Talk by Dr. Wenfei Han, MPI for Biological Cybernetics, Tübingen

Gut-Brain Pathways and Parkinson’s pathology

  • Date: Sep 14, 2023
  • Time: 02:00 PM - 03:00 PM (Local Time Germany)
  • Location: MPI for Metabolism Research, Gleueler Strasse 50, 50931 Köln
  • Room: Seminar room 1
  • Host: Dr. Henning Fenselau
  • Contact: henning.fenselau@sf.mpg.de
Talk by Dr. Wenfei Han, MPI for Biological Cybernetics, Tübingen
Parkinson’s is a debilitating neurodegenerative disease affecting nearly 10 million people worldwide. The pathology appears to depend on the diffusion of abnormal aggregates of the endogenous α-synuclein protein across the nervous system. How the diffusion occurs remains controversial. Clinical evidence suggests that the gastrointestinal tract is a site of origin for α-synuclein, which then may spread to the brain. I will present studies in mice in which we tried to map the body-brain pathways via which the pathology may spread from the gut. I will also mention the potential role of gut immune cells in this process.
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