Publications

Izawa, S.; Fusca, D.; Jiang, H.; Heilinger, C.; Hausen, A. C.; Wunderlich, F. T.; Steuernagel, L.; Kloppenburg, P.; Brüning, J. C.: Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity. Cell Reports 44, 115277, p. 115277 (2025)

Jiao, Z.; Gao, T.; Wang, X.; Wang, A.; Ma, Y.; Feng, L.; Gao, L.; Gou, L.; Zhang, W.; Biglari, N. et al.; Boxer, E. E.; Steuernagel, L.; Ding, X.; Yu, Z.; Li, M.; Gao, M.; Hao, M.; Zhou, H.; Cao, X.; Li, S.; Jiang, T.; Qi, J.; Jia, X.; Feng, Z.; Ren, B.; Chen, Y.; Shi, X.; Wang, D.; Wang, X.; Han, L.; Liang, Y.; Qian, L.; Jin, C.; Huang, J.; Deng, W.; Wang, C.; Li, E.; Hu, Y.; Tao, Z.; Li, H.; Yu, X.; Xu, M.; Chang, H.-C.; Zhang, Y.; Xu, H.; Yan, J.; Li, A.; Luo, Q.; Stoop, R.; Sternson, S. M.; Brüning, J. C.; Anderson, D. J.; Poo, M.-m.; Sun, Y.; Xu, S.; Gong, H.; Sun, Y.-G.; Xu, X.: Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nature Neuroscience 28, pp. 1073 - 1088 (2025)

Solheim, M. H.; Stroganov, S.; Chen, W.; Subagia, P. S.; Bauder, C. A.; Wnuk-Lipinski, D.; Del Río-Martín, A.; Sotelo-Hitschfeld, T.; Beddows, C. A.; Klemm, P. et al.; Dodd, G. T.; Lundh, S.; Secher, A.; Wunderlich, F. T.; Steuernagel, L.; Brüning, J. C.: Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis. Cell 188, pp. 3550 - 3566.e22 (2025)

Tadross, J. A.; Steuernagel, L.; Dowsett, G. K. C.; Kentistou, K. A.; Lundh, S.; Porniece, M.; Klemm, P.; Rainbow, K.; Hvid, H.; Kania, K. et al.; Polex-Wolf, J.; Knudsen, L. B.; Pyke, C.; Perry, J. R. B.; Lam, B. Y. H.; Brüning, J. C.; Yeo, G. S. H.: A comprehensive spatio-cellular map of the human hypothalamus. Nature 639, pp. 708 - 716 (2025)

Tadross, J. A.; Steuernagel, L.; Dowsett, G. K. C.; Kentistou, K. A.; Lundh, S.; Porniece, M.; Klemm, P.; Rainbow, K.; Hvid, H.; Kania, K. et al.; Polex-Wolf, J.; Knudsen, L. B.; Pyke, C.; Perry, J. R. B.; Lam, B. Y. H.; Brüning, J. C.; Yeo, G. S. H.: Author Correction: A comprehensive spatio-cellular map of the human hypothalamus. Nature 639, p. E17 - E17 (2025)

Zhu, Y.; Mehlkop, O.; Backes, H.; Cremer, A. L.; Porniece, M.; Klemm, P.; Steuernagel, L.; Chen, W.; Johnen, R.; Wunderlich, F. T. et al.; Jais, A.; Brüning, J. C.: Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling. Cell Reports 44, 115522, p. 115522 (2025)

de Solis, A. J.; Del Rio-Martin, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A. L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 6 (3), pp. 473 - 493 (2024)

Dodt, S.; Widdershooven, N. V.; Dreisow, M.-L.; Weiher, L.; Steuernagel, L.; Wunderlich, F. T.; Brüning, J. C.; Fenselau, H.: NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 15 (1), 5439 (2024)

