Publikationen von Roman K. Thomas

Li, D.; Shimamura, T.; Ji, H. B.; Chen, L.; Haringsma, H. J.; McNamara, K.; Liang, M.-C.; Perera, S. A.; Zaghlul, S.; Borgman, C. L. et al.; Kubo, S.; Takahashi, M.; Sun, Y. P.; Chirieac, L. R.; Padera, R. F.; Lindeman, N. I.; Janni, P. A.; Thomas, R. K.; Meyerson, M. L.; Eck, M. J.; Engelman, J. A.; Shapiro, G. I.; Wong, K.-K.: Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell 12 (1), S. 81 - 93 (2007)

Ji, H.; Wang, Z.; Perera, S. A.; Li, D.; Liang, M.-C.; Zaghlul, S.; McNamara, K.; Chen, L.; Albert, M.; Sun, Y. et al.; Al-Hashem, R.; Chirieac, L. R.; Padera, R.; Bronson, R. T.; Thomas, R. K.; Garraway, L. A.; Jänne, P. A.; Johnson, B. E.; Chin, L.; Wong, K.-K.: Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Research 67 (10), S. 4933 - 4939 (2007)

Draube, A.; Beyer, M.; Schumer, S.; Thomas, R. K.; von Tresckow, B.; Koslowsky, T. C.; Krieglstein, C. F.; Schultze, J. L.; Wolf, J.: Efficient activation of autologous tumor-specific T cells: a simple coculture technique of autologous dendritic cells compared to established cell fusion strategies in primary human colorectal carcinoma. Journal of Immunotherapy 30 (4), S. 359 - 369 (2007)

Thomas, R. K.; Baker, A. C.; Debiasi, R. M.; Winckler, W.; Laframboise, T.; Lin, W. M.; Wang, M.; Feng, W.; Zander, T.; Macconnaill, L. E. et al.; Lee, J. C.; Nicoletti, R.; Hatton, C.; Goyette, M.; Girard, L.; Majmudar, K.; Ziaugra, L.; Wong, K.-K.; Gabriel, S.; Beroukhim, R.; Peyton, M.; Barretina, J.; Dutt, A.; Emery, C.; Greulich, H.; Shah, K.; Sasaki, H.; Gazdar, A.; Minna, J.; Armstrong, S. A.; Mellinghoff, I. K.; Hodi, F. S.; Dranoff, G.; Mischel, P. S.; Cloughesy, T. F.; Nelson, S. F.; Liau, L. M.; Mertz, K.; Rubin, M. A.; Moch, H.; Loda, M.; Catalona, W.; Fletcher, J.; Signoretti, S.; Kaye, F.; Anderson, K. C.; Demetri, G. D.; Dummer, R.; Wagner, S.; Herlyn, M.; Sellers, W. R.; Meyerson, M.; Garraway, L. A.: High-throughput oncogene mutation profiling in human cancer. Nature Genetics 39 (3), S. 347 - 351 (2007)

Schmitz, R.; Thomas, R. K.; Harttrampf, A. C.; Wickenhauser, C.; Schultze, J. L.; Hansmann, M.-L.; Wolf, J.; Küppers, R.: The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD. International Journal of Cancer 119 (7), S. 1738 - 1740 (2006)

Tengs, T.; Lee, J. C.; Paez, J. G.; Zhao, X.; LaFramboise, T.; Giannoukos, G.; Thomas, R. K.: A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing. Cancer Letters 239 (2), S. 227 - 233 (2006)

Shimamura, T.; Ji, H.; Minami, Y.; Thomas, R. K.; Lowell, A. M.; Shah, K.; Greulich, H.; Glatt, K. A.; Meyerson, M.; Shapiro, G. I. et al.; Wong, K.-K.: Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Cancer Research 66 (13), S. 6487 - 6491 (2006)

Thomas, R. K.; Weir, B. A.; Meyerson, M.: Genomic approaches to lung cancer. Clinical Cancer Research 12 (14, P.2 Suppl.), S. 4384 - 4391 (2006)

Thomas, R. K.; Nickerson, E.; Simons, J. F.; Jänne, P. A.; Tengs, T.; Yuza, Y.; Garraway, L. A.; Laframboise, T.; Lee, J. C.; Shah, K. et al.; O'Neill, K.; Sasaki, H.; Lindeman, N.; Wong, K.-K.; Borras, A. M.; Gutmann, E. J.; Dragnev, K. H.; Debiasi, R.; Chen, T.-H.; Glatt, K. A.; Greulich, H.; Desany, B.; Lubeski, C. K.; Brockman, W.; Alvarez, P.; Hutchison, S. K.; Leamon, J. H.; Ronan, M. T.; Turenchalk, G. S.; Egholm, M.; Sellers, W. R.; Rothberg, J. M.; Meyerson, M.: Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nature Medicine 12 (7), S. 852 - 855 (2006)

Ji, H.; Zhao, X.; Yuza, Y.; Shimamura, T.; Li, D.; Protopopov, A.; Jung, B. L.; McNamara, K.; Xia, H.; Glatt, K. A. et al.; Thomas, R. K.; Sasaki, H.; Horner, J. W.; Eck, M.; Mitchell, A.; Sun, Y.; Al-Hashem, R.; Bronson, R. T.; Rabindran, S. K.; Discafani, C. M.; Maher, E.; Shapiro, G. I.; Meyerson, M.; Wong, K.-K.: Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase Iinhibitors. Proceedings of the National Academy of Sciences of the United States of America 103 (20), S. 7817 - 7822 (2006)

Thomas, R. K.; Sos, M. L.; Zander, T.; Mani, O.; Popov, A.; Berenbrinker, D.; Smola-Hess, S.; Schultze, J. L.; Wolf, J.: Inhibition of nuclear translocation of nuclear factor-kappa B despite lack of functional I kappa B alpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clinical Cancer Research 11 (22), S. 8186 - 8194 (2005)

Thomas, R. K.; Greulich, H.; Yuza, Y.; Lee, J. C.; Tengs, T.; Feng, W.; Chen, T.-H.; Nickerson, E.; Simons, J.; Egholm, M. et al.; Rothberg, J. M.; Sellers, W. R.; Meyerson, M. L.: Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harbor Symposia on Quantitative Biology 70, S. 73 - 81 (2005)