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Large-scale brain modes reorganize between infant sleep states and predict developmental outcome in preterms

15180 1536241871

Talk by Prof. Michael Breakspear, QIMR Berghofer Medical Research Institute, Brisbane, Australia

  • Date: Sep 17, 2018
  • Time: 14:00 - 15:00
  • Speaker: Prof. Michael Breakspear
  • Senior Scientist, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
  • Room: Seminar room 1
  • Host: Dr. Marc Tittgemeyer
  • Contact: marc.tittgemeyer@sf.mpg.de
Sleep architecture carries important information about brain health. Here we show that active compared to quiet sleep in infants heralds a marked change from long- to short-range functional connectivity across broad-frequency neural activity. This change in cortical connectivity is attenuated following preterm birth and pre-empts visual performance at two years. Biophysical modeling shows that active sleep is defined by reduced energy in a large-scale, uniform mode of spatiotemporal neural activity and increased energy in two non-uniform anteroposterior modes. This distinct energy redistribution leads to the emergence of more complex connectivity patterns in active sleep compared to quiet sleep. Preterm-born infants show an attenuation in this sleep-related reorganization of connectivity that carries novel prognostic information.
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