Publications of Eva-Maria Mandelkow

Anglada-Huguet, M.; Endepols, H.; Sydow, A.; Hilgers, R.; Neumaier, B.; Drzezga, A.; Kaniyappan, S.; Mandelkow, E.; Mandelkow, E.-M.: Reversal of Tau-dependent cognitive decay by blocking adenosine A1 receptors: Comparison of transgenic mouse models with different levels of tauopathy. International Journal of Molecular Sciences 24 (11), 9260 (2023)

Decker, J. M.; Mandelkow, E.-M.: Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability? Advances in Experimental Medicine and Biology 1184, pp. 97 - 103 (2019)

Green, C.; Sydow, A.; Vogel, S.; Anglada-Huguet, M.; Wiedermann, D.; Mandelkow, E.; Mandelkow, E.-M.; Höhn, M.: Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular Neurodegeneration 14, 13 (2019)

Pir, G. J.; Choudhary, B.; Kaniyappan, S.; Chandupatla, R. R.; Mandelkow, E.; Mandelkow, E.-M.; Wang, Y.: Suppressing Tau aggregation and toxicity by an anti-aggregant Tau fragment. Molecular Neurobiology 56 (5), pp. 3751 - 3767 (2019)

Choudhary, B.; Mandelkow, E.; Mandelkow, E.-M.; Pir, G. J.: Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation. Neurobiology of Disease 117, pp. 189 - 202 (2018)

Mari, S. A.; Wegmann, S.; Tepper, K.; Hyman, B. T.; Mandelkow, E.-M.; Mandelkow, E.; Müller, D. J.: Reversible cation-selective attachment and self-assembly of human Tau on supported brain lipid membranes. Nano Letters 18 (5), pp. 3271 - 3281 (2018)

Joseph, M.; Anglada-Huguet, M.; Paesler, K.; Mandelkow, E.; Mandelkow, E.-M.: Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration 12, 88 (2017)

Pickhardt, M.; Biernat, J.; Hübschmann, S.; Dennissen, F. J.A.; Timm, T.; Aho, A.; Mandelkow, E.-M.; Mandelkow, E.: Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy. Neurobiology of Aging 57, pp. 47 - 63 (2017)

Sotiropoulos, I.; Galas, M.-C.; Silva, J. M.; Skoulakis, E.; Wegmann, S.; Maina, M. B.; Blum, D.; Sayas, C. L.; Mandelkow, E.-M.; Mandelkow, E. et al.; Spillantini, M. G.; Sousa, N.; Avila, J.; Medina, M.; Mudher, A.; Buee, L.: Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications 5, 91 (2017)

Zempel, H.; Dennissen, F. J.A.; Kumar, Y.; Luedtke, J.; Biernat, J.; Mandelkow, E.-M.; Mandelkow, E.: Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. The Journal of Biological Chemistry 292 (29), pp. 12192 - 12207 (2017)

Zempel, H.; Luedtke, J.; Mandelkow, E.-M.: Tracking Tau in neurons: How to transfect and track exogenous tau into primary neurons. Methods in Molecular Biology 1523, pp. 335 - 340 (2017)

Zempel, H.; Mandelkow, E.-M.: Tracking Tau in neurons: How to grow, fix, and stain primary neurons for the investigation of Tau in all developmental stages. Methods in Molecular Biology 1523, pp. 327 - 334 (2017)

Decker, J. M.; Krüger, L.; Sydow, A.; Dennissen, F.; Siskova, Z.; Mandelkow, E.; Mandelkow, E.-M.: The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Reports 17 (4), pp. 552 - 569 (2016)

Dennissen, F. J. A.; Anglada-Huguet, M.; Sydow, A.; Mandelkow, E.; Mandelkow, E.-M.: Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau δK280. Proceedings of the National Academy of Sciences of the United States of America 113 (41), pp. 11597 - 11602 (2016)

Krüger, L.; Mandelkow, E.-M.: Tau neurotoxicity and rescue in animal models of human Tauopathies. Current Opinion in Neurobiology 36, 1592, pp. 52 - 58 (2016)

Pir, G. J.; Choudhary, B.; Mandelkow, E.; Mandelkow, E.-M.: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model. Molecular Neurodegeneration 11 (1), 96 (2016)

Sydow, A.; Hochgräfe, K.; Koenen, S.; Cadinu, D.; Matenia, D.; Petrova, O.; Joseph, M.; Dennissen, F. J.; Mandelkow, E.-M.: Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD. Acta Neuropathologica Communications 4, 17 (2016)

Pickhardt, M.; Neumann, T.; Schwizer, D.; Callaway, K.; Vendruscolo, M.; Schenk, D.; St. George-Hyslop, P.; Mandelkow, E.-M.; Dobson, C.; McConlogue, L. et al.; Mandelkow, E.; Toth, G.: Identification of small molecule inhibitors of tau aggregation by targeting monomeric tau as a potential therapeutic approach for tauopathies. Current Alzheimer Research 12 (9), pp. 814 - 828 (2015)

Saidi, L.-J.; Polydoro, M.; Kay, K. R.; Sanchez, L.; Mandelkow, E.-M.; Hyman, B. T.; Spires-Jones, T. L.: Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease 44 (3), pp. 937 - 947 (2015)

Shammas, S. L.; Garcia, G. A.; Kumar, S.; Kjaergaard, M.; Horrocks, M. H.; Shivji, N.; Mandelkow, E.-M.; Mandelkow, E.; Klenerman, D.: A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications 6, 7025 (2015)