BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/45047/1747887
DTSTART:20260326T130000Z
DTEND:20260326T140000Z
CLASS:PUBLIC
CREATED:20260310T163500Z
DESCRIPTION:The passage of food through the alimentary canal generates a se
ries of feedback signals that are sensed by the brain and used to control
behavior. Many of these signals converge on the caudal brainstem\, which c
ontains the key neural circuits that drive meal termination.I will describ
e our work investigating the dynamics and function of these circuits durin
g ingestion. A central theme is that these circuits integrate layers of si
gnals from the mouth and gut\, both during ingestion and over longer times
cales through learning.\nSpeaker: Professor Zachary Knight\, PhD
LAST-MODIFIED:20260310T163500Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY:Control of ingestion by the caudal brainstem: Talk by Prof. Zachary
Knight\, University of California\, San Francisco\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/45047/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/44967/1747887
DTSTART:20260306T120000Z
DTEND:20260306T130000Z
CLASS:PUBLIC
CREATED:20260302T163208Z
DESCRIPTION:A balanced intake of nutrients is a key determinant of health\,
wellbeing\, and aging. To maintain homeostasis\, animals adapt their fora
ging strategies\, physiology\, and metabolism to meet immediate and future
demands. We aim to understand how animals decide what to eat and how thei
r metabolism aligns with physiological needs\, focusing on the interplay b
etween brain-body interactions\, metabolic processes\, and the microbiome\
, a key player in shaping these adaptations. Our research uses Drosophi
la melanogaster as a model to investigate nutritional decision-making
at the interface of behavior\, metabolism\, microbiome\, and physiology. B
y leveraging tools such as automated behavioral analyses\, metabolomics\,
connectomics\, neuronal activity imaging\, and precise nutritional and mic
robial manipulations\, we explore how internal states and environmental fa
ctors influence dietary choices and metabolic responses. This integrative
approach allows us to reveal how internal states and environmental context
s shape dietary decisions. Ultimately\, our goal is to build a unified fra
mework for understanding the principles of nutrient regulation\, offering
insights into metabolic resilience and fitness across species.\nSpeaker: C
arlos Ribeiro\, PhD
LAST-MODIFIED:20260310T162340Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:The Metabolic Mosaic: Illuminating the Interplay of Diet\, Microbi
ome\, Brain and Metabolism: Talk by Carlos Ribeiro\, PhD\, Champalimaud Ce
ntre for the Unknown\, Lisbon
URL;VALUE=URI:https://www.sf.mpg.de/events/44967/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/44127/1747887
DTSTART:20251216T110000Z
DTEND:20251216T120000Z
CLASS:PUBLIC
CREATED:20251208T153419Z
DESCRIPTION:Speaker: Aleksandra Trifunovic
LAST-MODIFIED:20251208T153419Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Where Heme Biosynthesis Meets Fate: In
flammation or Cell Death"
URL;VALUE=URI:https://www.sf.mpg.de/events/44127/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/44128/1747887
DTSTART:20251209T110000Z
DTEND:20251209T120000Z
CLASS:PUBLIC
CREATED:20251208T153427Z
DESCRIPTION:Speaker: Robert Hänsel-Hertsch
LAST-MODIFIED:20251208T153427Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "DNA G-quadruplexes in the human genome
: detection\, functions and therapeutic potential for cancer and aging"
URL;VALUE=URI:https://www.sf.mpg.de/events/44128/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/43747/1747887
DTSTART:20251114T090000Z
DTEND:20251114T100000Z
CLASS:PUBLIC
CREATED:20251105T135559Z
DESCRIPTION:Brain circuits that sense energy do far more than drive appe
tite. This talk explores how hypothalamic and brainstem networks orchestra
te whole-body metabolism\, managing a critical trade-off between immune re
adiness and energy conservation. This highlights an emerging framework of
how the brain dynamically matches whole-body physiology to its perceived e
nergy status and prioritizes tissue maintenance under changing nutritional
states.\nSpeaker: Giuseppe D'Agostino\, PhD
LAST-MODIFIED:20251105T135815Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Neuronal Circuits Controlling Energy Metabolism Beyond Appetite Reg
ulation: Talk by Giuseppe D'Agostino\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/43747/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/43111/1747887
DTSTART:20251014T100000Z
DTEND:20251014T110000Z
CLASS:PUBLIC
CREATED:20250922T092100Z
DESCRIPTION:Speaker: Jan Riemer
LAST-MODIFIED:20250922T092100Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Organizing a compartment by redox - th
e mitochondrial intermembrane space"
URL;VALUE=URI:https://www.sf.mpg.de/events/43111/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/43110/1747887
DTSTART:20251007T100000Z
DTEND:20251007T110000Z
CLASS:PUBLIC
CREATED:20250922T092043Z
DESCRIPTION:Speaker: Miguel A. Alejandre Álcazar
LAST-MODIFIED:20250922T092043Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Setting the Clock: How Intergeneration
al and Early Life Injury Shapes Lung Aging and Disease"
URL;VALUE=URI:https://www.sf.mpg.de/events/43110/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/42937/1747887
DTSTART:20250926T120000Z
DTEND:20250926T130000Z
CLASS:PUBLIC
CREATED:20250908T155453Z
DESCRIPTION:Metabolic diseases such as obesity and type-2 diabetes (T2D) ar
e among the most pressing health challenges of our time. Affecting over on
e-third of the world’s population\, they are projected to become the lea
ding cause of mortality by 2030. Discovering effective treatments is a glo
bal health priority.While long regarded as disorders of peripheral organs\
, mounting evidence reveals that the brain plays a central role in their d
evelopment and progression. This seminar will explore how neural circuits
regulate energy balance\, glucose homeostasis\, and insulin sensitivity\,
highlighting the dynamic two-way communication between the brain and perip
heral tissues.Drawing on recent discoveries from AProf Dodd’s laboratory
\, we will examine how specific brain pathways act as potential therapeuti
c targets. By understanding and harnessing these mechanisms\, new opportun
ities emerge to design treatments that more effectively combat obesity and
T2D.\nSpeaker: Garron Dodd\, PhD
LAST-MODIFIED:20250908T155453Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar room 1
ORGANIZER;CN=Dr. Marie Holm Solheiim:mailto:marie.solheim@sf.mpg.de
SUMMARY:Unlocking Brain Pathways to Treat Metabolic Disease: Talk by Garron
Dodd\, PhD\, University of Melbourne\, Australia
URL;VALUE=URI:https://www.sf.mpg.de/events/42937/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/43109/1747887
DTSTART:20250923T100000Z
DTEND:20250923T110000Z
CLASS:PUBLIC
CREATED:20250922T092032Z
DESCRIPTION:Speaker: Marc Tittgemeyer\, Max Planck Institute for Metaboli
sm Research
LAST-MODIFIED:20250922T092032Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Metabolic regulation of motivational d
rive" - CANCELLED
URL;VALUE=URI:https://www.sf.mpg.de/events/43109/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/42777/1747887
DTSTART:20250910T120000Z
DTEND:20250910T130000Z
CLASS:PUBLIC
CREATED:20250820T122414Z
DESCRIPTION:Across mammalian species\, new mothers undergo behavioural chan
ges to nurture their offspring and meet the caloric demands of milk produc
tion. Although many neural circuits underlying feeding and parenting behav
iours are well characterized\, it is unclear how these different circuits
interact and adapt during lactation. Here we performed transcriptomic prof
iling of the arcuate nucleus (ARC) and the medial preoptic area (MPOA) of
the mouse hypothalamus in response to lactation and hunger. Furthermore\,
we showed that heightened appetite in lactating mice was accompanied by in
creased activity of hunger-promoting agouti-related peptide (AgRP) neurons
in the ARC (ARCAgRP neurons). To assess the strength of hunger
versus maternal drives\, we designed a conflict assay in which female mic
e chose between a food source or pups and nesting material. Although food-
deprived lactating mothers prioritized parenting over feeding\, hunger red
uced the duration and disrupted the sequences of parenting behaviours in b
oth lactating and virgin females. We found that ARCAgRP neurons
inhibit bombesin receptor subtype 3 (BRS3) neurons in the MPOA (MPOA
BRS3 neurons)\, which become more active postpartum and govern paren
ting and satiety. Activation of this ARCAgRP-to-MPOABRS3 circuit shifted behaviours from parenting to food-seeking. Thus\, hyp
othalamic networks are modulated by physiological states and work antagoni
stically during the prioritization of competing motivated behaviours.\nSpe
aker: Dr. Michael Krashes
LAST-MODIFIED:20250820T122414Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:A hypothalamic circuit that modulates feeding and parenting behavi
ours: Talk by Michael J. Krashes\, National Institutes of Health\, Bethesd
a\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/42777/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/42769/1747887
DTSTART:20250901T130000Z
DTEND:20250901T140000Z
CLASS:PUBLIC
CREATED:20250819T162257Z
DESCRIPTION:Most organisms exhibit circadian rhythms—approximately 24-hou
r cycles of physiological fluctuations—governed by a “central clock.
” In mammals\, this central clock resides in the hypothalamic suprachias
matic nucleus (SCN). The SCN functions as an autonomous oscillator\, gener
ating near-24-hour rhythms through cellular transcription–translation fe
edback loops (TTFLs) and neuronal connections within the SCN. However\, th
e neural outputs of the SCN and their role in driving circadian rhythms ha
ve long remained poorly understood. One of the many regions receiving proj
ections from the SCN is the dorsomedial hypothalamic nucleus (DMH)\, which
is critical for homeostatic regulation of body temperature\, feeding\, an
d metabolism. Our group investigates the role of the neural circuitry conn
ecting the SCN and DMH in the regulation of behavioral and metabolic rhyth
ms\, and I will be presenting our latest findings on this topic.\nSpeaker:
Ruth Li\, PhD
LAST-MODIFIED:20250819T162302Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Shuntaro Izawa:mailto:shuntaro.izawa@sf.mpg.de
SUMMARY:The SCN-DMH neural pathway regulates circadian output from the cent
ral clock: Talk by Ruth Li\, PhD\, University of Tsukuba\, Japan
URL;VALUE=URI:https://www.sf.mpg.de/events/42769/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41948/1747887
DTSTART:20250624T100000Z
DTEND:20250624T110000Z
CLASS:PUBLIC
CREATED:20250526T081350Z
DESCRIPTION:Speaker: Sabine Eming\, FM | Department of Dermatology & FMNS |
Institute of Zoology (UoC) & CMMC
LAST-MODIFIED:20250526T081350Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Exploring how immunity controls tissue
regeneration - the skin as a model"
URL;VALUE=URI:https://www.sf.mpg.de/events/41948/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41947/1747887
DTSTART:20250617T100000Z
DTEND:20250617T110000Z
CLASS:PUBLIC
CREATED:20250526T081340Z
DESCRIPTION:Speaker: Christian Frezza\, FM | Metabolomics in Aging (CECAD)
LAST-MODIFIED:20250526T081340Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "The role of mitochondria in cancer: fr
om initiation to metastasis"
URL;VALUE=URI:https://www.sf.mpg.de/events/41947/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/42045/1747887
DTSTART:20250610T140000Z
DTEND:20250610T150000Z
CLASS:PUBLIC
CREATED:20250603T140938Z
DESCRIPTION:Sleep is vital for brain function\, but how the brain senses th
e need for sleep—known as "sleep pressure"—is still not fully understo
od. In our recent studies\, we explored the idea that the strength of conn
ections between neurons may play a key role in this process. Combining mat
hematical modeling with experiments in cultured neurons\, we found that st
ronger synaptic connections promote brain activity patterns associated wit
h deep sleep. We also used a molecular tool to selectively boost synaptic
strength in the prefrontal cortex of mice\, which led to longer and deeper
sleep. In this talk\, I will present our latest findings suggesting that
synaptic strength may serve as an internal signal for sleep need—and dis
cuss what this means for how the brain regulates rest and recovery.\nSpeak
er: Shi Shoi\, PhD
LAST-MODIFIED:20250603T140958Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Shuntaro Izawa:mailto:shuntaro.izawa@sf.mpg.de
SUMMARY:Does Synaptic Strength Encode Sleep Need?: Talk by Dr. Shi Shoi\, U
niversity of Tsukuba\, Japan
URL;VALUE=URI:https://www.sf.mpg.de/events/42045/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41949/1747887
DTSTART:20250610T100000Z
DTEND:20250610T110000Z
CLASS:PUBLIC
CREATED:20250526T081401Z
DESCRIPTION:Speaker: Silvia von Karsted\, FM | Department of Translational
Genomics (UHC) & CMMC
LAST-MODIFIED:20250526T081401Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Intricate ways how small cell lung can
cer (SCLC) rewires regulated cell death pathways"
URL;VALUE=URI:https://www.sf.mpg.de/events/41949/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41687/1747887
DTSTART:20250527T100000Z
DTEND:20250527T110000Z
CLASS:PUBLIC
CREATED:20250428T101749Z
DESCRIPTION:Speaker: Christian Pallasch\, Department I of Internal Medicine
\, Translational Research for Infectious Diseases and Oncology (TRIO)
LAST-MODIFIED:20250428T101749Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:CANCELLED! Biomedical Seminars Cologne "Therapy responses in B cell
Lymphomas are determined by regulation of Macrophages in the Lymphoma Mic
roenvironment"
URL;VALUE=URI:https://www.sf.mpg.de/events/41687/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41842/1747887
DTSTART:20250521T160000Z
DTEND:20250521T173000Z
CLASS:PUBLIC
CREATED:20250514T064410Z
DESCRIPTION:Immer mehr Menschen leiden unter Übergewicht. Insbesondere sta
rkes Übergewicht – auch Adipositas genannt – gilt als Risikofaktor f
ür viele Erkrankungen.Im Gespräch erfahren Teilnehmer*innen\, was bei Ü
bergewicht im Gehirn passiert und warum eine langfristige Gewichtsabnahme
oft so schwierig ist. Die Veranstaltung informiert über Möglichkeiten de
r Therapie\, Prävention und Selbsthilfe.Referentinnen:Dr. med. Ruth Hanß
en (Oberärztin für Innere Medizin\, Endokrinologie und Diabetologie der
Uniklinik Köln\, Leiterin AG Translationale Stoffwechselforschung)Gabriel
e Konopka (Adipositas Selbsthilfe Köln-Merheim)\nSpeaker: Dr. med. Ruth H
anßen\, Gabriele Konopka
LAST-MODIFIED:20250514T064538Z
LOCATION: Gesundheitsamt der Stadt Köln Neumarkt 15-21 50667 K
öln - Altstadt/Süd
ORGANIZER;CN=Volkshochschule Köln:mailto:
SUMMARY:Stoffwechsel und Übergewicht – Macht uns unser Gehirn dick?
