Publications of Jens Claus Brüning

Ip, C. K.; Zhang, L.; Farzi, A.; Qi, Y.; Clarke, I.; Reed, F.; Shi, Y.-C.; Enriquez, R.; Dayas , C.; Graham, B. et al.; Begg, D.; Brüning, J. C.; Lee, N. J.; Hernandez-Sanchez, D.; Gopalasingam, G.; Koller, J.; Tasan, R.; Sperk, G.; Herzog, H.: Amygdala NPY circuits promote the development of accelerated obesity under chronic stress conditions. Cell Metabolism 30 (1), pp. 111 - 128.e6 (2019)

Lippert, R. N.; Cremer, A. L.; Thanarajah, S. E.; Korn, C.; Jahans-Price, T.; Burgeno, L. M.; Tittgemeyer, M.; Brüning, J. C.; Walton, M. E.; Backes, H.: Time-dependent assessment of stimulus-evoked regional dopamine release. Nature Communications 10 (1), 336 (2019)

MacVicar, T.; Ohba, Y.; Nolte, H.; Mayer, F. C.; Tatsuta, T.; Sprenger, H.-G.; Lindner, B.; Zhao, Y.; Li, J.; Bruns, C. et al.; Krüger, M.; Habich, M.; Riemer, J.; Schwarzer, R.; Pasparakis, M.; Henschke, S.; Brüning, J. C.; Zamboni, N.; Langer, T.: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature 575 (7782), pp. 361 - 365 (2019)

Ostermann, A. L.; Wunderlich, C. M.; Schneiders, L.; Vogt, M. C.; Woeste, M.A.; Belgardt, B. F.; Niessen, C. M.; Martiny, B.; Schauss, A. C.; Frommolt, P. et al.; Nikolaev, A.; Hövelmeyer, N.; Sears, R.C.; Koch, P.J.; Günzel, D.; Brüning, J. C.; Wunderlich, F. T.: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer. Nature Metabolism 1 (3), pp. 371 - 389 (2019)

Raichur, S.; Brunner, B.; Bielohuby, M.; Hansen, G.; Pfenninger, A.; Wang, B.; Brüning, J. C.; Larsen, P. J.; Tennagels, N.: The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach. Molecular Metabolism 21, pp. 36 - 50 (2019)

Ruud, J.; Alber, J.; Tokarska, A.; Engström Ruud, L.; Nolte, H.; Biglari, N.; Lippert, R. N.; Lautenschlager, Ä.; Cieslak, P. E.; Szumiec, L. et al.; Hess, M. E.; Brönneke, H. S.; Krüger, M.; Nissbrandt, H.; Korotkova, T.; Silberberg, G.; Rodriguez Parkitna, J.; Brüning, J. C.: The Fat mass and obesity-associated protein (FTO) regulates locomotor responses to novelty via D2R medium spiny neurons. Cell Reports 27 (11), pp. 3182 - 3198.e9 (2019)

Thanarajah, S. E.; Backes, H.; DiFeliceantonio, A.; Albus, K.; Cremer, A. L.; Hanssen, R.; Lippert, R. N.; Cornely, O. A.; Small, D. M.; Brüning, J. C. et al.; Tittgemeyer, M.: Food intake recruits orosensory and post-ingestive dopaminergic circuits to affect eating desire in humans. Cell Metabolism 29 (3), pp. 695 - 706.e4 (2019)

Thanarajah, S. E.; Hoffstall, V.; Rigoux, L.; Hanssen, R.; Brüning, J. C.; Tittgemeyer, M.: The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Scientific Reports 9, 7222 (2019)

Turpin-Nolan, S. M.; Hammerschmidt, P.; Chen, W.; Jais, A.; Timper, K.; Awazawa, M.; Brodesser, S.; Brüning, J. C.: CerS1-derived C18:0 ceramide in skeletal muscle promotes obesity-induced insulin resistance. Cell Reports 26 (1), pp. 1 - 10.e7 (2019)

Wang, L.; De Solis, A. J.; Goffer, Y.; Birkenbach, K. E.; Engle, S. E.; Tanis, R.; Levenson, J. M.; Lie, X.; Rausch, R.; Purohit, M. et al.; Lee, J.-Y.; Tan, J.; De Rosa, M. C.; Doege, C. A.; Aaron, H. L.; Martins, G. J.; Brüning, J. C.; Egli, D.; Costa, R.; Berbari, N.; Leibel, R. L.; Stratigopoulos, G.: Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight 4, e123337 (2019)

