Publications of Eckhard Mandelkow
All genres
Journal Article (32)
2016
Journal Article
11 (1), 96 (2016)
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model. Molecular Neurodegeneration
Journal Article
17 (1), pp. 5 - 21 (2016)
Tau in physiology and pathology. Nature Reviews Neuroscience 2015
Journal Article
12 (9), pp. 814 - 828 (2015)
Identification of small molecule inhibitors of tau aggregation by targeting monomeric tau as a potential therapeutic approach for tauopathies. Current Alzheimer Research
Journal Article
6, 7025 (2015)
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications 2014
Journal Article
289 (29), pp. 20318 - 20332 (2014)
Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. Journal of Biological Chemistry
Journal Article
37 (12), pp. 721 - 732 (2014)
Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease. Trends in Neurosciences 2013
Journal Article
56 (11), pp. 4135 - 4155 (2013)
Progress and developments in tau aggregation inhibitors for Alzheimer disease. Journal of Medicinal Chemistry
Journal Article
34 (5), pp. 1343 - 1354 (2013)
Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of Aging
Journal Article
110 (4), pp. E313 - E321 (2013)
The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proceedings of the National Academy of Sciences of the United States of America 2012
Journal Article
21 (6), pp. 3587 - 3603 (2012)
Inhibition of Tau aggregation in a novel caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Human Molecular Genetics
Journal Article
51 (12), pp. 2539 - 2550 (2012)
Interaction of Tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry
Journal Article
40 (4), pp. 644 - 652 (2012)
Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society Transactions