URL;VALUE=URI:https://www.sf.mpg.de/events/41842/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41688/1747887
DTSTART:20250520T100000Z
DTEND:20250520T110000Z
CLASS:PUBLIC
CREATED:20250428T101757Z
DESCRIPTION:Speaker: Valentina Piano\, FM | Center for Molecular Medicine C
ologne (CMMC)
LAST-MODIFIED:20250428T101757Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Mechanisms regulating mitochondrial dy
namics during cell division"
URL;VALUE=URI:https://www.sf.mpg.de/events/41688/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40513/1747887
DTSTART:20250517T090000Z
DTEND:20250517T140000Z
CLASS:PUBLIC
CREATED:20250122T113242Z
DESCRIPTION:
LAST-MODIFIED:20250122T113242Z
LOCATION:MPI für Stoffwechselforschung\, MPI für Biologie des Alterns & C
ECAD Exzellenzcluster
SUMMARY:Tag der offenen Tür "Stoffwechsel und Altern: Forschung für ein l
anges und gesundes Leben"
URL;VALUE=URI:https://www.sf.mpg.de/events/40513/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41357/1747887
DTSTART:20250429T100000Z
DTEND:20250429T110000Z
CLASS:PUBLIC
CREATED:20250324T085931Z
DESCRIPTION:Speaker: Marc Tittgemeyer\, Max Planck Institute for Metabolism
Research
LAST-MODIFIED:20250324T085931Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Motivated Behaviour under Metabolic Co
ntrol" CANCELLED!
URL;VALUE=URI:https://www.sf.mpg.de/events/41357/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41356/1747887
DTSTART:20250415T100000Z
DTEND:20250415T110000Z
CLASS:PUBLIC
CREATED:20250324T085909Z
DESCRIPTION:Speaker: Holger Winkels\, Center for Molecular Medicine Cologne
LAST-MODIFIED:20250324T085909Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Olfactory receptor 2 as central mediat
or of cardiovascular disease"
URL;VALUE=URI:https://www.sf.mpg.de/events/41356/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41119/1747887
DTSTART:20250325T110000Z
DTEND:20250325T120000Z
CLASS:PUBLIC
CREATED:20250305T094753Z
DESCRIPTION:Speaker: Carien Niessen\, FM | Department Cell Biology of the S
kin (UHC) & CMMC
LAST-MODIFIED:20250305T094753Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Mechanochemical signaling regulating e
pithelial barrier homeostasis in health and disease"
URL;VALUE=URI:https://www.sf.mpg.de/events/41119/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41118/1747887
DTSTART:20250318T110000Z
DTEND:20250318T120000Z
CLASS:PUBLIC
CREATED:20250305T094740Z
DESCRIPTION:Speaker: Gabrielle Zaffagnini\, FMNS | Institute for Genetics
(UoC)
LAST-MODIFIED:20250305T094740Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Regulation of protein degradation in m
ammalian oocytes"
URL;VALUE=URI:https://www.sf.mpg.de/events/41118/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/41117/1747887
DTSTART:20250311T110000Z
DTEND:20250311T120000Z
CLASS:PUBLIC
CREATED:20250305T094730Z
DESCRIPTION:Speaker: Sophie Steculorum\, Max Planck Institute for Metabolis
m Research
LAST-MODIFIED:20250305T094730Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Sensory Control of Feeding Behavior an
d Metabolism"
URL;VALUE=URI:https://www.sf.mpg.de/events/41117/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40568/1747887
DTSTART:20250225T110000Z
DTEND:20250225T120000Z
CLASS:PUBLIC
CREATED:20250127T084623Z
DESCRIPTION:Speaker: Dirk Isbrand\, Institute for Molecular and Behavioral
Neuroscience
LAST-MODIFIED:20250127T084623Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Precision Medicines for Neuronal Chann
elopathies: Linking Channel Dysfunction\, Network Alterations and Treatmen
t Response"
URL;VALUE=URI:https://www.sf.mpg.de/events/40568/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40569/1747887
DTSTART:20250218T110000Z
DTEND:20250218T120000Z
CLASS:PUBLIC
CREATED:20250127T084708Z
DESCRIPTION:Speaker: Manolis Pasparakis\, FMNS\, Institute for Genetics (U
oC)
LAST-MODIFIED:20250127T084708Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Regulation and sensing of Z-RNA in cel
l death and interferon responses"
URL;VALUE=URI:https://www.sf.mpg.de/events/40569/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40364/1747887
DTSTART:20250213T130000Z
DTEND:20250213T140000Z
CLASS:PUBLIC
CREATED:20250109T151115Z
DESCRIPTION:Speaker: Christoffer Clemmensen\, PhD
LAST-MODIFIED:20250109T151154Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:Emerging pathways: Body weight biology and weight loss pharmacother
apy : Talk by Prof. Christoffer Clemmensen\, University of Copenhagen\, De
nmark
URL;VALUE=URI:https://www.sf.mpg.de/events/40364/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40570/1747887
DTSTART:20250211T110000Z
DTEND:20250211T120000Z
CLASS:PUBLIC
CREATED:20250127T084723Z
DESCRIPTION:Speaker: Ute Deichmann\, Institute of Genetics\, Ben-Gurion Uni
versity of the Negev
LAST-MODIFIED:20250127T084723Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Self-organization and genomic causalit
y in models of morphogenesis\, past and present"
URL;VALUE=URI:https://www.sf.mpg.de/events/40570/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40571/1747887
DTSTART:20250204T110000Z
DTEND:20250204T120000Z
CLASS:PUBLIC
CREATED:20250127T084732Z
DESCRIPTION:Speaker: Anne Schaefer (MPI for Biology of Ageing)
LAST-MODIFIED:20250127T084732Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Alzheimer disease reveals regulatory m
icroglia potential"
URL;VALUE=URI:https://www.sf.mpg.de/events/40571/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40514/1747887
DTSTART:20250128T110000Z
DTEND:20250128T120000Z
CLASS:PUBLIC
CREATED:20250122T113319Z
DESCRIPTION:Speaker: Stephanie Panier (MPI for Biology of Ageing)
LAST-MODIFIED:20250122T113319Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Beyond telomerase: How Alternative Len
gthening of Telomeres drives cancer cell immortality"
URL;VALUE=URI:https://www.sf.mpg.de/events/40514/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39411/1747887
DTSTART;VALUE=DATE:20250123
DTEND;VALUE=DATE:20250124
CLASS:PUBLIC
CREATED:20241002T060935Z
DESCRIPTION:Joined Science Day of MPI for Biology of Ageing and MPI for Met
abolism Research.
LAST-MODIFIED:20241002T060935Z
LOCATION:Max-Planck-Institut für Biologie des Alterns
SUMMARY:MetabAge Science Day
URL;VALUE=URI:https://www.sf.mpg.de/events/39411/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40515/1747887
DTSTART:20250121T110000Z
DTEND:20250121T120000Z
CLASS:PUBLIC
CREATED:20250122T113346Z
DESCRIPTION:Speaker: Gianmaria Liccardi (Center for Biochemistry)
LAST-MODIFIED:20250122T113346Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "STING role in different cell death mod
alities during development and disease"
URL;VALUE=URI:https://www.sf.mpg.de/events/40515/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40516/1747887
DTSTART:20250114T110000Z
DTEND:20250114T120000Z
CLASS:PUBLIC
CREATED:20250122T113401Z
DESCRIPTION:Speaker: Marius Lemberg (Center for Biochemistry)
LAST-MODIFIED:20250122T113401Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Maintenance of organelle protein homeo
stasis by membrane proteases and pseudoproteases"
URL;VALUE=URI:https://www.sf.mpg.de/events/40516/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39975/1747887
DTSTART:20241217T110000Z
DTEND:20241217T120000Z
CLASS:PUBLIC
CREATED:20241118T155752Z
DESCRIPTION:Speaker: Christian Frezza\, FM | Metabolomics in Aging (CECAD)
LAST-MODIFIED:20241118T155752Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "The role of mitochondria in cancer: fr
om initiation to metastases"
URL;VALUE=URI:https://www.sf.mpg.de/events/39975/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39976/1747887
DTSTART:20241210T110000Z
DTEND:20241210T120000Z
CLASS:PUBLIC
CREATED:20241118T155801Z
DESCRIPTION:Speaker: Hamid Kashkar\, FM | Institute for Molecular Immunolog
y (UHC)
LAST-MODIFIED:20241118T155801Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "The Good\, The Bad\, and The Ugly miss
ions of cel death in our bodies"
URL;VALUE=URI:https://www.sf.mpg.de/events/39976/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/40058/1747887
DTSTART:20241203T130000Z
DTEND:20241203T140000Z
CLASS:PUBLIC
CREATED:20241127T101400Z
DESCRIPTION:Change notice: Cancelled\nDespite significant progress\, the ne
uronal mechanisms that regulate body weight remain incompletely understood
. In this presentation\, I will highlight our past and ongoing efforts to
leverage human genetics data alongside rodent single-cell analyses to unco
ver molecular processes in the mediobasal hypothalamus and hindbrain that
regulate energy homeostasis.\nSpeaker: Prof. Tune Pers\, PhD
LAST-MODIFIED:20241203T094104Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:corinna.bauder@sf.mpg.de
SUMMARY:Deciphering Obesity-Linked Brain Circuits with Genetic and Single-
Cell Strategies: Talk by Professor Tune Pers\, University of Copenhagen\,
Denmark
URL;VALUE=URI:https://www.sf.mpg.de/events/40058/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39977/1747887
DTSTART:20241203T110000Z
DTEND:20241203T120000Z
CLASS:PUBLIC
CREATED:20241118T155831Z
DESCRIPTION:Speaker: Günter Schwarz\, FMNS / Institute of Biochemistry
LAST-MODIFIED:20241118T155831Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Molybdenum biochemistry: From ultra-ra
re metabolic disorders to longevity and cardiovascular diseases"
URL;VALUE=URI:https://www.sf.mpg.de/events/39977/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39746/1747887
DTSTART:20241119T110000Z
DTEND:20241119T120000Z
CLASS:PUBLIC
CREATED:20241104T080715Z
DESCRIPTION:Speaker: Constantinos Demetriades
LAST-MODIFIED:20241104T080715Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Metabolic and Nutrient Signaling at th
e center of Everything"
URL;VALUE=URI:https://www.sf.mpg.de/events/39746/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39745/1747887
DTSTART:20241112T110000Z
DTEND:20241112T120000Z
CLASS:PUBLIC
CREATED:20241104T080646Z
DESCRIPTION:Speaker: Elisa Motori (FMNS / Institute of Biochemistry)
LAST-MODIFIED:20241104T080646Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "The never-ending quest for metabolic h
omeostasis in neurons through the lens of mitochondria"
URL;VALUE=URI:https://www.sf.mpg.de/events/39745/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39744/1747887
DTSTART:20241105T110000Z
DTEND:20241105T120000Z
CLASS:PUBLIC
CREATED:20241104T080630Z
DESCRIPTION:Speaker: Débora B. Trentini Schmidt (FM | CMMC)
LAST-MODIFIED:20241104T080630Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Lost in translation: principles of pro
tein degradation at the ribosome"
URL;VALUE=URI:https://www.sf.mpg.de/events/39744/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39685/1747887
DTSTART:20241104T140000Z
DTEND:20241104T150000Z
CLASS:PUBLIC
CREATED:20241023T150443Z
DESCRIPTION:The majority of human diseases involve complex interactions of
different cellular and organ systems. Traditional organ-centric pathophysi
ological models fail to capture these interactions. This talk outlines cir
cuits of organ crosstalk in the gastrointestinal tract with a focus on the
gut-liver-brain axis. Recently\, we identified the impact of glucocortico
ids on enteric glia and neurons and discovered the underlying mechanism th
at relays psychological stress to the exacerbation of gut inflammation.The
talk will highlight new data on the emerging field of neuro-immune intera
ctions and discuss potential implications for IBD.\nSpeaker: Prof. Dr. Dr.
Kai Markus Schneider
LAST-MODIFIED:20241023T150703Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Stressing the gut-brain axis : Talk by Prof. Kai Markus Schneider\,
MD\, PhD\, TU Dresden
URL;VALUE=URI:https://www.sf.mpg.de/events/39685/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39415/1747887
DTSTART:20241029T110000Z
DTEND:20241029T120000Z
CLASS:PUBLIC
CREATED:20241002T061123Z
DESCRIPTION:Speaker: Alessandro Annibaldi (CMMC\, Cell death and inflammati
on)
LAST-MODIFIED:20241002T061123Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Cell death plasticity in intestine and
skin"
URL;VALUE=URI:https://www.sf.mpg.de/events/39415/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39414/1747887
DTSTART:20241022T100000Z
DTEND:20241022T110000Z
CLASS:PUBLIC
CREATED:20241002T061107Z
DESCRIPTION:Speaker: Mauro Corrado
LAST-MODIFIED:20241002T061107Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Metabolic Drivers of Infections and In
flammation"
URL;VALUE=URI:https://www.sf.mpg.de/events/39414/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39413/1747887
DTSTART:20241015T100000Z
DTEND:20241015T110000Z
CLASS:PUBLIC
CREATED:20241002T061054Z
DESCRIPTION:Speaker: Kathrin Ulrich (Institute of Biochemistry\, Cellular B
iochemistry)
LAST-MODIFIED:20241002T061054Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne “Redox-regulated chaperones – From
a tightly controlled thiol switch to proteostasis regulation”
URL;VALUE=URI:https://www.sf.mpg.de/events/39413/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39437/1747887
DTSTART:20241010T130000Z
DTEND:20241010T140000Z
CLASS:PUBLIC
CREATED:20241007T113841Z
DESCRIPTION:Amanda is a Postdoc in the labs of Steve Gygi and Bruce Spiegel
man and an expert in PISA and Cysteine Proteomics.\nSpeaker: Amanda Smythe
rs\, Harvard Medical School\, USA
LAST-MODIFIED:20241007T113841Z
LOCATION:Max-Planck-Institut für Biologie des Alterns\, Room: Auditorium
ORGANIZER;CN=Hans-Goerg Sprenger:mailto:
SUMMARY:From Tardigrades to Cancer Treatment: Creative Implementation of Pr
oteomics in Biological Discovery.