Brandt, C.; Nolte, H.; Henschke, S.; Ruud, L. E.; Awazawa, M.; Morgan, D. A.; Gabel, P.; Sprenger, H.-G.; Hess, M. E.; Günther, S. et al.; Langer, T.; Rahmouni, K.; Fenselau, H.; Krüger, M.; Brüning, J. C.: Food perception primes hepatic ER homeostasis via melanocortin-dependent control of mTOR activation. Cell 175 (5), pp. 1321 - 1335.e.20 (2018)

Dafinger, C.; Rinschen, M. M.; Borgal, L.; Ehrenberg, C.; Basten, S. G.; Franke, M.; Hoehne, M.; Rauh, M.; Goebel, H.; Bloch, W. et al.; Wunderlich, F. T.; Peters, D. J.M.; Tasche, D.; Mishra, T.; Habbig, S.; Dötsch, J.; Müller, R.-U.; Brüning, J. C.; Persigehl, T.; Giles, R. H.; Benzing, T.; Schermer, B.; Liebau, M. C.: Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Experimental and Molecular Medicine 50, 75 (2018)

Dodd, G. T.; Michael, N. J.; Lee-Young, R. S.; Mangiafico, S. P.; Pryor, J. T.; Munder, A. C.; Simonds, S. E.; Brüning, J. C.; Zhang, Z.-Y.; Cowley, M. A. et al.; Andrikopoulos, S.; Horvath, T. L.; Spanswick, D.; Tiganis, T.: Insulin regulates POMC neuronal plasticity to control glucose metabolism. eLife 7, e38704 (2018)

Dodd, G. T.; Young, R. S.; Brüning, J. C.; Tiganis, T.: TCPTP regulates insulin signaling in AgRP neurons to coordinate glucose metabolism with feeding. Diabetes 67 (7), pp. 1246 - 1257 (2018)

Jiang, H.; Brüning, J. C.: Melanin-concentrating hormone-dependent control of feeding: when volume matters. Cell Metabolism 28 (1), pp. 7 - 8 (2018)

Löhr, H.; Hess, S.; Robalo de Azevedo Aleixo Pereira, M. M.; Reinoß, P.; Leibold, S.; Schenkel, C.; Wunderlich, C. M.; Kloppenburg, P.; Brüning, J. C.; Hammerschmidt, M.: Diet-induced growth is regulated via acquired Leptin resistance and engages a Pomc-somatostatin-growth hormone circuit. Cell Reports 23 (6), pp. 1728 - 1741 (2018)

Mittenbühler, M.; Sprenger, H.-G.; Gruber, S.; Wunderlich, C. M.; Kern, L.; Brüning, J. C.; Wunderlich, F. T.: Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma. Molecular Metabolism 17, pp. 122 - 133 (2018)

Quinones, M.; Al-Massadi, O.; Folgueira, C.; Bremser, S.; Gallego, R.; Torres-Leal, L.; Haddad-Tovolli, R.; Carcia-Caceres, C.; Hernandez-Bautista, R.; Lam, B. Y.H. et al.; Beiroa, D.; Sanchez-Rebordelo, E.; Senra, A.; Malagon, J. A.; Valeria, P.; Fondevila, M. F.; Ferno, J.; Malagon, M. M.; Contreras, R.; Pfluger, P.; Brüning, J. C.; Yeo, G.; Tschöp, M. H.; Dieguez, C.; Lopez, M.; Claret, M.; Kloppenburg, P.; Sabio, G.; Nogueiras, R.: p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nature Communications 9 (1), 3432 (2018)

Schüler, R.; Seebeck, N.; Osterhoff, M. A.; Witte, V.; Flöel, A.; Busjahn, A.; Jais, A.; Brüning, J. C.; Frahnow, T.; Kabisch, S. et al.; Pivovarova, O.; Hornemann, S.; Kruse, M.; Pfeiffer, A. F.H.: VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans. Molecular Metabolism 11 (May), pp. 129 - 136 (2018)

Timper, K.; Paeger, L.; Sanchez-Lasheras, C.; Varela, L.; Jais, A.; Nolte, H.; Vogt, M. C.; Hausen, A. C.; Heilinger, C.; Evers, N. et al.; Pospisilik, J. A.; Penninger, J. M.; Taylor, E. B.; Horvath, T. L.; Kloppenburg, P.; Brüning, J. C.: Mild impairment of mitochondrial OXPHOS promotes fatty acid utilization in POMC neurons and improves glucose homeostasis in obesity. Cell Reports 25 (2), pp. 383 - 397 (2018)