by Dr. Wenfei Han, MPI for Biological Cybernetics, Tübingen
Gut-Brain Pathways and Parkinson’s pathology
- Datum: 14.09.2023
- Uhrzeit: 14:00 - 15:00
- Ort: MPI for Metabolism Research, Gleueler Strasse 50, 50931 Köln
- Raum: Seminar room 1
- Gastgeber: Dr. Henning Fenselau
- Kontakt: henning.fenselau@sf.mpg.de
Parkinson’s is a debilitating neurodegenerative disease affecting nearly 10 million people worldwide. The pathology appears to depend on the diffusion of abnormal aggregates of the endogenous α-synuclein protein across the nervous system. How the diffusion occurs remains controversial. Clinical evidence suggests that the gastrointestinal tract is a site of origin for α-synuclein, which then may spread to the brain. I will present studies in mice in which we tried to map the body-brain pathways via which the pathology may spread from the gut. I will also mention the potential role of gut immune cells in this process.