URL;VALUE=URI:https://www.sf.mpg.de/events/39437/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39412/1747887
DTSTART:20241008T100000Z
DTEND:20241008T110000Z
CLASS:PUBLIC
CREATED:20241002T061021Z
DESCRIPTION:Speaker: Andreas Wodarz (Institut für Anatomie\, Molekulare Ze
llbiologie)
LAST-MODIFIED:20241002T061021Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne “Molecular control of actomyosin cont
ractility during morphogenesis in Drosophila”
URL;VALUE=URI:https://www.sf.mpg.de/events/39412/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39103/1747887
DTSTART:20240926T120000Z
DTEND:20240926T130000Z
CLASS:PUBLIC
CREATED:20240904T145915Z
DESCRIPTION:The insular cortex is a multisensory brain region which is invo
lved in many behaviors\, including pain\, addiction\, social behavior\, le
arning &\; memory\, and feeding/metabolism. To date\, the gene expressi
on patterns of the insular cortex have not been systematically studied\, b
ut it has generally been assumed to be similar to other cortical areas. Ho
wever\, our data indicates that the insular cortex may have some key trans
criptomic differences from other cortical areas\, and that these insula-sp
ecific genes may have important behavioral functions. To probe this\, we c
onducted single cell sequencing of the insular cortex and compared it to s
omatosensory cortex. We find that indeed the insular cortex has a distinct
transcriptomic makeup compared to somatosensory cortex. We then investiga
ted the function of two insula-specific genes in complex feeding behaviors
. Probing the function of these insula-specific cell-types reveals importa
nt insights into the functions of the insular cortex vis-a-vis complex mot
ivated behaviors\, in particular salience detection and internal state sen
sing.\nSpeaker: Sarah Stern\, PhD
LAST-MODIFIED:20240904T145915Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY:Coordination of flexible feeding behaviors by molecularly defined i
nsular cortex populations : Talk by Sarah A. Stern\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/39103/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38980/1747887
DTSTART:20240919T120000Z
DTEND:20240919T130000Z
CLASS:PUBLIC
CREATED:20240823T125521Z
DESCRIPTION:It is clear that the cause of obesity is a result of eating mor
e than you burn. What is more complex to answer is why some people eat mor
e than others? Differences in our genetic make-up mean some of us are\, fo
r a myriad of different reasons\, driven to eat more than others. We now k
now that the genetics of body-weight\, on which obesity sits on one end of
the spectrum\, is in actuality the genetics of how the brain regulates ap
petite. In this talk\, I will discuss the use of different studies\, rangi
ng from large population based cohorts\, to smaller consanguineous groups
of individuals with extreme phenotypes\, coupled with ‘omics technologie
s\, to identify novel genes linked to obesity.\nSpeaker: Prof. Giles Yeo\,
PhD
LAST-MODIFIED:20240823T125521Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Corinna Bauder:mailto:corinna.bauder@sf.mpg.de
SUMMARY:The use of genetics to identify novel regulators of body shape and
size: Talk by Prof. Giles Yeo\, University of Cambridge
URL;VALUE=URI:https://www.sf.mpg.de/events/38980/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38822/1747887
DTSTART:20240919T110000Z
DTEND:20240919T120000Z
CLASS:PUBLIC
CREATED:20240807T144800Z
DESCRIPTION:Speaker: Miranda Ethel Orr
LAST-MODIFIED:20240807T144800Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Christina Ising (CECAD):mailto:
SUMMARY:Cologne Seminars on Ageing "Identifying\, Profiling and Therapeutic
ally Clearing Senescent Cells in Alzheimer’s Disease"
URL;VALUE=URI:https://www.sf.mpg.de/events/38822/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/39016/1747887
DTSTART:20240917T120000Z
DTEND:20240917T130000Z
CLASS:PUBLIC
CREATED:20240827T161925Z
DESCRIPTION:Midbrain dopamine (mDA) neurons are required for the formation
of reward-associated memories\, a vital mechanism allowing animals to adap
t to their environment. On the flipside\, dopaminergic dysfunction caused
by repeated exposure to strong reinforcers such as drugs of abuse or hyper
palatable foods can potentially trigger addiction and compulsive\, ‘bing
e’-style eating behaviors\, respectively. Intriguingly\, humans as well
as other animals display striking inter-individual differences in their vu
lnerability to develop such maladaptive behaviors\, which can even be obse
rved despite identical genetics and environment. Thus\, we here sought out
to explore the role of epigenetic modifications as potential drivers of s
tochastic variation in the susceptibility to develop binge-eating behavior
. To accomplish this\, we first performed fluorescence-assisted nuclei sor
ting (FANS) specifically of mDA neurons from control mice versus mice trai
ned to binge-feed on a hyperpalatable\, high-fat diet. When analyzing the
DNA methylation landscape of this purified cell type by means of the Infin
ium Mouse Methylation BeadChip (Mm285)\, we found that binge-feeding induc
es a dramatic reorganization of the mDA methylome (2\,674 DMR with increas
ed methylation versus 9\,799 DMR with decreased methylation\; p-value 0.05
and effect size 0.1). The marked loss of methyl marks across multiple gen
omic regions suggests a prominent role of demethylating enzymes such as Te
n-Eleven Translocation 1 (TET-1) dioxygenase\, which we interestingly foun
d to be highly enriched in mDA neurons. Consistently\, Tet1 haploin
sufficient mice (Tet1 +/-) exhibited marked differences
in motivated\, reward-related behaviors including reduced sucrose preferen
ce and attenuated binge-feeding. Notably\, bistable segregation into eithe
r binge-prone versus binge-resistant animals was significantly amplified i
n Tet1+/- mice hinting at a potential role in the stocha
sticity of behavioral variation towards calorie rewards. To reverse alread
y established binge-feeding phenotypes\, we started leveraging virus-based
approaches to rewire the mDA methylome in a locus-specific\, temporally c
ontrolled and TET1-mediated fashion in-vivo. In sum\, we provide ev
idence for TET1-mediated DNA demethylation in mDA neurons as an important
non-genetic\, non-environmental regulator determining flexibility in motiv
ated behaviors and susceptibility to binge-eating disorders.\nSpeaker: Tim
Gruber\, PhD
LAST-MODIFIED:20240827T161925Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Heiko Backes:mailto:heiko.backes@sf.mpg.de
SUMMARY:Food reward thresholds in binge-eating disorder vulnerability are n
euro-epigenetically determined by TET-1 dosage.: Talk by Dr. Tim Gruber\,
Van Andel Institute\, Grand Rapids\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/39016/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38850/1747887
DTSTART:20240910T100000Z
DTEND:20240910T110000Z
CLASS:PUBLIC
CREATED:20240813T072425Z
DESCRIPTION:Speaker: Mafalda Escobar-Henriquez\, CECAD
LAST-MODIFIED:20240813T072425Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Ubiquitin Precursor Controls Mitochond
rial and Cellular Stress Responses"
URL;VALUE=URI:https://www.sf.mpg.de/events/38850/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38851/1747887
DTSTART:20240820T100000Z
DTEND:20240820T110000Z
CLASS:PUBLIC
CREATED:20240813T072443Z
DESCRIPTION:Speaker: Thomas Langmann\, CMMC
LAST-MODIFIED:20240813T072443Z
LOCATION:MPI for Biology of Ageing\, Room: Auditorium
ORGANIZER;CN=Biomedical Seminars Cologne:mailto:
SUMMARY:Biomedical Seminars Cologne "Immunomodulation for Treating Blinding
Diseases"
URL;VALUE=URI:https://www.sf.mpg.de/events/38851/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38393/1747887
DTSTART:20240626T110000Z
CLASS:PUBLIC
CREATED:20240612T161915Z
DESCRIPTION:Speakers: Prof. Lisa R. Beutler\, Prof. J. Nicholas Betley
LAST-MODIFIED:20240612T161915Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
SUMMARY:1. Dissecting obesity-induced dysfunction of gut-brain circuits 2.
Adaptive control of food intake: Prof. Lisa Beutler\, Northwestern Univers
ity and Prof. Nicholas Betley\, University of Pennsylvania\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/38393/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/38347/1747887
DTSTART:20240624T123000Z
DTEND:20240624T140000Z
CLASS:PUBLIC
CREATED:20240607T142314Z
DESCRIPTION:Speaker: Prof. Takeshi Sakurai and Dr. Shingo Soya
LAST-MODIFIED:20240607T142314Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN="Prof. Jens Brüning, Dr. Shuntaro Izawa":mailto:shuntaro.izaw
a@sf.mpg.de
SUMMARY:1. Artificial Induction of Sleeping States via Neural Circuit Modul
ation 2. Amygdala Neurons Differentiating Unfamiliar and Familiar Mice to
Establish Social Novelty Preferences: Tandem Talk by Prof. Takeshi Sakurai
and Dr. Shingo Soya\, University of Tsukuba\, Japan
URL;VALUE=URI:https://www.sf.mpg.de/events/38347/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/37634/1747887
DTSTART:20240508T143000Z
DTEND:20240508T153000Z
CLASS:PUBLIC
CREATED:20240425T160559Z
DESCRIPTION:In this presentation\, I will highlight our recent work on smal
l intestinal protein sensing and how the kidney and the brain work in para
llel to regulate feeding\, weight and glucose homeostasis. Our findings un
veil therapeutic targets in the small intestine\, kidney and / or the brai
n to lower weight and glucose levels in obesity and diabetes.\nSpeaker: To
ny Lam\, PhD
LAST-MODIFIED:20240425T160745Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:The metabolic impact of the small intestine\, kidney and the brain
: Talk by Professor Tony Lam\, University of Toronto\, Canada
URL;VALUE=URI:https://www.sf.mpg.de/events/37634/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/37580/1747887
DTSTART:20240507T120000Z
DTEND:20240507T130000Z
CLASS:PUBLIC
CREATED:20240418T160002Z
DESCRIPTION:The design and function of endocrine systems follows an intrins
ic logic that is not specific\, but widely present in physiology. In my ta
lk\, I discuss homeostatic circuit designs at the intersection of endocrin
ology and immunology. I highlight examples that align with this regulatory
principle and those that may not. I then address the potential connection
between homeostatic control and inflammation and touch upon how I have ap
plied this framework to one of my projects on cancer. I summarize my more
recent findings on pharmacological manipulation of neuroendocrine control
of leukocyte compartments that I approached from the same perspective\, fo
llowed by a discussion of my observations in a broader context. Finally\,
I provide insights into fields that I am currently thinking about and acti
vely pursuing\, which have naturally emerged as a consequence of my scient
ific trajectory. I close my talk with concluding remarks and potential fut
ure avenues for scientific discovery.\nSpeaker: Nikolai Jaschke MD\, PhD
LAST-MODIFIED:20240418T160010Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Control theory at the intersection of endocrinology and immunology
: Talk by Nikolai Jaschke\, MD\, PhD\, Yale School of Medicine\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/37580/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/37434/1747887
DTSTART:20240418T120000Z
DTEND:20240418T130000Z
CLASS:PUBLIC
CREATED:20240412T113444Z
DESCRIPTION:In this talk I will discuss a link between obesity\, diet\, and
brain health\, drawing on neuroimaging data from population-based cohorts
and interventional trials. Results indicate that a higher body mass index
and visceral fat correlate with accelerated brain aging\, while intervent
ional data suggest benefits from weight loss and plant-based diets on brai
n structure and function. In parallel\, I like to share exemplary challeng
es that call for open science and a more holistic approach to study gut-br
ain interactions. Overall\, previous work underlined the intertwined natur
e of nutrition\, metabolism and brain health\, advocating for targeted int
erventions as a means to enhance brain plasticity.\nSpeaker: Dr. Veronica
Witte
LAST-MODIFIED:20240412T113444Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Marc Tittgemeyer:mailto:tittgemeyer@sf.mpg.de
SUMMARY:Exploring the impact of obesity and diet on human brain structure a
nd function : Talk by PD Dr. Veronica Witte\, MPI for Human Cognitive and
Brain Sciences\, Leipzig
URL;VALUE=URI:https://www.sf.mpg.de/events/37434/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/37267/1747887
DTSTART:20240411T120000Z
DTEND:20240411T130000Z
CLASS:PUBLIC
CREATED:20240325T150823Z
DESCRIPTION:Prof. Dr. Cristina Garcia Caceres is a renowned Spanish neurosc
ientist known for her groundbreaking research in obesity and neuroendocrin
ology. She earned her Ph.D. in Madrid\, Spain\, and pursued academic inter
nships at Yale University\, USA\, and Göteborg University\, Sweden. Follo
wing her doctoral studies\, she conducted postdoctoral research at Helmhol
tz Munich and TUM in Germany. In 2015\, she established the Astrocyte-Neur
on Network Unit at the Institute for Diabetes and Obesity. Currently\, she
holds the position of W2 professor at LMU and serves as the Head of Resea
rch and Deputy Director at the Institute for Diabetes and Obesity at Helmh
oltz Munich. For over 16 years\, Prof. Dr. Garcia Caceres has focused on u
nderstanding how the hypothalamus controls energy balance\, particularly t
hrough astrocytes. Her research aims to uncover the cellular mechanisms un
derlying obesity and metabolic disorders. Her pioneering work\, awarded wi
th ERC Starting Grant\, has shown that the brain's control of energy and g
lucose metabolism involves astrocytes. By exploring the interactions betwe
en neurons\, astroglia\, and blood vessels\, she seeks insights to inform
strategies for obesity prevention and treatment\, including associated con
ditions like hypertension. Additionally\, her recent research extends to u
nderstanding how the brain integrates peripheral endocrine cues into hypot
halamic circuits\, critical for metabolic adaptation in diet-induced obesi
ty. Overall\, her discoveries challenge traditional obesity treatment mode
ls and underscore the importance of considering sex as a biological variab
le in addressing this health issue.\nSpeaker: Cristina García-Cáceres\,
Prof. Dr.