Leon, S.; Simon, V.; Lee, T. H.; Steuernagel, L.; Clark, S.; Biglari, N.; Lesté-Lassere, T.; Dupuy, N.; Cannich, A.; Bellocchio, L. et al.; Zizzari, P.; Allard, C.; Gonzales, D.; Le Feuvre, Y.; Lhuillier, E.; Brochard, A.; Nicolas, J. C.; Teillon, J.; Nikolski, M.; Marsicano, G.; Fioramonti, X.; Brüning, J. C.; Cota, D.; Quarta, C.: Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity. Nature Communications 15, 3443 (2024)

Zhou, X.; Stine, C.; Prada, P. O. d.; Fusca, D.; Assoumou, K.; Dernic, J.; Bhat, M. A.; Achanta, A. S.; Johnson, J. C.; Pasqualini, A. L. et al.; Jadhav, S.; Bauder, C. A.; Steuernagel, L.; Ravotto, L.; Benke, D.; Weber, B.; Suko, A.; Palmiter, R. D.; Stoeber, M.; Kloppenburg, P.; Brüning, J. C.; Bruchas, M. R.; Patriarchi, T.: Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release. Nature Communications 15 (1), 5353 (2024)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35 (5), pp. 786 - 806.e13 (2023)

Hammerschmidt, P.; Steculorum, S. M.; Bandet, C. L.; Del Rio-Martin, A.; Steuernagel, L.; Kohlhaas, V.; Feldmann, M.; Varela, L.; Majcher, A.; Quatorze Correia, M. et al.; Klar, R. F.U.; Bauder, C. A.; Kaya, E.; Porniece, M.; Biglari, N.; Sieben, A.; Horvath, T. L.; Hornemann, T.; Brodesser, S.; Brüning, J. C.: CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications 14 (1), 7824 (2023)

Gaziano, I.; Corneliussen, S.; Biglari, N.; Neuhaus, R.; Shen, L.; Sotelo-Hitschfeld, T.; Klemm, P.; Steuernagel, L.; de Solis, A.; Chen, W. et al.; Wunderlich, F. T.; Kloppenburg, P.; Brüning, J. C.: Dopamine-inhibited POMCDrd2+neurons in the ARC acutely regulate feeding and body temperature. JCI Insight 7 (21), e162753 (2022)

Steuernagel, L.; Lam, B. Y. H.; Klemm, P.; Dowsett, G. K. C.; Bauder, C. A.; Tadross, J. A.; Sotelo-Hitschfeld, T.; Del Rio-Martin, A.; Chen, W.; De Solis, A. J. et al.; Fenselau, H.; Davidsen, P.; Cimino, I.; Kohnke, S. N.; Rimmington, D.; Coll, A. P.; Beyer, A.; Yeo, G. S. H.; Brüning, J. C.: HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nature Metabolism 4 (10), pp. 1402 - 1419 (2022)

Vesting, A. J.; Jais, A.; Klemm, P.; Steuernagel, L.; Wienand, P.; Fog-Tonnesen, M.; Hvid, H.; Schumacher, A.-L.; Kukat, C.; Nolte, H. et al.; Georgomanolis, T.; Altmüller, J.; Pasparakis, M.; Schmidt, A.; Krüger, M.; Supprian, M. S.; Waisman, A.; Straub, B. K.; Raschzok, N.; Bernier, M.; Birkenfeld, A. L.; Hövelmeyer, N.; Brüning, J. C.; Wunderlich, F. T.: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism 66, 101626 (2022)

Kumar, M. P.; Cremer, A. L.; Klemm, P.; Steuernagel, L.; Sundaram, S.; Jais, A.; Hausen, A. C.; Tao, J.; Secher, A.; Pedersen, T. A. et al.; Schwaninger, M.; Wunderlich, F. T.; Lowell, B. B.; Backes, H.; Brüning, J. C.: Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nature Metabolism 3, pp. 1662 - 1679 (2021)

Steuernagel, L.; Meckbach, C.; Heinrich, F.; Zeidler, S.; Schmitt, A. O.; Gültas, M.: Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues. PLOS ONE 14, p. e0216475 (2019)