Publications of Eckhard Mandelkow

Anglada-Huguet, M.; Endepols, H.; Sydow, A.; Hilgers, R.; Neumaier, B.; Drzezga, A.; Kaniyappan, S.; Mandelkow, E.; Mandelkow, E.-M.: Reversal of Tau-dependent cognitive decay by blocking adenosine A1 receptors: Comparison of transgenic mouse models with different levels of tauopathy. International Journal of Molecular Sciences 24 (11), 9260 (2023)

Endepols, H.; Anglada-Huguet, M.; Mandelkow, E.; Schmidt, Y.; Krapf, P.; Zlatopolskiy, B. D.; Neumaier, B.; Drzezga, A.: Assessment of the in vivo relationship between cerebral hypometabolism, Tau deposition, TSPO expression, and synaptic density in a tauopathy mouse model: a multi-tracer PET study. Molecular Neurobiology 59 (6), pp. 3402 - 3413 (2022)

Green, C.; Sydow, A.; Vogel, S.; Anglada-Huguet, M.; Wiedermann, D.; Mandelkow, E.; Mandelkow, E.-M.; Höhn, M.: Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular Neurodegeneration 14, 13 (2019)

Pellkofer, H.; Ihler, F.; Weiss, B. G.; Trothe, J.; Kadavath, H.; Chongtham, M.; Kunadt, M.; Riedel, D.; Lornsen, F.; Wilken, P. et al.; Bartels, C.; Hirschel, S.; Russo, S. G.; Stransky, E.; Trojan, L.; Schmidt, B.; Mandelkow, E.; Zweckstetter, M.; Canis, M.; Schneider, A.: Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer’s disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), pp. 973 - 984 (2019)

Pir, G. J.; Choudhary, B.; Kaniyappan, S.; Chandupatla, R. R.; Mandelkow, E.; Mandelkow, E.-M.; Wang, Y.: Suppressing Tau aggregation and toxicity by an anti-aggregant Tau fragment. Molecular Neurobiology 56 (5), pp. 3751 - 3767 (2019)

Choudhary, B.; Mandelkow, E.; Mandelkow, E.-M.; Pir, G. J.: Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation. Neurobiology of Disease 117, pp. 189 - 202 (2018)

Kaniyappan, S.; Chandupatla, R. R.; Mandelkow, E.: Purification and characterization of low-n tau oligomers. Methods in Molecular Biology 1779, pp. 99 - 111 (2018)

Mari, S. A.; Wegmann, S.; Tepper, K.; Hyman, B. T.; Mandelkow, E.-M.; Mandelkow, E.; Müller, D. J.: Reversible cation-selective attachment and self-assembly of human Tau on supported brain lipid membranes. Nano Letters 18 (5), pp. 3271 - 3281 (2018)

Wegmann, S.; Eftekharzadeh, B.; Tepper, K.; Zoltowska, K. M.; Bennett, R. E.; Dujardin, S.; Laskowski, P. R.; MacKenzie, D.; Kamath, T.; Commins, C. et al.; Vanderburg, C.; Roe, A. D.; Fan, Z.; Molliex, A. M.; Hernandez-Vega, A.; Müller, D.; Hyman, A. A.; Mandelkow, E.; Taylor, J. P.; Hyman, B. T.: Tau protein liquid-liquid phase separation can initiate tau aggregation. The EMBO Journal 37 (7), e98049 (2018)

Joseph, M.; Anglada-Huguet, M.; Paesler, K.; Mandelkow, E.; Mandelkow, E.-M.: Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration 12, 88 (2017)

Pickhardt, M.; Biernat, J.; Hübschmann, S.; Dennissen, F. J.A.; Timm, T.; Aho, A.; Mandelkow, E.-M.; Mandelkow, E.: Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy. Neurobiology of Aging 57, pp. 47 - 63 (2017)

Pickhardt, M.; Lawatscheck, C.; Boerner, H. G.; Mandelkow, E.: Inhibition of Tau protein aggregation by rhodanine-based compounds solubilized via specific formulation additives to improve bioavailability and cell viability. Current Alzheimer Research 14 (7), pp. 742 - 752 (2017)

Pir, G. J.; Choudhary, B.; Mandelkow, E.: Caenorhabditis elegans models of tauopathy. The FASEB Journal 31 (12), pp. 5137 - 5148 (2017)

Sotiropoulos, I.; Galas, M.-C.; Silva, J. M.; Skoulakis, E.; Wegmann, S.; Maina, M. B.; Blum, D.; Sayas, C. L.; Mandelkow, E.-M.; Mandelkow, E. et al.; Spillantini, M. G.; Sousa, N.; Avila, J.; Medina, M.; Mudher, A.; Buee, L.: Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications 5, 91 (2017)

Xiang, S.; Kulminskaya, N.; Habenstein, B.; Biernat, J.; Tepper, K.; Paulat, M.; Griesinger, C.; Becker, S.; Lange, A.; Mandelkow, E. et al.; Linser, R.: A two-component adhesive: Tau fibrils arise from a combination of a well-defined motif and conformationally flexible interactions. Journal of the American Chemical Society 139 (7), pp. 2639 - 2646 (2017)

Zempel, H.; Dennissen, F. J.A.; Kumar, Y.; Luedtke, J.; Biernat, J.; Mandelkow, E.-M.; Mandelkow, E.: Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. The Journal of Biological Chemistry 292 (29), pp. 12192 - 12207 (2017)

Dammers, C.; Yolcu, D.; Kukuk, L.; Willbold, D.; Pickhardt, M.; Mandelkow, E.; Horn, A. H.C.; Sticht, H.; Malhis, M. N.; Will, N. et al.; Schuster, J.; Funke, S. A.: Selection and characterization of tau binding D-enantiomeric peptides with potential for therapy of Alzheimer disease. PLoS One 11 (12), e0167432 (2016)

Decker, J. M.; Krüger, L.; Sydow, A.; Dennissen, F.; Siskova, Z.; Mandelkow, E.; Mandelkow, E.-M.: The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Reports 17 (4), pp. 552 - 569 (2016)

Dennissen, F. J. A.; Anglada-Huguet, M.; Sydow, A.; Mandelkow, E.; Mandelkow, E.-M.: Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau δK280. Proceedings of the National Academy of Sciences of the United States of America 113 (41), pp. 11597 - 11602 (2016)

Gorsky, M. K.; Burnouf, S.; Dols, J.; Mandelkow, E.; Partridge, L.: Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific Reports 6, 22685 (2016)