LAST-MODIFIED:20240325T150823Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:Hypothalamic Astrocytes in Feeding Time Regulation : Talk by Prof
. Dr. Cristina García-Cáceres
URL;VALUE=URI:https://www.sf.mpg.de/events/37267/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/35357/1747887
DTSTART:20230914T120000Z
DTEND:20230914T130000Z
CLASS:PUBLIC
CREATED:20230906T170522Z
DESCRIPTION:Parkinson’s is a debilitating neurodegenerative disease affec
ting nearly 10 million people worldwide. The pathology appears to depend o
n the diffusion of abnormal aggregates of the endogenous α-synuclein prot
ein across the nervous system. How the diffusion occurs remains controvers
ial. Clinical evidence suggests that the gastrointestinal tract is a site
of origin for α-synuclein\, which then may spread to the brain. I will pr
esent studies in mice in which we tried to map the body-brain pathways via
which the pathology may spread from the gut. I will also mention the pote
ntial role of gut immune cells in this process.
LAST-MODIFIED:20230906T170847Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:Gut-Brain Pathways and Parkinson’s pathology : Talk by Dr. Wenfei
Han\, MPI for Biological Cybernetics\, Tübingen
URL;VALUE=URI:https://www.sf.mpg.de/events/35357/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/33800/1747887
DTSTART:20230327T123000Z
DTEND:20230327T133000Z
CLASS:PUBLIC
CREATED:20230307T132705Z
DESCRIPTION:A variety of environmental stressors\, such as temperature (hot
and cold)\, infection\, natural enemies\, and starvation\, can threaten l
ife. To survive environmental stresses\, mammals exert autonomic and behav
ioral responses as fundamental functions mediated by the CNS. Remarkable p
rogress has recently been made in understanding the central circuit mechan
isms of physiological responses to such stressors. A “trunk” neural pa
thway from the dorsomedial hypothalamus (DMH) to the rostral medullary rap
he region (rMR) regulates sympathetic outflows to effector organs for home
ostasis. Thermal and infection stress inputs to the preoptic area of the h
ypothalamus dynamically alter the DMH→rMR transmission to elicit thermor
egulatory\, febrile\, and cardiovascular responses. Psychological stress s
ignaling from the prefrontal cortex to the DMH drives sympathetic and beha
vioral responses for stress coping\, representing a psychosomatic connecti
on from the corticolimbic emotion circuit to the autonomic and somatic mot
or systems. Under starvation stress\, medullary reticular neurons activate
d by hunger signaling from the hypothalamus suppress thermogenic drive fro
m the rMR for energy saving and prime mastication to promote food intake.
I will present a unified neural network for environmental stress responses
\, which provides novel insights into the integrative central regulation o
f organ functions that enables mammals to inhabit diverse environments on
earth.\nSpeaker: Kazuhiro Nakamura\, Ph.D.
LAST-MODIFIED:20230307T133750Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:diba.borgmann@sf.mpg.de
SUMMARY:Central neural network to defend life from environmental stresses:
Talk by Prof.Kazuhiro Nakamura\, Nagoya University\, Japan
URL;VALUE=URI:https://www.sf.mpg.de/events/33800/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/33201/1747887
DTSTART:20230119T130000Z
DTEND:20230119T140000Z
CLASS:PUBLIC
CREATED:20230103T171508Z
DESCRIPTION:Serotonin has wide-ranging effects on many physiological activi
ties\, from feeding and gut motility to mood and motor learning. However\,
the identity of central serotonergic neurons and the neuronal circuits wi
thin which they are embedded are largely unknown at single cell and synapt
ic level. We have used a scanning transmission electron microscopy dataset
of a whole Drosophila larva to elucidate the central sensory-motor circui
t that controls swallowing and its coordination with the enteric nervous s
ystem. The circuit is composed of Piezo-expressing mechanosensory neurons
arrayed along the esophagus which are able to sense the passage of food. T
heir afferent signal is conveyed onto a set of central serotonergic neuron
s that project back out via the larval vagus nerve and facilitates swallow
ing motor pattern. Serotonin release by these neurons modulates serotonin
receptor-expressing motor neurons that innervate the muscles underlying es
ophageal peristalsis. These motor neurons also share an efferent copy of t
heir motor activity with the Piezo neurons sensing food passage. Our analy
sis reveals an elemental circuit architecture through which successful com
pletion of a rewarding motor task provides a reinforcing and stabilizing s
ignal to the CNS for facilitation of motor learning.\nSpeaker: Michael Pan
kratz\, Prof. Dr. rer. nat.
LAST-MODIFIED:20230103T171736Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Serotonergic modulation of a feeding circuit along the brain-body
axis: Insights from a whole animal EM reconstruction of the enteric nervo
us system in Drosophila: Talk by Prof. Michael Pankratz\, LIMES Institute\
, Bonn University
URL;VALUE=URI:https://www.sf.mpg.de/events/33201/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/32716/1747887
DTSTART:20221110T100000Z
DTEND:20221110T110000Z
CLASS:PUBLIC
CREATED:20221024T144814Z
DESCRIPTION:The brain and body are in a continuous dialog that is essential
for our physical and mental health. Little is known about how this dialog
is achieved at the neurobiological level. A large corpus of work implicat
es the insular cortex as a central node for bi-directional brain-body comm
unication. However\, direct evidence for its functional role is scarce. We
developed a microprism-based cellular imaging approach to monitor insular
cortex activity in behaving mice across different physiological need stat
es. We combine this imaging approach with manipulations of peripheral phys
iology and related hypothalamic circuits to investigate the underlying mec
hanisms. I will first present our recent data suggesting that insular cort
ex population activity represents both current bodily states\, as well as
future predicted ones. I will then describe our current efforts to underst
and these predictions under conditions of conflicting physiological needs\
, and the potential role of these predictions in regulating bodily physiol
ogy.\nSpeaker: Yoav Livneh\, PhD
LAST-MODIFIED:20221024T144832Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:Brain-body interactions: sensations and predictions in insular cort
ex: Talk by Yoav Livneh\, Ph.D.\, Weizmann Institute\, Israel
URL;VALUE=URI:https://www.sf.mpg.de/events/32716/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/32388/1747887
DTSTART:20221027T120000Z
DTEND:20221027T130000Z
CLASS:PUBLIC
CREATED:20221004T153658Z
DESCRIPTION:Speaker: Prof. Dr. Martin Gericke
LAST-MODIFIED:20221004T154629Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:The role of adipose tissue macrophages in adipocyte degradation: T
alk by Prof. Martin Gericke\, Leipzig University
URL;VALUE=URI:https://www.sf.mpg.de/events/32388/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/32136/1747887
DTSTART:20220929T120000Z
DTEND:20220929T130000Z
CLASS:PUBLIC
CREATED:20220907T160852Z
DESCRIPTION:Speaker: Prof. Dr. William F. Colmers
LAST-MODIFIED:20220908T100315Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Prof. Jens Bruening:mailto:klingenberg@sf.mpg.de
SUMMARY:Adventures in NPY : Talk by Prof. William F. Colmers\, University o
f Alberta\, Canada
URL;VALUE=URI:https://www.sf.mpg.de/events/32136/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/31657/1747887
DTSTART:20220706T120000Z
DTEND:20220706T130000Z
CLASS:PUBLIC
CREATED:20220629T144257Z
DESCRIPTION:Psychedelics\, including psilocybin and LSD\, are undergoing a
“renaissance” as possible treatments for a range of psychiatric and ne
urological disorders\, especially because of their fast onset of therapeut
ic activity. There has been a rapid push to clinical trials since the 2018
designation of psilocybin as a “breakthrough therapy” by the US FDA\,
based on its efficacy in treatment-resistant depression\, including 4 cli
nical trials currently underway in patients with anorexia nervosa (AN). Wh
ile the outcomes of these trials will show efficacy one way or the other\,
it is imperative to understand the biological mechanisms through which ps
ilocybin may act to produce therapeutic outcomes\, in order to best direct
treatment to individuals likely to respond. This is especially important
given the climate of intense media hype that may bias the outcomes of clin
ical trials based on an expectation of efficacy. We have tested the effect
s of a single dose of psilocybin on the development of pathological weight
loss in the most well-established animal model of AN\, known as activity-
based anorexia\, and suggest a role for reinforcement learning and behavio
ural flexibility in the positive effects of psilocybin on energy balance.
We are now focused on uncovering the neurobiological substrates that under
pin these effects\, by examining changes in serotonin receptor expression
and the brain-derived neurotropic factor (BDNF) signalling pathway.\nSpeak
er: Dr. Claire Foldi
LAST-MODIFIED:20220629T144441Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Weiyi Chen:mailto:weiyi.chen@sf.mpg.de
SUMMARY:Targeting cognitive inflexibility to treat anorexia nervosa – ins
ights into the effects of psilocybin in animal models : Talk by Dr. Claire
Foldi\, Monash University Melbourne\, Australia
URL;VALUE=URI:https://www.sf.mpg.de/events/31657/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/31480/1747887
DTSTART:20220609T120000Z
DTEND:20220609T130000Z
CLASS:PUBLIC
CREATED:20220607T115653Z
DESCRIPTION:Speaker: Sebastien Bouret\, PhD
LAST-MODIFIED:20220607T120211Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY:The not so sweet effect of maternal diet on hypothalamic developmen
t: Talk by Sebastien Bouret\, Ph.D.\, University of Lille\, France
URL;VALUE=URI:https://www.sf.mpg.de/events/31480/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/31306/1747887
DTSTART:20220524T120000Z
DTEND:20220524T130000Z
CLASS:PUBLIC
CREATED:20220512T121954Z
DESCRIPTION:The Melanin-concentrating hormone (MCH) is a neuropeptide impli
cated in a wide range of functions. Its role is best described as an orexi
genic peptide since acute MCH applications induce an increase in food inta
ke. MCH-immunoreactive fibers (MCH-ir) are found diffused throughout virtu
ally the entire CNS. In contrast\, the production of MCH and messenger RNA
(mRNA) from its precursor (ppMCH) is concentrated\, in mammals\, in neuro
ns of two hypothalamic regions: the lateral hypothalamic area [LHA] and th
e incerto-hypothalamic area (IHy). Only during lactation\, MCH-ir neurons
and ppMCH mRNA expression appear in new hypothalamic territories\, such as
the ventromedial part of the medial preoptic area (vmMPOA). The amount of
MCH synthesis in this region increases with the progress of lactation\, b
eing maximum in the final phase [around 19th- 21st days] when it disappear
s. The origin of these cells is still unknown. A possible explanation for
this phenomenon is the de novo appearance or neuroplasticity of those cell
s in the vmMPOA region\, which would characterize the necessity of MCH sig
naling to decline the maternal behavior/lactation period of lactating fema
les.\nSpeaker: Jackson C. Bittencourt\, M.D.\, Ph.D.
LAST-MODIFIED:20220513T132022Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Bruening:mailto:klingenberg@sf.mpg.de
SUMMARY:The Melanin-Concentrating Hormone and the Maternal Behavior/Lactat
ion Period: Talk by Prof. Jackson C. Bittencourt\, University of São Paul
o\, Brazil
URL;VALUE=URI:https://www.sf.mpg.de/events/31306/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/30161/1747887
DTSTART:20220216T170000Z
DTEND:20220216T180000Z
CLASS:PUBLIC
CREATED:20220204T141759Z
DESCRIPTION:In aging populations\, questions around the processes of aging
become more and more pressing as aging-associated and neurodegenerative di
seases such as Alzheimer’s\, Parkinson’s and diabetes mellitus increas
ingly strain our health systems. Understanding the molecular mechanisms in
volved in degenerative aging processes can help develop new therapeutic ap
proaches that lead to a healthier way of living for older and ill individu
als\, and eventually for us all.\nSpeaker: Prof. Jens Brüning and Prof. A
ndrew Dillin
LAST-MODIFIED:20220204T143342Z
LOCATION:https://www.dwih-newyork.org/en/event/healthy-aging-brain-control-
of-longevity-and-metabolism/\, Room: Online
ORGANIZER;CN="Dr. Eva Bosbach, Executive Director, University of Cologne Ne
w York Office":mailto:
SUMMARY:Healthy Aging: Brain Control of Longevity and Metabolism: Transatla
ntic Tandem Talk
URL;VALUE=URI:https://www.sf.mpg.de/events/30161/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/23419/1747887
DTSTART:20200127T130000Z
DTEND:20200127T140000Z
CLASS:PUBLIC
CREATED:20200108T164905Z
DESCRIPTION:Interoception incorporates the afferent signalling\, central pr
ocessing and neural and mental representation of internal bodily signals.
