Publications of Frank Thomas Wunderlich

Jais, A.; Paeger, L.; Sotelo-Hitschfeld, T.; Bremser, S.; Prinzensteiner, M.; Klemm, P.; Mykytiuk, V.; Widdershooven, P. J.M.; Vesting, A. J.; Grzelka, K. et al.; Minère, M.; Cremer, A. L.; Xu, J.; Korotkova, T.; Lowell, B. B.; Zeilhofer, H. U.; Fenselau, H.; Backes, H.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106 (6), pp. 1009 - 1025.e10 (2020)

Liedtke, K.; Alter, C.; Günther, A.; Hövelmeyer, N.; Klopfleisch, R.; Naumann, R.; Wunderlich, F. T.; Buer, J.; Westendorf, A. M.; Hansen, W.: Endogenous CD83 expression in CD4+ conventional T cells controls inflammatory immune responses. Journal of Immunology; American Association of Immunologists, Bethesda, USA 204 (12), pp. 3217 - 3226 (2020)

Mehrjardi, N. Z.; Molcanyi, M.; Hatay, F. F.; Timmer, M.; Shahbazi, E.; Ackermann, J. P.; Herms, S.; Heilmann-Heimbach, S.; Wunderlich, F. T.; Prochnow, N. et al.; Haghikia, A.; Lampert, A.; Hescheler, J.; Neugebauer, E. A.M.; Baharvand, H.; Saric, T.: Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo. Cell Proliferation 53, e12892 (2020)

Mittenbühler, M.; Saedler, K.; Nolte, H.; Kern, L.; Zhou, J.; Qian, S.-B.; Meder, L.; Ullrich, R. T.; Brüning, J. C.; Wunderlich, F. T.: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Molecular Metabolism 42, 101085 (2020)

Mufazolov, I. A.; Andruszewski, D.; Schelmbauer, C.; Heink, S.; Blanfeld, M.; Masri, J.; Tang, Y.; Schüler, R.; Eich, C.; Wunderlich, F. T. et al.; Karbach, S. H.; Bluestone, J. A.; Korn, T.; Waisman, A.: Cutting edge: IL-6-driven immune dysregulation is strictly dependent on IL-6R a-chain expression. Journal of Immunology 204 (4), pp. 747 - 751 (2020)

Riabinska, A.; Lehrmann, D.; Jachimowicz, R. D.; Knittel, G.; Fritz, C.; Schmitt, A.; Geyer, A.; Heneweer, C.; Wittersheim, M.; Frenzel, L. P. et al.; Torgovnick, A.; Wiederstein, J. L.; Wunderlich, C. M.; Ortmann, M.; Paillard, A.; Wößmann, W.; Borkhardt, A.; Burdach, S.; Hansmann, M.-L.; Rosenwald, A.; Perner, S.; Mall, G.; Klapper, W.; Merseburg, A.; Krüger, M.; Grüll, H.; Persigehl, T.; Wunderlich, F. T.; Peifer, M.; Utermöhlen, O.; Büttner, R.; Beleggia, F.; Reinhardt, H. C.: ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 34 (3), pp. 771 - 786 (2020)

Kern, L.; Mittenbühler, M.; Vesting, A. J.; Ostermann, A. L.; Wunderlich, C. M.; Wunderlich, F. T.: Obesity-induced TNF alpha and IL-6 signaling: The missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers 11 (1), 24 (2019)

Lahmann, I.; Bröhl, D.; Zyrianova, T.; Isomura, A.; Czajkowski, M. T.; Kapoor, V.; Griger, J.; Ruffault, P.-L.; Mademtzoglou, D.; Zammit, P. S. et al.; Wunderlich, F. T.; Spuler, S.; Kühn, R.; Preibisch, S.; Wolf, J.; Kageyama, R.; Birchmeier, C.: Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells. Genes and Development 33 (9-10), pp. 524 - 535 (2019)

Ostermann, A. L.; Wunderlich, C. M.; Schneiders, L.; Vogt, M. C.; Woeste, M.A.; Belgardt, B. F.; Niessen, C. M.; Martiny, B.; Schauss, A. C.; Frommolt, P. et al.; Nikolaev, A.; Hövelmeyer, N.; Sears, R.C.; Koch, P.J.; Günzel, D.; Brüning, J. C.; Wunderlich, F. T.: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nature Metabolism 1 (3), pp. 371 - 389 (2019)

Scherger, A. K.; Al-Maarri, M.; Maurer, H. C.; Schick, M.; Maurer, S.; Öllinger, R.; Gonzalez-Menendez, I.; Martella, M.; Thaler, M.; Pechloff, K. et al.; Steiger, K.; Sander, S.; Ruland, J.; Rad, R.; Quintanilla-Martinez, L.; Wunderlich, F. T.; Rose-John, S.; Keller, U.: Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma. JCI Insight 4 (15), e128435 (2019)

