Publications of Jens Claus Brüning

Paeger, L.; Pippow, A.; Hess, S.; Paehler, M.; Klein, A. C.; Husch, A.; Pouzat, C.; Brüning, J. C.; Kloppenburg, P.: Energy imbalance alters Ca2+ handling and excitability of POMC neurons. eLife 6, e25641 (2017)

Riera, C. E.; Tsaousidou, E.; Halloran, J.; Follett, P.; Hahn, O.; Pereira, M.; Ruud, L. E.; Alber, J.; Tharp, K.; Anderson, C. M. et al.; Brönneke, H. S.; Hampel, B.; de Magalhaes Filho, C. D.; Stahl, A.; Brüning, J. C.; Dillin, A.: The sense of smell impacts metabolic health and obesity. Cell Metabolism 26 (1), pp. 198 - 211 (2017)

Ruud, J.; Steculorum, S. M.; Brüning, J. C.: Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nature Communications 8, 15259 (2017)

Steculorum, S. M.; Timper, K.; Engström Ruud, L.; Evers, N.; Paeger, L.; Bremser, S.; Kloppenburg, P.; Brüning, J. C.: Inhibition of P2Y6 signaling in AgRP neurons reduces food intake and improves systemic insulin sensitivity in obesity. Cell Reports 18 (7), pp. 1587 - 1597 (2017)

Theurich, S.; Tsaousidou, E.; Hanssen, R.; Lempradl, A. M.; Mauer, J.; Timper, K.; Schilbach, K.; Folz-Donahue, K.; Heilinger, C.; Sexl, V. et al.; Pospisilik, J. A.; Wunderlich, F. T.; Brüning, J. C.: IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis. Cell Metabolism 26 (1), pp. 171 - 184 (2017)

Timper, K.; Brüning, J. C.: Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Disease Models and Mechanisms 10 (6), pp. 679 - 689 (2017)

Timper, K.; Denson, J. L.; Steculorum, S. M.; Heilinger, C.; Engström-Ruud, L.; Wunderlich, C. M.; Rose-John, S.; Wunderlich, F. T.; Brüning, J. C.: IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling. Cell Reports 19 (2), pp. 267 - 280 (2017)

Xu, E.; Pereira, M. M.; Karakasilioti, I.; Theurich, S.; Al-Maari, M.; Rappl, G.; Waisman, A.; Wunderlich, F. T.; Brüning, J. C.: Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nature Communications 8, 14803 (2017)

Burnett, C. J.; Li, C.; Webber, E.; Tsaousidou, E.; Xue, S. Y.; Brüning, J. C.; Krashes, M. J.: Hunger-driven motivational state competition. Neuron 92 (1), pp. 187 - 201 (2016)

Duteil, D.; Tosic, M.; Lausecker, F.; Nenseth, H. Z.; Müller, J. M.; Urban, S.; Willmann, D.; Petroll, K.; Messaddeq, N.; Arrigoni, L. et al.; Manke, T.; Kornfeld, J.-W.; Brüning, J. C.; Zagoriy, V.; Meret, M.; Dengjiel, J.; Kanouni, T.; Schüle, R.: Lsd1 ablation triggers metabolic reprogramming of Brown adipose tissue. Cell Reports 17 (4), pp. 1008 - 1021 (2016)

Hausen, A. C.; Ruud, J.; Jiang, H.; Hess, S.; Varbanov, H.; Kloppenburg, P.; Brüning, J. C.: Insulin-dependent activation of MCH neurons impairs locomotor activity and insulin sensitivity in obesity. Cell Reports 17 (10), pp. 2512 - 2521 (2016)

Jais, A.; Solas, M.; Backes, H.; Chaurasia, B.; Kleinridders, A.; Theurich, S.; Mauer, J.; Steculorum, S. M.; Hampel, B.; Goldau, J. et al.; Alber, J.; Förster, C. Y.; Eming, S. A.; Schwaninger, M.; Ferrara, N.; Karsenty, G.; Brüning, J. C.: Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165 (4), pp. 882 - 895 (2016)

Kühn, A. B.; Feis, D.-L.; Schilbach, L.; Kracht, L. W.; Heß, M. E.; Mauer, J.; Brüning, J. C.; Tittgemeyer, M.: FTO gene variant modulates the neural correlates of visual food perception. NeuroImage 128, pp. 21 - 31 (2016)

Oliverio, M.; Schmidt, E.; Mauer, J.; Baitzel, C.; Hansmeier, N.; Khani, S.; Konieczka, S.; Pradas-Juni, M.; Brodesser, S.; Van, T.-M. et al.; Bartsch, D.; Brönneke, H. S.; Heine, M.; Hilpert, H.; Tarcitano, E.; Garinis, G. A.; Frommolt, P.; Heeren, J.; Mori, M. A.; Brüning, J. C.; Kornfeld, J.-W.: Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nature Cell Biology 18 (3), pp. 328 - 336 (2016)

Ruud, J.; Brüning, J. C.: Neuroendocrinology: Electromagnetogenetic control over feeding and glucose metabolism. Current Biology 26 (11), pp. R470 - R473 (2016)

Schmitz, J.; Evers, N.; Awazawa, M.; Nicholls, H. T.; Brönneke, H. S.; Dietrich, A.; Mauer, J.; Blüher, M.; Brüning, J. C.: Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Molecular Metabolism 5 (5), pp. 328 - 339 (2016)

Steculorum, S. M.; Brüning, J. C.: Sweet mitochondrial dynamics in VMH neurons. Cell Metabolism 23 (4), pp. 577 - 579 (2016)

Steculorum, S. M.; Ruud, J.; Karakasilioti, I.; Backes, H.; Engström Ruud, L.; Timper, K.; Heß, M. E.; Tsaousidou, E.; Mauer, J.; Vogt, M. C. et al.; Paeger, L.; Bremser, S.; Klein, A. C.; Morgan, D. A.; Frommolt, P.; Brinkkötter, P. T.; Hammerschmidt, P.; Benzing, T.; Rahmouni, K.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue. Cell 165 (1), pp. 125 - 138 (2016)

Wilhelm, K.; Happel, K.; Eelen, G.; Schoors, S.; Oellerich, M. F.; Lim, R.; Zimmermann, B.; Aspalter, I. M.; Franco, C. A.; Boettger, T. et al.; Braun, T.; Fruttiger, M.; Rajewsky, K.; Keller, C.; Brüning, J. C.; Gerhardt, H.; Carmeliet, P.; Potente, M.: FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature 529 (7585), pp. 216 - 220 (2016)

Chong, A. C. N.; Vogt, M. C.; Hill, A. S.; Brüning, J. C.; Zeltser, L. M.: Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness. Molecular Metabolism 4 (2), pp. 83 - 92 (2015)