Historically\, within the fields of physiology\, psychology and neuroscien
ce\, there has been inconsistency in the way that individual differences i
n interoception are defined and measured. This talk will detail empirical
results which demonstrate dimensions of interoception with and without con
scious access\, with a particular focus on the heart. In normative samples
\, these interoceptive dimensions are distinct and dissociable. The integr
ation of afferent signals with brain can augment or attenuate perceptive\,
cognitive and emotion processing. Selective alterations in interoceptive
processing are evident in clinical conditions such as schizophrenia and au
tism\, while specific interoceptive disturbances are associated with trans
diagnostic symptom expression such as anxiety and dissociation. Understand
ing the multifaceted nature of interoception and body-brain interactions c
an open up new avenues for targeted treatment.\nSpeaker: Prof. Sarah Garfi
nkel
LAST-MODIFIED:20200108T164905Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Clinical Neuroscience and the Heart-Brain Axis: Talk by Prof. Sarah
Garfinkel\, University of Sussex\, UK
URL;VALUE=URI:https://www.sf.mpg.de/events/23419/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/22079/1747887
DTSTART:20191108T130000Z
DTEND:20191108T140000Z
CLASS:PUBLIC
CREATED:20191024T093634Z
DESCRIPTION:Prompt behavioural reactions to external aversive stimuli are e
ssential for individual's survival. He will discuss the contribution of la
teral habenula in encoding such aversive stimuli in the brain and the impo
rtance of synaptic plasticity in this structure for behaviourally-relevant
events.\nSpeaker: Manuel Mameli\, PhD
LAST-MODIFIED:20191024T095514Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:Encoding of aversion in the lateral habenula: Talk by Prof. Manuel
Mameli\, PhD\, University of Lausanne\, Switzerland
URL;VALUE=URI:https://www.sf.mpg.de/events/22079/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/20132/1747887
DTSTART:20190916T120000Z
DTEND:20190916T130000Z
CLASS:PUBLIC
CREATED:20190827T112047Z
DESCRIPTION:The underlying basis for understanding of how brain control ene
rgy homeostasis\, resides in a functional and coordinate communicating pat
hways between peripheral endocrine organs and the brain\, in which the hyp
othalamus plays a pivotal role in the integration and processing of periph
eral metabolic cues into satiety and feeding signals. Based on human GWAS
and targeted mouse mutagenesis models\, it has recently been revealed that
obesity might due to a brain disease which might be a consequence of a br
ain misunderstanding the peripheral metabolic status in defense of body we
ightgain. As matter of fact\, a growing body of evidences demonstrate a li
nk between obesity and a defective brain´s nutrient/hormone sensing. Like
wise\, our studies have shown that hypothalamic astrocytes regulate glucos
e get access into the brain by sensing peripheral changes in insulin level
s and ultimately controlling feeding (García-Cáceres et al.\, Cell 2016)
. Using specific transgenic mouse models for targeting metabolic receptors
in these glial cells we have demonstrated that not only astrocytes respon
d to hormones derived from pancreas but also from adipose tissue (leptin)\
, as well as circulating nutrients (lipids\, glucose) (Kim et al.\, Nature
Neurosci. 2014\; Gao et al.\, Diabetes 2018\; García-Cáceres et al.\, C
ell 2016). Overall our previous work supports that hormone/nutrient signal
ing in astrocytes is determinant of the manner in which brain sense whole-
body metabolic demands. We are now continuing on investigating whether hyp
othalamic astrocyte-neuron circuits require a precise finely-tuned and coo
rdinated communication with metabolic cues derived from peripheral endocri
ne organ for maintaining a balanced control of food intake\, body weight a
nd metabolism. Furthermore\, we hypothesize that impairment of such crosst
alk during exposure to hypercaloric environments may contribute to the pat
hogenesis of obesity and type-2 diabetes. To test this overarching hypothe
sis\, we are developing a functional mouse model for understanding of body
-brain connection with particular focus on the role of astrocytes for the
control of body weight and energy metabolism in health and disease.\nSpeak
er: Dr. Cristina García Cáceres
LAST-MODIFIED:20190827T113246Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN="Alain de Solis, Ph.D":mailto:alain.desolis@sf.mpg.de
SUMMARY:Astrocytes emerge as key players in the control of metabolism: Talk
by Dr. Cristina García Cáceres\, Helmholtz Zentrum München
URL;VALUE=URI:https://www.sf.mpg.de/events/20132/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/19561/1747887
DTSTART:20190909T120000Z
DTEND:20190909T130000Z
CLASS:PUBLIC
CREATED:20190719T133359Z
DESCRIPTION: Protein kinases are the key components of almost every signall
ing pathway involved in normal development and disease. MAPKs play a key r
ole in the regulation of diverse cellular programs and participate extensi
vely in the control of cell fate decisions such as proliferation\, differe
ntiation\, and death\, as well as in the regulation of stress responses. T
he main stress-activated MAPKs are the p38 and c-Jun N-terminal kinase (JN
K) families. The p38MAPK family has four isoforms encoded by distinct gene
s located tandemly in 2 chromosomes: p38\, \, and . Althoug
h the role of all p38s have been thought to be similar\, we think the less
-studied members p38 and have different and specific regulation and
function. We will discuss about our recent findings that suggest that the
se kinases have specific function and regulation. We will focus our attent
ion in their implication in obesity related diseases.\nSpeaker: Guadalupe
Sabio\, DVM\, PhD
LAST-MODIFIED:20190719T133608Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Unravelling the role of p38 and p38 in obesity-related disea
ses: Talk by Guadalupe Sabio\, PhD\, Centro Nacional de Investigaciones Ca
rdiovasculares Carlos III\, Madrid\, Spain
URL;VALUE=URI:https://www.sf.mpg.de/events/19561/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/18593/1747887
DTSTART:20190520T120000Z
DTEND:20190520T130000Z
CLASS:PUBLIC
CREATED:20190503T111806Z
DESCRIPTION: Obesity is intertwined with behaviour. Many eating-related beh
aviours have been proposed to explain obesity\, such as food addiction\, d
isinhibition and emotional eating. However\, these behaviours tend to simi
larities based on both statistics and definitions. I propose that these be
haviours can be aggregated into a single broad trait – Uncontrolled Eati
ng. Such an approach enables reviewing and meta‐analysing evidence done
on each individual behaviour. I review evidence how the aggregated Uncontr
olled Eating has robust associations with body mass index\, food intake\,
personality traits\, and brain systems. I also map out Uncontrolled Eating
’s behavioural similarity with other addictions and psychiatric conditio
ns. In summary\, Uncontrolled Eating summarises important behavioural aspe
cts of obesity.\nSpeaker: Uku Vainik\, PhD
LAST-MODIFIED:20190503T113416Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Uncontrolled eating: a unifying heritable trait linked with obesit
y\,overeating\, personality and the brain: Talk by Dr. Uku Vainik\, Univer
sity of Tartu\, Estonia
URL;VALUE=URI:https://www.sf.mpg.de/events/18593/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/18180/1747887
DTSTART:20190425T120000Z
DTEND:20190425T130000Z
CLASS:PUBLIC
CREATED:20190328T171805Z
DESCRIPTION: The brain relies on glucose for fuel but has limited storage c
apacity. To facilitate adequate glucose availability\, the brain senses gl
ucose\, initiates feeding behaviour\, and controls system glucose metaboli
sm. To date\, the majority of studies investigating the sensing and centra
l control of glucose have focused on the hypothalamus and the brainstem. H
owever\, recent findings have revealed an unexpected and fascinating role
for the striatum\, a brain nucleus mainly known for its role in reward beh
aviour\, in glucose homeostasis. I will present a series of experiments\,
in both humans and rodents\, supporting the regulation of peripheral gluco
se metabolism by striatal dopamine signaling. With rodent studies we also
unraveled the neural route via which the striatum\, and especially the nuc
leus accumbens shell\, communicates with the liver to regulate glucose pro
duction.\nSpeaker: Prof. Susanne la Fleur
LAST-MODIFIED:20190328T171805Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Striatal glucose regulates systemic glucose metabolism in humans a
nd rodents: Talk by Prof. Susanne la Fleur\, University of Amsterdam
URL;VALUE=URI:https://www.sf.mpg.de/events/18180/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/18023/1747887
DTSTART:20190408T120000Z
DTEND:20190408T130000Z
CLASS:PUBLIC
CREATED:20190312T171441Z
DESCRIPTION:Speaker: Anna Beyeler\, PhD
LAST-MODIFIED:20190312T171441Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:Link valence and anxiety in the amygdala and insular cortex : Talk
by Prof. Anna Beyeler
URL;VALUE=URI:https://www.sf.mpg.de/events/18023/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/17718/1747887
DTSTART:20190225T130000Z
DTEND:20190225T141500Z
CLASS:PUBLIC
CREATED:20190213T145342Z
DESCRIPTION:Speaker: Prof. Tune Hannes Pers\, PhD
LAST-MODIFIED:20190213T145832Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Henning Fenselau:mailto:henning.fenselau@sf.mpg.de
SUMMARY:Leveraging human genetics to identify brain cell types modulating s
usceptibility to obesity.: Talk by Prof. Tune Hannes Peers\, University of
Copenhagen
URL;VALUE=URI:https://www.sf.mpg.de/events/17718/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/17514/1747887
DTSTART:20190220T150000Z
DTEND:20190220T160000Z
CLASS:PUBLIC
CREATED:20190125T141738Z
DESCRIPTION:Speaker: Ana Domingos\, PhD
LAST-MODIFIED:20190125T141738Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:NeuroImmunoMetabolism: Talk by Prof. Ana Domingos\, University of O
xford
URL;VALUE=URI:https://www.sf.mpg.de/events/17514/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/17063/1747887
DTSTART:20190122T130000Z
DTEND:20190122T140000Z
CLASS:PUBLIC
CREATED:20181219T151748Z
DESCRIPTION:Speaker: Christian Ruff\, PhD
LAST-MODIFIED:20181219T151748Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Dazed and confused? Neural origins of behavioral variability in va
lue-based food choice. : Talk by Prof. Christian Ruff\, University of Zur
ich
URL;VALUE=URI:https://www.sf.mpg.de/events/17063/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/15710/1747887
DTSTART:20181105T130000Z
DTEND:20181105T140000Z
CLASS:PUBLIC
CREATED:20181010T125956Z
DESCRIPTION: When interacting with their environment animals constantly mak
e decisions. These decisions frequently aim at maximizing reward while avo
iding negative consequences such as energy costs\, pain\, or long-term dis
advantages. Faced with a choice\, animals consider and integrate several p
arameters such as their internal and behavioral state as well as external
stimuli. Often decisions are shaped by prior experiences such as exposure
to a given stimulus in a certain condition. But preferences and aversions
can be innate\, and an instinctive reaction can be essential to secure sur
vival. Nevertheless\, even these innate preferences need to be evaluated i
n a context-dependent manner and hence\, context strongly impinges on beha
vior. While it is generally accepted that context influences behavior\, ou
r knowledge of the neural mechanisms of how internal state and external co
nditions alter ongoing behavior is scarce. The goal of my research is to p
rovide a comprehensive understanding of the neural and molecular basis of
context-specific behavior. To this end\, my group studies how internal sta
tes shape chemosensory processing and behavior. In this talk\, I will pres
ent two examples of our recent work in the fly on reproductive state-depen
dent decision making and on the role of need and motivation in foraging be
havior.\nSpeaker: Prof. Dr. Ilona Grunwald Kadow
LAST-MODIFIED:20181010T125956Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY: How states and needs shape neural processing and behavior of frui
tflies : Talk by Prof. Ilona Grunwald Kadodw\, TU München
URL;VALUE=URI:https://www.sf.mpg.de/events/15710/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/15587/1747887
DTSTART:20181019T130000Z
DTEND:20181019T140000Z
CLASS:PUBLIC
CREATED:20181002T155936Z
DESCRIPTION: Mammals\, including rodents show a broad range of defensive be
haviors as a mean of coping with threatful stimuli including freezing and
avoidance behaviors. Several studies emphasized the role of the dorsal med
ial prefrontal cortex (dmPFC) in encoding the acquisition as well as the e
xpression of freezing behavior. However the role of this structure in proc
essing avoidance behavior and the contribution of distinct prefrontal circ
uits to both freezing and avoidance responses are largely unknown. To furt
her investigate the role of dmPFC circuits in encoding passive and active
fear-coping strategies\, we developed in the laboratory a novel behavioral
paradigm in which a mouse has the possibility to choose either to passive
ly freeze to an aversive stimulus or to actively avoid it as a function of
contextual contingencies. Using this behavioral paradigm we investigated
whether the same circuits mediate freezing and avoidance behaviors or if d
istinct neuronal circuits are involved. To address this question\, we used
a combination of behavioral\, neuronal tracing\, immunochemistry\, single
unit and patch clamp recordings and optogenetic approaches. Our results i
ndicate that (i) dmPFC and dorsolateral and lateral periaqueductal grey (d
l/lPAG) sub-regions are activated during avoidance behavior\, (ii) a subpo
pulation of dmPFC neurons encode avoidance but not freezing behavior\, (ii
i) this neuronal population project to the dl/lPAG\, (iv) the optogenetic
activation or inhibition of this pathway promoted and blocked the acquisit
ion of conditioned avoidance and (v) avoidance learning was associated wit
h the development of plasticity at dmPFC to dl/lPAG synapses. Together\, t
hese data demonstrate for the first time that activity-dependent plasticit
y in a subpopulation of dmPFC cells projecting to the dl/lPAG pathway cont
rols avoidance learning.\nSpeaker: Dr. Cyril Herry
LAST-MODIFIED:20181002T155936Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:A prefrontal-brainstem pathway mediating active fear behavior : Ta
lk by Dr. Cyril Herry\, University of Bordeaux
URL;VALUE=URI:https://www.sf.mpg.de/events/15587/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/15349/1747887
DTSTART:20180927T120000Z
DTEND:20180927T130000Z
CLASS:PUBLIC
CREATED:20180913T161301Z
DESCRIPTION:Speaker: Dr. Tom Schonberg
LAST-MODIFIED:20180913T161323Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:New behavioral and imaging findings with the cue-approach paradigm:
A non-reinforced mechanism of behavior change: Talk by Dr. Tom Schonberg\
, Tel Aviv University
URL;VALUE=URI:https://www.sf.mpg.de/events/15349/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/15180/1747887
DTSTART:20180917T120000Z
DTEND:20180917T130000Z
CLASS:PUBLIC
CREATED:20180906T135111Z
DESCRIPTION: Sleep architecture carries important information about brain h
ealth. Here we show that active compared to quiet sleep in infants heralds
a marked change from long- to short-range functional connectivity across
broad-frequency neural activity. This change in cortical connectivity is a
ttenuated following preterm birth and pre-empts visual performance at two
years. Biophysical modeling shows that active sleep is defined by reduced
energy in a large-scale\, uniform mode of spatiotemporal neural activity a
nd increased energy in two non-uniform anteroposterior modes. This distinc
t energy redistribution leads to the emergence of more complex connectivit
y patterns in active sleep compared to quiet sleep. Preterm-born infants s
how an attenuation in this sleep-related reorganization of connectivity th
at carries novel prognostic information.\nSpeaker: Prof. Michael Breakspea
r
LAST-MODIFIED:20180906T135111Z
LOCATION:Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Large-scale brain modes reorganize between infant sleep states and
predict developmental outcome in preterms: Talk by Prof. Michael Breakspea
r\, QIMR Berghofer Medical Research Institute\, Brisbane\, Australia
URL;VALUE=URI:https://www.sf.mpg.de/events/15180/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/14507/1747887
DTSTART:20180712T120000Z
DTEND:20180712T130000Z
CLASS:PUBLIC
CREATED:20180627T121401Z
DESCRIPTION:Speaker: Dr. Michael Krashes
LAST-MODIFIED:20180702T103720Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:mafalda.pereira@sf.mpg.de
SUMMARY:Defined Paraventricular Hypothalamic Populations Exhibit Differenti
al Responses Contingent on Caloric State: Talk by Dr Michael Krashes\, NID
DK/NIH\, Bethesda\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/14507/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/13837/1747887
DTSTART:20180525T140000Z
DTEND:20180525T150000Z
CLASS:PUBLIC
CREATED:20180420T115002Z
DESCRIPTION:Speaker: Prof. Anthony A. Grace
LAST-MODIFIED:20180518T134403Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:The Circuitry of Depression: New Findings on Postpartum Depression:
Talk by Prof. Anthony A. Grace\, University of Pittsburgh
URL;VALUE=URI:https://www.sf.mpg.de/events/13837/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/13918/1747887
DTSTART:20180523T120000Z
DTEND:20180523T130000Z
CLASS:PUBLIC
CREATED:20180427T145129Z
DESCRIPTION:Speaker: Prof. Ingo Willuhn
LAST-MODIFIED:20180427T150004Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:Regionally distinct dopamine fluctuations in the striatum exhibit h
eterogeneous function in the regulation of motivated behavior: Talk by Pro
f. Ingo Willuhn\, Netherlands Institute for Neuroscience
URL;VALUE=URI:https://www.sf.mpg.de/events/13918/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/13736/1747887
DTSTART:20180423T120000Z
DTEND:20180423T130000Z
CLASS:PUBLIC
CREATED:20180413T140405Z
DESCRIPTION:Speaker: Prof. Jan Siemens
LAST-MODIFIED:20180413T140803Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Tatiana Korotkova:mailto:tatiana.korotkova@sf.mpg.de
SUMMARY:TRP ion channels – multimodal sensors and Guardians of homeostasi
s: Talk by Prof. Jan Siemens\, University of Heidelberg
URL;VALUE=URI:https://www.sf.mpg.de/events/13736/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/12968/1747887
DTSTART:20180305T130000Z
DTEND:20180305T140000Z
CLASS:PUBLIC
CREATED:20180215T161955Z
DESCRIPTION:Late onset diseases such as cancer and neurodegenerative diseas
es represent an enormous burden in our ageing population. An in depth unde
rstanding of molecular pathomechanisms is a prerequisite for the developme
nt of novel treatment strategies. Our major research interest is in regula
tory RNA-protein interactions\, an important and often overlooked cellular
phenomenon that plays an essential role in disease-development. RNA-funct
ion depends on the 3-dimensional structure of the RNA as well as on intera
ction with RNA-binding proteins. The main goal of our research is to ident
ify and characterize regulatory RNA-protein interactions in healthy and di
sease tissue\, especially in late onset diseases such as cancer and neurod
egenerative diseases.In my group\, we have identified an RNA-protein compl
ex containing the ubiquitin ligase MID1 that plays an important role in re
gulating protein synthesis and that is significantly upregulated in late o
nset diseases including Huntington’s disease\, Alzheimer’s disease or
certain types of cancer. This aberrant MID1-activity leads to an increased
protein production of proteins that are causal for disease-development.Th
us\, our data suggest that MID1 is a key regulator in disease development.
