Publications of Eckhard Mandelkow

Pir, G. J.; Choudhary, B.; Mandelkow, E.; Mandelkow, E.-M.: Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model. Molecular Neurodegeneration 11 (1), 96 (2016)

Wang, Y.; Mandelkow, E.: Tau in physiology and pathology. Nature Reviews Neuroscience 17 (1), pp. 5 - 21 (2016)

Pickhardt, M.; Neumann, T.; Schwizer, D.; Callaway, K.; Vendruscolo, M.; Schenk, D.; St. George-Hyslop, P.; Mandelkow, E.-M.; Dobson, C.; McConlogue, L. et al.; Mandelkow, E.; Toth, G.: Identification of small molecule inhibitors of tau aggregation by targeting monomeric tau as a potential therapeutic approach for tauopathies. Current Alzheimer Research 12 (9), pp. 814 - 828 (2015)

Shammas, S. L.; Garcia, G. A.; Kumar, S.; Kjaergaard, M.; Horrocks, M. H.; Shivji, N.; Mandelkow, E.-M.; Mandelkow, E.; Klenerman, D.: A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications 6, 7025 (2015)

Kumar, S.; Tepper, K.; Kaniyappan, S.; Biernat, J.; Wegmann, S.; Mandelkow, E.-M.; Müller, D. J.; Mandelkow, E.: Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. Journal of Biological Chemistry 289 (29), pp. 20318 - 20332 (2014)

Zempel, H.; Mandelkow, E.: Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease. Trends in Neurosciences 37 (12), pp. 721 - 732 (2014)

Bulic, B.; Pickhardt, M.; Mandelkow, E.: Progress and developments in tau aggregation inhibitors for Alzheimer disease. Journal of Medicinal Chemistry 56 (11), pp. 4135 - 4155 (2013)

Messing, L.; Decker, J. M.; Joseph, M.; Mandelkow, E.; Mandelkow, E.-M.: Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of Aging 34 (5), pp. 1343 - 1354 (2013)

Wegmann, S.; Medalsy, I. D.; Mandelkow, E.; Müller, D. J.: The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proceedings of the National Academy of Sciences of the United States of America 110 (4), pp. E313 - E321 (2013)

Fatouros, C.; Pir, G. J.; Biernat, J.; Koushika, S. P.; Mandelkow, E.; Mandelkow, E.-M.; Schmidt, E.; Baumeister, R.: Inhibition of Tau aggregation in a novel caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Human Molecular Genetics 21 (6), pp. 3587 - 3603 (2012)

Jones, E. M.; Dubey, M.; Camp, P. J.; Vernon, B. C.; Biernat, J.; Mandelkow, E.; Majewski, J.; Chi, E. J.: Interaction of Tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry 51 (12), pp. 2539 - 2550 (2012)

Wang, Y.; Mandelkow, E.: Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society Transactions 40 (4), pp. 644 - 652 (2012)