Publications of Jens Claus Brüning

Zhou, J.; Wan, J.; Shu, X. E.; Heß, M. E.; Brüning, J. C.; Qian, S.-B.: N6-Methyladenosine guides mRNA alternative translation during integrated stress response. Molecular Cell 69 (4), pp. 636 - 647.e7 (2018)

Awazawa, M.; Gabel, P.; Tsaousidou, E.; Nolte, H.; Krüger, M.; Schmitz, J.; Ackermann, J. P.; Brandt, C.; Altmueller, J.; Motameny, S. et al.; Wunderlich, F. T.; Kornfeld, J.-W.; Blüher, M.; Brüning, J. C.: A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nature Medicine 23 (12), pp. 1466 - 1473 (2017)

Braune, J.; Weyer, U.; Hobusch, C.; Mauer, J.; Brüning, J. C.; Bechmann, I.; Gericke, M.: IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity. The Journal of Immunology 198 (7), pp. 2927 - 2934 (2017)

Dodd, G. T.; Andrews, Z. B.; Simonds, S. E.; Michael, N. J.; DeVeer, M.; Brüning, J. C.; Spanswick, D.; Cowley, M. A.; Tiganis, T.: A hypothalamic phosphatase switch coordinates energy expenditure with feeding. Cell Metabolism 26 (2), pp. 375 - 393 (2017)

Fritsche, A.; Heni, M.; Gancheva, S.; Preißl, H.; Kullmann, S.; Lehnert, H.; Hallschmid, M.; Tschöp, M. H.; Brüning, J. C.; Roden, M. et al.; Häring, H.-U.: Das Gehirn als Schaltzentrale des Stoffwechsels. Diabetes Aktuell 15 (3), pp. 109 - 111 (2017)

Jais, A.; Brüning, J. C.: Hypothalamic inflammation in obesity and metabolic disease. The Journal of Clinical Investigation 127 (1), pp. 24 - 32 (2017)

Loh, K.; Zhang, L.; Brandon, A.; Wang, Q.; Begg, D.; Qi, Y.; Fu, M.; Kulkarni, R.; Teo, J.; Baldock, P. et al.; Brüning, J. C.; Cooney, G.; Neely, G. G.; Herzog, H.: Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism 6 (6), pp. 574 - 584 (2017)

Paeger, L.; Karakasilioti, I.; Altmueller, J.; Frommole, P.; Brüning, J. C.; Kloppenburg, P.: Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife 6, e25770 (2017)

Paeger, L.; Pippow, A.; Hess, S.; Paehler, M.; Klein, A. C.; Husch, A.; Pouzat, C.; Brüning, J. C.; Kloppenburg, P.: Energy imbalance alters Ca2+ handling and excitability of POMC neurons. eLife 6, e25641 (2017)

Riera, C. E.; Tsaousidou, E.; Halloran, J.; Follett, P.; Hahn, O.; Pereira, M.; Ruud, L. E.; Alber, J.; Tharp, K.; Anderson, C. M. et al.; Brönneke, H. S.; Hampel, B.; de Magalhaes Filho, C. D.; Stahl, A.; Brüning, J. C.; Dillin, A.: The sense of smell impacts metabolic health and obesity. Cell Metabolism 26 (1), pp. 198 - 211 (2017)

Ruud, J.; Steculorum, S. M.; Brüning, J. C.: Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nature Communications 8, 15259 (2017)

Steculorum, S. M.; Timper, K.; Engström Ruud, L.; Evers, N.; Paeger, L.; Bremser, S.; Kloppenburg, P.; Brüning, J. C.: Inhibition of P2Y6 signaling in AgRP neurons reduces food intake and improves systemic insulin sensitivity in obesity. Cell Reports 18 (7), pp. 1587 - 1597 (2017)

Theurich, S.; Tsaousidou, E.; Hanssen, R.; Lempradl, A. M.; Mauer, J.; Timper, K.; Schilbach, K.; Folz-Donahue, K.; Heilinger, C.; Sexl, V. et al.; Pospisilik, J. A.; Wunderlich, F. T.; Brüning, J. C.: IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis. Cell Metabolism 26 (1), pp. 171 - 184 (2017)

Timper, K.; Brüning, J. C.: Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Disease Models and Mechanisms 10 (6), pp. 679 - 689 (2017)

Timper, K.; Denson, J. L.; Steculorum, S. M.; Heilinger, C.; Engström-Ruud, L.; Wunderlich, C. M.; Rose-John, S.; Wunderlich, F. T.; Brüning, J. C.: IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling. Cell Reports 19 (2), pp. 267 - 280 (2017)

Xu, E.; Pereira, M. M.; Karakasilioti, I.; Theurich, S.; Al-Maari, M.; Rappl, G.; Waisman, A.; Wunderlich, F. T.; Brüning, J. C.: Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nature Communications 8, 14803 (2017)

Burnett, C. J.; Li, C.; Webber, E.; Tsaousidou, E.; Xue, S. Y.; Brüning, J. C.; Krashes, M. J.: Hunger-driven motivational state competition. Neuron 92 (1), pp. 187 - 201 (2016)

Duteil, D.; Tosic, M.; Lausecker, F.; Nenseth, H. Z.; Müller, J. M.; Urban, S.; Willmann, D.; Petroll, K.; Messaddeq, N.; Arrigoni, L. et al.; Manke, T.; Kornfeld, J.-W.; Brüning, J. C.; Zagoriy, V.; Meret, M.; Dengjiel, J.; Kanouni, T.; Schüle, R.: Lsd1 ablation triggers metabolic reprogramming of Brown adipose tissue. Cell Reports 17 (4), pp. 1008 - 1021 (2016)

Hausen, A. C.; Ruud, J.; Jiang, H.; Hess, S.; Varbanov, H.; Kloppenburg, P.; Brüning, J. C.: Insulin-dependent activation of MCH neurons impairs locomotor activity and insulin sensitivity in obesity. Cell Reports 17 (10), pp. 2512 - 2521 (2016)

Jais, A.; Solas, M.; Backes, H.; Chaurasia, B.; Kleinridders, A.; Theurich, S.; Mauer, J.; Steculorum, S. M.; Hampel, B.; Goldau, J. et al.; Alber, J.; Förster, C. Y.; Eming, S. A.; Schwaninger, M.; Ferrara, N.; Karsenty, G.; Brüning, J. C.: Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165 (4), pp. 882 - 895 (2016)