Furthermore\, our preliminary results indicate that MID1 localizes to cyt
osolic RNA granules and interacts with proteins involved in RNA granule as
sembly\, RNA transport and local protein synthesis. In our ongoing experim
ents we further investigate the exact molecular function of MID1 and its i
nteractome\, especially focusing on the molecular pathways that are trigge
red by MID1 over-expression in disease tissue. Interestingly\, these pathw
ays include mTOR-signaling and insulin / insulin-like growth factor-1 (IGF
-1) signaling pathways.\nSpeaker: Dr. Sybille Krauß
LAST-MODIFIED:20180215T161955Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Abberrant RNA-protein interactions in late-onset diseases: Talk by
Dr. Sybille Krauß\, DZNE Bonn
URL;VALUE=URI:https://www.sf.mpg.de/events/12968/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11625/1747887
DTSTART:20180205T130000Z
DTEND:20180205T140000Z
CLASS:PUBLIC
CREATED:20171117T112318Z
DESCRIPTION: Visceral organs have long been believed to act as major regula
tors of emotional state. However\, the specific role of gut-borne signals
in motivated behavior remains elusive to this day. The talk will describe
the connectivity and behavioral functions of a neural circuit that links g
ut sensory neurons to brain reward systems. Implications for our current i
deas on the role of the gut-brain axis will be discussed.\nSpeaker: Ivan d
e Araujo\, DPhil
LAST-MODIFIED:20171211T150722Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:The gut-brain axis and reward : Talk by Dr. Ivan de Araujo\, Yale S
chool of Medicine
URL;VALUE=URI:https://www.sf.mpg.de/events/11625/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/12433/1747887
DTSTART:20180129T130000Z
DTEND:20180129T140000Z
CLASS:PUBLIC
CREATED:20180109T162925Z
DESCRIPTION:Speaker: Prof. Dr. Harald Möller
LAST-MODIFIED:20180109T163158Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Insights into Brain Metabolism by quantitative MRI: An Approach fr
om Physics : Talk by Prof. Dr. Harald Möller\, MPI for Human Cognitive an
d Brain Sciences\, Leipzig
URL;VALUE=URI:https://www.sf.mpg.de/events/12433/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11526/1747887
DTSTART:20171208T080000Z
DTEND:20171208T163000Z
CLASS:PUBLIC
CREATED:20171108T162735Z
DESCRIPTION: On December 8\, 2017\, the 6th CGA Graduate Symposium w
ill take place at the Max Planck Institute for Biology of Ageing. This fes
tive Symposium takes place annually to celebrate the graduating students t
hat have successfully completed their CGA curriculum. Twelve graduate stud
ents will present their work in different areas of ageing research. Each s
ession will be accompanied by a key note lecture given by an invited\, int
ernational renowned expert in ageing research. Our key note speakers will
be Hayley Nicholls from Boston\, U.S.A.\, David Tollervey from Edinburgh\,
UK and Marina Mapelli from Milan\, Italy.Sponsored by Eppendorf\, New Eng
land Biolabs\, Eppendorf\, Promega and Techniker Krankenkasse\nSpeaker: Di
verse
LAST-MODIFIED:20171117T090508Z
LOCATION:MPI for Biology of Ageing\, Joseph-Stelzmann-Strasse 9b\, Cologne\
, Room: Lecture Hall
ORGANIZER;CN=Cologne Graduate School of Ageing Research:mailto:
SUMMARY:Graduating class of 2014: 6th CGA Graduate Symposium
URL;VALUE=URI:https://www.sf.mpg.de/events/11526/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11462/1747887
DTSTART:20171127T130000Z
DTEND:20171127T140000Z
CLASS:PUBLIC
CREATED:20171102T162052Z
DESCRIPTION:Speaker: Prof. Stephen Smith
LAST-MODIFIED:20171102T162052Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Big Data Neuroimaging Studies – HCP and UK Biobank : Talk by Ste
phen Smith\, Professor of Biomedical Engineering\, University of Oxford
URL;VALUE=URI:https://www.sf.mpg.de/events/11462/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11468/1747887
DTSTART:20171121T130000Z
DTEND:20171121T140000Z
CLASS:PUBLIC
CREATED:20171103T130614Z
DESCRIPTION:Speaker: Sebastien Bouret\, PhD
LAST-MODIFIED:20171103T130919Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY:Developmental Programming of Hypothalamic Feeding Circuits: Talk b
y Sebastien Bouret\, PhD\, University of California\, LA\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/11468/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11422/1747887
DTSTART:20171120T140000Z
DTEND:20171120T150000Z
CLASS:PUBLIC
CREATED:20171027T150716Z
DESCRIPTION:Brown adipose tissue (BAT) has the unique capacity to regulate
energy expenditure by a process called adaptive thermogenesis\, which diss
ipates chemical energy to produce heat. If fully active\, the BAT depots o
f adult humans may burn an amount of energy equivalent to about 4 kg of wh
ite adipose tissue (WAT) per year. Needless to say\, the identification of
BAT in adult humans opens up completely new avenues of therapeutic interv
ention and offers unique scientific opportunities. This entails a need to
better understand the molecular mechanisms that regulate BAT metabolism. T
his presentation is focused on how BAT\, WAT and muscle regulate its uptak
e and use of substrates for metabolism and how this affects the function o
f these tissues. These studies have led to identification of transcription
factors that regulate cellular glycolysis and substrate preference i.e. g
lucose or fatty acid uptake and further oxidation.\nSpeaker: Prof. Sven En
erbäck
LAST-MODIFIED:20171027T151239Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:Metabolic regulation in adipose tissue\, muscle and possibly also i
n the brain: Talk by Prof. Sven Enerbäck\, University of Gothenburg
URL;VALUE=URI:https://www.sf.mpg.de/events/11422/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11147/1747887
DTSTART:20171018T120000Z
DTEND:20171018T130000Z
CLASS:PUBLIC
CREATED:20170928T102802Z
DESCRIPTION:Speaker: Kim Ravnskjær\, PhD
LAST-MODIFIED:20170928T123837Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Global Analyses of Hepatic Stellate Cell Biology: Talk by Kim Ravns
kjær\, PhD\, University of Southern Denmark
URL;VALUE=URI:https://www.sf.mpg.de/events/11147/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11191/1747887
DTSTART:20171016T120000Z
DTEND:20171016T130000Z
CLASS:PUBLIC
CREATED:20171005T104701Z
DESCRIPTION:Speaker: Prof. Dr. Dominik Schenten
LAST-MODIFIED:20171005T105303Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Functions of Cytosolic Pattern Recognition Receptors in the Regulat
ion of Adaptive Immunity: Talk by Prof. Dr. Dominik Schenten\, University
of Arizona
URL;VALUE=URI:https://www.sf.mpg.de/events/11191/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/11123/1747887
DTSTART:20170925T120000Z
DTEND:20170925T130000Z
CLASS:PUBLIC
CREATED:20170922T094634Z
DESCRIPTION:Speaker: PD Dr. Michael Potente
LAST-MODIFIED:20170922T095308Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Metabolic regulation of endothelial growth and quiescence: Talk by
PD Dr. Michael Potente\, MPI for Heart and Lung Research\, Bad Nauheim Bad
Nauheim
URL;VALUE=URI:https://www.sf.mpg.de/events/11123/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/10552/1747887
DTSTART:20170915T120000Z
DTEND:20170915T130000Z
CLASS:PUBLIC
CREATED:20170718T125702Z
DESCRIPTION:Speaker: Professor Mark A. Febbraio\, PhD
LAST-MODIFIED:20170718T130647Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:klingenberg@sf.mpg.de
SUMMARY:The chameleon role of TLR4 in lipid-induced macrophage inflammatio
n: Talk by Prof. Mark Febbraio\, Garvan Institute of Medical Research\, Sy
dney
URL;VALUE=URI:https://www.sf.mpg.de/events/10552/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/10348/1747887
DTSTART:20170705T120000Z
DTEND:20170705T130000Z
CLASS:PUBLIC
CREATED:20170620T152032Z
DESCRIPTION: Understanding the functional communication across brain has be
en a long sought-after goal of neuroscientists. However\, due to the wides
pread and highly interconnected nature of brain circuits\, the dynamic rel
ationship between neuronal network elements remains elusive. With the deve
lopment of optogenetic functional magnetic resonance imaging (ofMRI)\, it
is now possible to observe whole-brain level network activity that results
from modulating with millisecond-timescale resolution the activity of gen
etically\, spatially\, and topologically defined cell populations. ofMRI u
niquely enables mapping global patterns of brain activity that result from
the selective and precise control of neuronal populations. Advances in th
e molecular toolbox of optogenetics\, as well as improvements in imaging t
echnology\, will bring ofMRI closer to its full potential. In particular\,
the integration of ultra-fast data acquisition\, high SNR\, and combinato
rial optogenetics will enable powerful systems that can modulate and visua
lize brain activity in real-time. ofMRI is anticipated to play an importan
t role in the dissection and control of network-level brain circuit functi
on and dysfunction. In this talk\, the ofMRI technology will be introduced
with advanced approaches to bring it to its full potential\, ending with
examples of dissecting whole brain circuits associated with neurological d
iseases utilizing ofMRI.\nSpeaker: Jin Hyung Lee\, PhD
LAST-MODIFIED:20170620T152032Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Optogenetic fMRI and the Investigation of Global Brain Circuit Mech
anisms: Talk by Jin Hyung Lee\, PhD\, Stanford University
URL;VALUE=URI:https://www.sf.mpg.de/events/10348/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/10127/1747887
DTSTART:20170626T120000Z
DTEND:20170626T130000Z
CLASS:PUBLIC
CREATED:20170602T120943Z
DESCRIPTION:Change notice: CANCELLED\nSpeaker: Dr. Riekelt H. Houtkooper
LAST-MODIFIED:20170626T085920Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Pharmacological approaches to restore mitochondrial function : Tal
k by Riekelt Houtkooper\, PhD\, Academic Medical Center Amsterdam
URL;VALUE=URI:https://www.sf.mpg.de/events/10127/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/10017/1747887
DTSTART:20170529T120000Z
DTEND:20170529T130000Z
CLASS:PUBLIC
CREATED:20170516T131129Z
DESCRIPTION:Type 2 diabetes (T2D) is a complex genetic metabolic disorder w
hich has developed into major health problem responsible for early morbidi
ties (e.g. severe vascular complications and cancers) and mortality\, with
a burden increasing globally. T2D results from the progressive alteration
of insulin secretion from pancreatic beta cells on a background of impair
ed insulin action in sensitive organs and tissues. Whilst the environment
is the key risk factor for T2D at the population level\, one remarkable fe
ature is the persistence of considerable individual disease risk amongst p
eople sharing same environment. Estimates of T2D heritability range from 4
0 to 70%. Genome-wide association studies (GWAS) have identified >\;100
loci independently contributing to T2D risk. Despite this dramatic success
\, there has been a considerable gap between the knowledge of the genetic
contribution of these loci and the understanding of how these loci physiol
ogically impact the disease: indeed\, association does not mean causality.