Schmidleithner, L.; Thabet, Y.; Schönfeld, E.; Köhne, M.; Sommer, D.; Abdullah, Z.; Sadlon, T.; Osei-Sarpong, C.; Subbaramaiah, K.; Copperi, F. et al.; Haendler, K.; Varga, T.; Schanz, O.; Bourry, S.; Bassler, K.; Krebs, W.; Peters, A. E.; Baumgart, A.-K.; Schneeweiss, M.; Klee, K.; Schmidt, S. V.; Nüssing, S.; Sander, J.; Ohkura, N.; Waha, A.; Sparwasser, T.; Wunderlich, F. T.; Förster, I.; Ulas, T.; Weighardt, H.; Sakaguchi, S.; Pfeifer, A.; Blüher, M.; Dannenberg, A. J.; Ferreiros, N.; Muglia, L. J.; Wickenhauser, C.; Barry, S. C.; Schultze, J. L.; Beyer, M.: Enzymatic activity of HPGD in Treg cells suppresses Tconv cells to maintain adipose tissue homeostasis and prevent metabolic dysfunction. Immunity 50 (5), pp. 1232 - 1248.e14 (2019)

Dafinger, C.; Rinschen, M. M.; Borgal, L.; Ehrenberg, C.; Basten, S. G.; Franke, M.; Hoehne, M.; Rauh, M.; Goebel, H.; Bloch, W. et al.; Wunderlich, F. T.; Peters, D. J.M.; Tasche, D.; Mishra, T.; Habbig, S.; Dötsch, J.; Müller, R.-U.; Brüning, J. C.; Persigehl, T.; Giles, R. H.; Benzing, T.; Schermer, B.; Liebau, M. C.: Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Experimental and Molecular Medicine 50, 75 (2018)

Hahn, M.; Buerckert, J.-P.; Luttenberger, C.A.; Klebow, S.; Hess, M.E.; Al-Maarri, M.; Vogt, M. C.; Reißig, S.; Hallek, M.; Wienecke-Baldacchino, A. et al.; Buch, T.; Muller, C.P.; Pallasch, C.P.; Wunderlich, F. T.; Waisman, A.; Hoevelmeyer, N.: Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappa B signaling. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 32 (1), pp. 72 - 82 (2018)

Mittenbühler, M.; Sprenger, H.-G.; Gruber, S.; Wunderlich, C. M.; Kern, L.; Brüning, J. C.; Wunderlich, F. T.: Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma. Molecular Metabolism 17, pp. 122 - 133 (2018)

Wunderlich, C. M.; Ackermann, J. P.; Ostermann, A. L.; Adams-Quack, P.; Vogt, M. C.; Tran, M.-L.; Nikolajev, A.; Waisman, A.; Garbers, C.; Theurich, S. et al.; Mauer, J.; Hövelmeyer, N.; Wunderlich, F. T.: Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nature Communications 9 (1), 1646 (2018)

Awazawa, M.; Gabel, P.; Tsaousidou, E.; Nolte, H.; Krüger, M.; Schmitz, J.; Ackermann, J. P.; Brandt, C.; Altmueller, J.; Motameny, S. et al.; Wunderlich, F. T.; Kornfeld, J.-W.; Blüher, M.; Brüning, J. C.: A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nature Medicine 23 (12), pp. 1466 - 1473 (2017)

Bergmann, J.; Müller, M.; Baumann, N.; Reichert, M.; Heneweer, C.; Bolik, J.; Lücke, K.; Gruber, S.; Carambia, A.; Boretius, S. et al.; Leuschner, I.; Becker, T.; Rabe, B.; Herkel, J.; Wunderlich, F. T.; Mittrücker, H.-W.; Rose-John, S.; Schmidt-Arras, D.: IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice. Hepatology 65 (1), pp. 89 - 103 (2017)

Drees, C.; Vahl, J. C.; Bortoluzzi, S.; Heger, K.; Fischer, J. C.; Wunderlich, F. T.; Peschel, C.; Schmidt-Supprian, M.: Roquin paralogs differentially regulate functional NKT cell subsets. Journal of Immunology 198 (7), pp. 2747 - 2759 (2017)

Heink, S.; Yogev, N.; Garbers, C.; Herwerth, M.; Aly, L.; Gasperi, C.; Husterer, V.; Croxford, A. L.; Möller-Hackbarth, K.; Bartsch, H. S. et al.; Sotlar, K.; Krebs, S.; Regen, T.; Blum, H.; Hemmer, B.; Misgeld, T.; Wunderlich, F. T.; Hidalgo, J.; Oukka, M.; Rose-John, S.; Schmidt-Supprian, M.; Waisman, A.; Korn, T.: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T H 17 cells. Nature Immunology 18 (1), pp. 74 - 85 (2017)

Knittel, G.; Rehkämper, T.; Korovkina, D.; Liedgens, P.; Fritz, C.; Torgovnick, A.; Al-Baldawi, Y.; Al-Maarri, M.; Cun, Y.; Fedorchenko, O. et al.; Riabinska, A.; Beleggia, F.; Nguyen, P.-H.; Wunderlich, F. T.; Ortmann, M.; Montesinos-Rongen, M.; Tausch, E.; Stilgenbauer, S.; Frenzel, L.; Herling, M.; Herling, C.; Bahlo, J.; Hallek, M.; Peifer, M.; Buettner, R.; Persigehl, T.; Reinhardt, H. C.: Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nature Communications 8 (1), 153 (2017)