Therefore\, translational implications for precision medicine and for the
development of novel treatments have been disappointing\, due to the poor
knowledge of how these loci impact T2D pathophysiology. During my talk\,
I will present several post-GWAS functional studies which enabled the iden
tification of causal genes and pathways involved in T2D pathophysiology.
LAST-MODIFIED:20170516T132854Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Post-GWAS functional analyses of variants (and proxy genes) associa
ted with type 2 diabetes: Talk by Amélie Bonnefond\, PhD\, University of
Lille
URL;VALUE=URI:https://www.sf.mpg.de/events/10017/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9706/1747887
DTSTART:20170515T120000Z
DTEND:20170515T130000Z
CLASS:PUBLIC
CREATED:20170425T124434Z
DESCRIPTION: The MC4R regulates energy homeostasis\, and haploinsufficiency
produces hyperphagia\, hypometabolism\, and early onset obesity. In contr
ast\, homozygous deletion of the MC3R does not cause hyperphagia or hypome
tabolism under normal conditions\, producing a mild\, late-onset obesity.
However\, the MC3R plays a critical role in regulating energy homeostasis
in response to external and internal nutritional challenges. First\, the M
C3R regulates energy stores in response to fasting and chronic food restri
ction. Additionally\, there are multiple roles for MC3R in regulation of e
nergy homeostasis in response to reproductive state. MC3R KO mice exhibit
defective pregnancy-induced hyperphagia and defective control of energy st
ores in response to ovariectomy. Thus\, MC3R deletion results in defective
homeostatic boundary control and rheostasis. Additional data demonstrate
a molecular mechanism by which MC3R regulates homeostatic boundary control
: MC3R on AgRP neurons acts presynaptically to provide autoregulatory feed
back onto MC4R PVN neurons.\nSpeaker: Roger D. Cone\, Ph.D.
LAST-MODIFIED:20170425T125245Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Rachel Lippert:mailto:rachel.lippert@sf.mpg.de
SUMMARY:Regulation of Homeostatic Boundary Control and Rheostasis by the M
elanocortin-3 Receptor: Talk by Professor Roger Cone\, University of Michi
gan\, USA
URL;VALUE=URI:https://www.sf.mpg.de/events/9706/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9875/1747887
DTSTART:20170511T120000Z
DTEND:20170511T130000Z
CLASS:PUBLIC
CREATED:20170505T130516Z
DESCRIPTION:Speaker: Dr. Arthur Liesz
LAST-MODIFIED:20170505T130904Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Mathias Hoehn:mailto:mathias@sf.mpg.de
SUMMARY:Immunological Mechanisms in Ischemic Stroke: Talk by Dr. Arthur Lie
sz\, LMU Munich
URL;VALUE=URI:https://www.sf.mpg.de/events/9875/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9870/1747887
DTSTART:20170508T120000Z
DTEND:20170508T131500Z
CLASS:PUBLIC
CREATED:20170504T151605Z
DESCRIPTION:14:00 Welcome address14:15 - 14:45 Dr. Henning Fenselau: " Syna
ptic transmission and plasticity in feeding circuits"14:45 - 15:15 Dr. Chr
istophe Lamy: "Brain glucose sensing and the control of energy homeostasis
and behavior"\nSpeaker: Dr. Henning Fenselau\, Dr. Christophe Lamy
LAST-MODIFIED:20170504T152207Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:
SUMMARY:Selection workshop for Independent Research Group Leader position:
Selection Workshop for Independent Research Group Leader Position
URL;VALUE=URI:https://www.sf.mpg.de/events/9870/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9397/1747887
DTSTART:20170424T120000Z
DTEND:20170424T130000Z
CLASS:PUBLIC
CREATED:20170315T152232Z
DESCRIPTION:Speaker: Prof. Paul Fletcher
LAST-MODIFIED:20170315T152232Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:A cognitive neuroscientific approach to eating and over-eating : T
alk by Professor Paul Fletcher\, Cambridge
URL;VALUE=URI:https://www.sf.mpg.de/events/9397/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9420/1747887
DTSTART:20170328T120000Z
DTEND:20170328T130000Z
CLASS:PUBLIC
CREATED:20170320T152740Z
DESCRIPTION:Speaker: Dr. Martin Pal
LAST-MODIFIED:20170320T153300Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Engineering the mouse genome using CRISPR/Cas9 technology : Talk b
y Dr. Martin Pal
URL;VALUE=URI:https://www.sf.mpg.de/events/9420/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/9418/1747887
DTSTART:20170327T120000Z
DTEND:20170327T130000Z
CLASS:PUBLIC
CREATED:20170320T152258Z
DESCRIPTION:Speaker: Dr. Charo Robles
LAST-MODIFIED:20170320T153244Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Quantitative proteomics to study circadian control of metabolism: T
alk by Dr. Charo Robles
URL;VALUE=URI:https://www.sf.mpg.de/events/9418/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/8734/1747887
DTSTART:20170216T123000Z
DTEND:20170216T133000Z
CLASS:PUBLIC
CREATED:20170119T164905Z
DESCRIPTION:Speaker: Prof. Jeffrey Friedman
LAST-MODIFIED:20170119T165146Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:
SUMMARY:Leptin and the Neural Circuit Regulating Food Intake and Metabolis
m: Talk by Jeffrey Friedman\, MD\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/8734/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/8753/1747887
DTSTART:20170209T130000Z
DTEND:20170209T140000Z
CLASS:PUBLIC
CREATED:20170120T160547Z
DESCRIPTION: The hippocampus is a brain area that is involved in a variety
of functions. In particular\, the formation of memory and the codification
of space depend on the functioning of the hippocampus. Virtually all area
s of the hippocampus\, and of most parts of the brain\, contain excitatory
and inhibitory neurons that form individual microcircuits. It is in the i
nteraction between excitatory and inhibitory circuits where appropriate fu
nctional responses arise. We study how excitation and inhibition interact
to activate neurons in the dentate gyrus of the hippocampus\, one of the o
nly regions of the brain in which new neurons are formed throughout life.
In this seminar I will present experiments using electrophysiology and cal
cium imaging aiming to understand the functional role of newborn neurons i
n the processing of afferent stimuli\, with the focus on the synaptic mech
anism that generate the unique properties they present.\nSpeaker: Antonia
Marin - Burgin\, PhD
LAST-MODIFIED:20170120T160547Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:
SUMMARY:Interaction among excitatory and inhibitory circuits in the hippoc
ampus: Talk by Dr. Antonia Marin-Burgin
URL;VALUE=URI:https://www.sf.mpg.de/events/8753/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/8287/1747887
DTSTART:20170130T130000Z
DTEND:20170130T140000Z
CLASS:PUBLIC
CREATED:20170104T170358Z
DESCRIPTION: Formaldehyde is a highly reactive chemical used as a preservat
ive and also in many industrial processes. In our cells\, this aldehyde is
generated as a by-product of several essential biochemical pathways. This
‘endogenous’ formaldehyde is very reactive and can damage proteins an
d DNA resulting in lethal toxicity. Therefore\, cells harbour two protecti
ve barriers: the formaldehyde-detoxifying enzyme alcohol dehydrogenase 5 (
Adh5) and the Fanconi Anemia DNA repair pathway. The simultaneous inactiva
tion of these two systems leads to haematopoietic stem cell attrition\, ki
dney and liver dysfunction\, and development of cancer in mice. My work ai
ms to understand the molecular mechanisms that counteract unwanted consequ
ences of essential metabolism.\nSpeaker: Dr. Lucas Pontel
LAST-MODIFIED:20170104T171122Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:ismene.karakasilioti@sf.mpg.de
SUMMARY:Endogenous formaldehyde: a stem cell genotoxin and metabolic carcin
ogen in mammals: Talk by Dr. Lucas Pontel
URL;VALUE=URI:https://www.sf.mpg.de/events/8287/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/8288/1747887
DTSTART:20170109T130000Z
DTEND:20170109T140000Z
CLASS:PUBLIC
CREATED:20170104T174515Z
DESCRIPTION:Speaker: Prof. Kohjiro Ueki
LAST-MODIFIED:20170104T174517Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN="Dr. Motoharu Awazawa, Prof. Jens Brüning":mailto:
SUMMARY:Role of Activin B as a novel hepatokine in the regulation of gluco
se homeostasis : Talk by Prof. Kohjiro Ueki
URL;VALUE=URI:https://www.sf.mpg.de/events/8288/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7845/1747887
DTSTART:20161221T100000Z
DTEND:20161221T110000Z
CLASS:PUBLIC
CREATED:20161202T143202Z
DESCRIPTION:Speaker: Prof. Alexander Tarakhovsky\, MD\, PhD
LAST-MODIFIED:20161202T143205Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:ismene.karakasilioti@sf.mpg.de
SUMMARY:Histone Mimicry by Viruses: Talk by Prof. Alexander Tarakhovsky\, R
ockefeller University\, New York
URL;VALUE=URI:https://www.sf.mpg.de/events/7845/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7769/1747887
DTSTART:20161214T140000Z
DTEND:20161214T150000Z
CLASS:PUBLIC
CREATED:20161124T162129Z
DESCRIPTION:Change notice: Lecture starts at 15:00\nSpeaker: Zachary Knight
\, PhD
LAST-MODIFIED:20161213T102513Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:ismene.karakasilioti@sf.mpg.de
SUMMARY:The Neurobiology of Homeostasis : Talk by Zachary Knight\, PhD\, Un
iversity of California San Francisco
URL;VALUE=URI:https://www.sf.mpg.de/events/7769/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7811/1747887
DTSTART:20161209T100000Z
DTEND:20161209T110000Z
CLASS:PUBLIC
CREATED:20161129T154230Z
DESCRIPTION:Speaker: Sebastien Bouret\, PhD
LAST-MODIFIED:20161129T154456Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sophie Steculorum:mailto:sophie.steculorum@sf.mpg.de
SUMMARY:Developmental Programming of Hypothalamic Feeding Circuits: Talk b
y Sebastien Bouret\, PhD\, Children's Hospital\, LA
URL;VALUE=URI:https://www.sf.mpg.de/events/7811/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7581/1747887
DTSTART:20161128T130000Z
DTEND:20161128T140000Z
CLASS:PUBLIC
CREATED:20161104T161450Z
DESCRIPTION: The main interests of our work are the mechanisms underlying m
etabolic diseases\, primarily obesity and insulin resistance. Mammals have
two types of fat: brown and white\, with opposing functions. Main role of
the brown fat is to burn lipids and sugars to produce heat. Brown fat cel
ls also emerge in the subcutaneous adipose tissue (named beige cells) in r
esponse to cold\, a process known as browning. Promotion of increased brow
n fat development in humans and experimental mice leads to increased energ
y expenditure and lean and healthy phenotype without causing dysfunction i
n other tissues\, suggesting the manipulation of the fat stores as an impo
rtant therapeutic objective. The gut microbiota co-develops with the host
and its composition is influenced by several physiological changes\, which
affect the whole-body metabolism and energy balance. With our integrative
research program we are aiming to understand the mechanisms of white adip
ose tissue browning and the intestinal plasticity in regulating metabolic
homeostasis and development of metabolic diseases from the gut microbiota
related perspective.\nSpeaker: Prof. Mirko Trajkovski
LAST-MODIFIED:20161104T161712Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Gut microbiota and energy homeostasis: Talk by Prof. Mirko Trajkovs
ki
URL;VALUE=URI:https://www.sf.mpg.de/events/7581/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7657/1747887
DTSTART:20161128T090000Z
DTEND:20161128T100000Z
CLASS:PUBLIC
CREATED:20161110T154338Z
DESCRIPTION:Speaker: Henning Fenselau\, PhD
LAST-MODIFIED:20161110T154355Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Melanocortin-driven plasticity of hypothalamic feeding circuits :
Talk by Henning Fenselau\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/7657/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7519/1747887
DTSTART:20161114T130000Z
DTEND:20161114T140000Z
CLASS:PUBLIC
CREATED:20161026T141231Z
DESCRIPTION:Speaker: Prof. Markus Schwaninger\, MD
LAST-MODIFIED:20161026T142406Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Brain barriers in metabolic regulation: Talk by Prof. Markus Schwan
inger\, Uni Lübeck
URL;VALUE=URI:https://www.sf.mpg.de/events/7519/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/6669/1747887
DTSTART;VALUE=DATE:20161110
DTEND;VALUE=DATE:20161111
CLASS:PUBLIC
CREATED:20160922T133124Z
DESCRIPTION:Speaker: Diverse
LAST-MODIFIED:20161017T121906Z
LOCATION:MPI for Biology of Ageing\, Room: Lecture Hall
ORGANIZER;CN=Cologne Graduate School:mailto:dmorick@age.mpg.de
SUMMARY:5th Graduate Symposium Cologne Graduate School of Ageing Research:
5th Graduate Symposium Cologne Graduate School of Ageing Research
URL;VALUE=URI:https://www.sf.mpg.de/events/6669/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/7472/1747887
DTSTART:20161031T130000Z
DTEND:20161031T140000Z
CLASS:PUBLIC
CREATED:20161019T153555Z
DESCRIPTION:Speaker: Prof. Dr. phil So Young Park
LAST-MODIFIED:20161019T153555Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Food & Decision Making in humans: what is the link?: Talk by Prof.
So Young Park
URL;VALUE=URI:https://www.sf.mpg.de/events/7472/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/6809/1747887
DTSTART:20161025T120000Z
DTEND:20161025T130000Z
CLASS:PUBLIC
CREATED:20161006T135044Z
DESCRIPTION:Speaker: Dr. Andrew Hoy
LAST-MODIFIED:20161006T143005Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sarah Turpin-Nolan:mailto:ismene.karakasilioti@sf.mpg.de
SUMMARY:Breast Cancer Swimming in a Sea of Lipid: On a voyage to discover t
he link between obesity and breast cancer: Talk by Dr. Andrew Hoy\, Unive
rsity of Sydney
URL;VALUE=URI:https://www.sf.mpg.de/events/6809/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/6577/1747887
DTSTART:20160926T120000Z
DTEND:20160926T130000Z
CLASS:PUBLIC
CREATED:20160913T141342Z
DESCRIPTION:Speaker: Dr. Henry Evrard
LAST-MODIFIED:20160913T141342Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Insular cortex: a neuroanatomical insight into interoception\, emo
tion\, and self-awareness : Talk by Henry Evrard\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/6577/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/6310/1747887
DTSTART:20160829T120000Z
DTEND:20160829T130000Z
CLASS:PUBLIC
CREATED:20160815T115555Z
DESCRIPTION:Brown adipose tissue (BAT) needs to dissipate vast amounts ofin
tracellular and circulating nutrients to sustain its exceptional oxidative
metabolic activity for thermogenesis\, and in doing so BAT activity exerts
beneficial metabolic effects on obesity\, insulin resistance andatheroscle
rosis. Identifying factors that protect adipocytes from metabolicstress du
ring the adaptation to cold and obesity may hold great potentialtowards th
erapeutic approaches for metabolic diseases. As the dramaticmetabolic chan
ges in BAT not only involve dissipation of energy-rich nutrientsbut also t
he de novo synthesis of new proteins\, lipids and cellular organelles\,ada
ptation to cold or excess nutrients might require special mechanisms forin
creased quality control of these metabolic processes. While the endoplasmi
c reticulum (ER) is a critical organelle formetabolic homeostasis\, the me
chanisms that mediate adaptation of the ER inadipocytes are unclear. We wi
ll discuss novel insight into the molecularmechanisms guarding brown fat a
gainstmetabolic stress in cold and obesity. In particular\, we will focus
on theunfolded protein response and ER-associated protein degradation as t
he mostcritical pathways by which the ER responds to increased metabolic d
emand anddiscuss how these are engaged in brown adipocytes. In this contex
t\, we haveidentified Nfe2l1\, also known as Nrf1\, as a novel regulator o
f ER homeostasisin BAT. Using in vitro systems and mouse models we will ad
dress thephysiological\, pathological and translational relevance of Nfe2l
1/Nrf1 for the adaptationof BAT to cold and obesity.\nSpeaker: Dr. Alexand
er Bartelt
LAST-MODIFIED:20160815T120325Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Mechanisms guarding brown fat against metabolic stress in cold and
obesity: Talk by Dr. Alexander Bartelt
URL;VALUE=URI:https://www.sf.mpg.de/events/6310/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/6248/1747887
DTSTART:20160812T120000Z
DTEND:20160812T130000Z
CLASS:PUBLIC
CREATED:20160726T162907Z
DESCRIPTION:Speaker: Denis Burdakov\, PhD
LAST-MODIFIED:20160726T162932Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Deciphering dynamics and connectivity of brain orexin cells: Talk b
y Denis Burdakov\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/6248/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/5626/1747887
DTSTART:20160613T120000Z
DTEND:20160613T130000Z
CLASS:PUBLIC
CREATED:20160525T142516Z
DESCRIPTION:Speaker: Dr. Anthony Don
LAST-MODIFIED:20160525T142637Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Sarah Turpin-Nolan:mailto:Sarah.Turpin-Nolan@sf.mpg.de
SUMMARY:Developing ceramide synthase inhibitors for insulin resistance and
neurodegenerative disease : Talk by Anthony Don\, University of New South
Wales\, Sydney
URL;VALUE=URI:https://www.sf.mpg.de/events/5626/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/5574/1747887
DTSTART:20160603T120000Z
DTEND:20160603T130000Z
CLASS:PUBLIC
CREATED:20160520T143738Z
DESCRIPTION:Change notice: CANCELLED\nSpeaker: Anne Schaefer\, MD\, PhD
LAST-MODIFIED:20160531T142142Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Epigenetic control of neurodegeneration: Talk by Anne Schaefer\, MD
\, PhD
URL;VALUE=URI:https://www.sf.mpg.de/events/5574/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/5523/1747887
DTSTART:20160527T120000Z
DTEND:20160527T130000Z
CLASS:PUBLIC
CREATED:20160512T163650Z
DESCRIPTION:Speaker: Matthew S. Rodeheffer\, PhD
LAST-MODIFIED:20160512T171311Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Understanding how we get fat: Dietary regulation of adipocyte prec
ursors: Talk by Matthew Rodeheffer\, PhD\, Yale University
URL;VALUE=URI:https://www.sf.mpg.de/events/5523/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/5363/1747887
DTSTART:20160426T120000Z
DTEND:20160426T130000Z
CLASS:PUBLIC
CREATED:20160422T115517Z
DESCRIPTION:Speaker: Prof. Ronald Kahn
LAST-MODIFIED:20160422T115520Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Insulin action on the brain: Role in metabolism and brain function
: Talk by Prof. Ronald Kahn
URL;VALUE=URI:https://www.sf.mpg.de/events/5363/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/4524/1747887
DTSTART:20160425T120000Z
DTEND:20160425T130000Z
CLASS:PUBLIC
CREATED:20160302T162329Z
DESCRIPTION:Speaker: Tatiana Korotkova\, PhD
LAST-MODIFIED:20160302T162736Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:" To eat? To sleep? To run? Coordination of innate behaviors by la
teral hypothalamus" : Talk by Tatiana Korotkova\, PhD\, Leibniz Institut f
ür Molekulare Pharmakologie
URL;VALUE=URI:https://www.sf.mpg.de/events/4524/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/4408/1747887
DTSTART:20160321T130000Z
DTEND:20160321T140000Z
CLASS:PUBLIC
CREATED:20160216T165446Z
DESCRIPTION:Speaker: Prof. Dr. Christian Wolfrum
LAST-MODIFIED:20160302T162803Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Mechanisms of brown and white fat formation: Talk by Prof. Dr. Chri
stian Wolfrum\, ETH Zürich
URL;VALUE=URI:https://www.sf.mpg.de/events/4408/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/4405/1747887
DTSTART:20160229T130000Z
DTEND:20160229T140000Z
CLASS:PUBLIC
CREATED:20160215T173320Z
DESCRIPTION:The survival of an organism relies on its ability to promptly\,
effectively and reproducibly communicate with brain networks that control
food intake and energy homeostasis. To achieve this\, circulating factors
of hunger and satiety reflecting nutrient availability must cross the blo
od-brain barrier (BBB) to reach effectors neurons. A defect in this proces
s invariably leads to uncontrolled body weight. Here I will discuss the ke
y role played in this process by a peculiar type of glial cells named tany
cytes\, which have their cell bodies lining the floor of the third ventric
le and their endfeet contacting the pial surface of the brain. Recent stud
ies indeed suggest that tanycytes\, besides regulating hypothalamic BBB pl
asticity according to nutrient status\, capture metabolic signals such as
leptin from the bloodstream and transport them towards their cell body for
release into the cerebrospinal fluid. Blockade of this conduit for periph
eral metabolic factors into the brain of obese individuals is thought to c
ontribute to the pathophysiology of central hormonal resistance.\nSpeaker:
Dr. Vincent Prevot
LAST-MODIFIED:20160215T173836Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Tanycytes: the Hypothalamic Hyperdrive for Metabolic Hormones : Tal
k by Vincent Prevot\, University of Lille\, France
URL;VALUE=URI:https://www.sf.mpg.de/events/4405/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/4319/1747887
DTSTART:20160215T130000Z
DTEND:20160215T140000Z
CLASS:PUBLIC
CREATED:20160128T172223Z
DESCRIPTION:Speaker: Scott Sternson\, PhD
LAST-MODIFIED:20160129T231726Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:The molecular and systems neuroscience of hunger: Talk by Scott Ste
rnson\, PhD\, Janelia Research Campus
URL;VALUE=URI:https://www.sf.mpg.de/events/4319/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/4354/1747887
DTSTART:20160211T130000Z
DTEND:20160211T140000Z
CLASS:PUBLIC
CREATED:20160205T142002Z
DESCRIPTION:Speaker: Stefanie Brassen\, PhD
LAST-MODIFIED:20160205T142042Z
LOCATION:MPI for Metabolism Research\, Gleueler Strasse 50\, 50931 Köln\,
Room: Seminar room 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:bruening@sf.mpg.de
SUMMARY:Reward and cognitive control in aging: Talk by Stefanie Brassen\, U
niversity Medical Center Hamburg-Eppendorf
URL;VALUE=URI:https://www.sf.mpg.de/events/4354/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/3879/1747887
DTSTART:20160111T130000Z
DTEND:20160111T143000Z
CLASS:PUBLIC
CREATED:20151223T133122Z
DESCRIPTION:Engineering of the mouse germline to create targeted mutants is
a key technology for biomedical research. We use an expedite approach for
the generation of mouse mutants by microinjection of engineered\, sequenc
e-specific nucleases into one-cell embryos. Such nucleases create targeted
double-strand breaks (DSBs) and stimulate DNA repair by non-homologous en
d joining (NHEJ) or homology directed repair (HDR). NHEJ religates the ope
n ends\, frequently leading to frameshift (knockout) mutations by the loss
of nucleotides\, whereas HDR enables the insertion of targeted (knockin)
mutations from gene targeting vectors or oligonucleotides as repair templa
tes. By this means mutant knockout and knockin founders are identified 7 w
eeks after embryo injections\, enabling the fast establishment of mutant l
ines. Three nuclease generations\, ZFNs\, TALENs and the CRISPR/Cas9 syste
m were validated in recent years for direct mutagenesis in embryos. In par
ticular\, CRISPR/Cas9 enables the generation of knockout and knockin allel
es at frequencies of up to 40% and 10%\, respectively\, among pups derived
from embryo injections. Nevertheless\, the dominance of NHEJ versus HDR r
equires further improvement. To tackle this problem we established `traffi
c light´ reporter lines indicating DSB repair by NHEJ or HDR through the
expression of red or green fluorescent proteins. To enhance HDR\, we suppr
essed NHEJ key molecules by gene silencing\, by the inhibitor SCR7 or by t
he adenoviral proteins E1B55K and E4orf6. In cell lines\, SCR7 or the knoc
kdown of KU70 and DNA Ligase IV promotes the efficiency of HDR up to 5-fol
d. Coexpression of the DNA Ligase IV degrading E1B55K and E4orf6 proteins
improves the efficiency of HDR up to 8-fold and essentially abolishes NHEJ
repair. We are presently using TLR transgenic mice to enhance HDR repair
of CRISPR/Cas-induced DSBs by NHEJ suppression in early embryos and somati
c cells to optimize the generation of precisely targeted alleles in vivo.\
nSpeaker: Dr. Ralf Kühn
LAST-MODIFIED:20160129T231633Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Editing of mouse and human genomes using CRISPR/Cas : Talk by Dr. R
alf Kühn\, Max Delbrück Center\, Berlin
URL;VALUE=URI:https://www.sf.mpg.de/events/3879/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/3633/1747887
DTSTART:20151130T130000Z
DTEND:20151130T150000Z
CLASS:PUBLIC
CREATED:20151126T220541Z
DESCRIPTION:Speaker: Prof. Dr. Nikolaus Rajewsky
LAST-MODIFIED:20160129T231708Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Dr. Jan-Wilhelm Kornfeld:mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:Regulatory RNAs: Regulatory RNAs
URL;VALUE=URI:https://www.sf.mpg.de/events/3633/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/2490/1747887
DTSTART:20150924T120000Z
DTEND:20150924T130000Z
CLASS:PUBLIC
CREATED:20150910T140251Z
DESCRIPTION:Speaker: Prof. Dr. Hubert Preissl
LAST-MODIFIED:20160129T231740Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Prof. Jens Brüning:mailto:
SUMMARY:Imaging human brain insulin sensitivity over the lifespan
URL;VALUE=URI:https://www.sf.mpg.de/events/2490/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/2489/1747887
DTSTART:20150911T100000Z
DTEND:20150911T110000Z
CLASS:PUBLIC
CREATED:20150910T134641Z
DESCRIPTION:Speaker: Prof. Alain Dagher
LAST-MODIFIED:20160129T231752Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Dr. Marc Tittgemeyer:mailto:marc.tittgemeyer@sf.mpg.de
SUMMARY:Brain Endophenotypes of Obesity
URL;VALUE=URI:https://www.sf.mpg.de/events/2489/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/2332/1747887
DTSTART:20150831T130000Z
DTEND:20150831T140000Z
CLASS:PUBLIC
CREATED:20150814T124053Z
DESCRIPTION:Speaker: Dr. Siegfried Ussar
LAST-MODIFIED:20160129T231803Z
LOCATION:MPI for Metabolism Resarch\, Room: Seminar 1
ORGANIZER;CN=Dr. Thomas Wunderlich:mailto:thomas.wunderlich@sf.mpg.de
SUMMARY:Intestinal regulators of whole body metabolism
URL;VALUE=URI:https://www.sf.mpg.de/events/2332/1747887
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260312T131129Z
UID:https://www.sf.mpg.de/events/2284/1747887
DTSTART:20150824T064500Z
DTEND:20150824T153000Z
CLASS:PUBLIC
CREATED:20150730T153749Z
DESCRIPTION:With the advent of modern sequencing techniques\, regulatory RN
A biology is gaining significant focus in myriads of avenues ranging from
control of development to ageing and ageing-associated diseases. We bring
together a group of young\, internationally acclaimed scientists specializ
ing in diverse aspects of RNA biology ranging from novel mechanisms of alt
ernative splicing to single cell RNA sequencing. This will be a great oppo
rtunity to familiarize with the latest developments in regulatory RNA biol
ogy.\nIn order to facilitate easy and convenient scientific exchange\, thi
s symposium is free and registration is not required.
LAST-MODIFIED:20150801T231350Z
LOCATION:CECAD Research Center\, Joseph-Stelzmann-Str. 26\, 50931 Cologne
ORGANIZER;CN="Organizers: Roman-Ulrich Müller, Jan-Wilhelm Kornfeld and Le
o Kurian":mailto:jan-wilhelm.kornfeld@sf.mpg.de
SUMMARY:NonCode 2015 - CECAD Mini-Symposium on regulatory RNAs: NonCode 201
5 - CECAD Mini-Symposium on regulatory RNAs
URL;VALUE=URI:https://www.sf.mpg.de/events/2284/1747887
END:VEVENT
END:VCALENDAR