Talk by Giuseppe D'Agostino, PhD

Neuronal Circuits Controlling Energy Metabolism Beyond Appetite Regulation

Date: Nov 14, 2025
Time: 10:00 AM - 11:00 AM (Local Time Germany)
Speaker: Giuseppe D'Agostino, PhD
Giuseppe (Peppe) D'Agostino is a Group Leader at the University of Manchester, Division of Diabetes, Endocrinology and Gastroenterology, and he is a member of the Lydia Becker Institute of Immunology and Inflammation and the Geoffrey Jefferson Brain Research Centre. A pharmacologist by training, Peppe earned his PhD in Neuropharmacology from the University of Naples, Italy, and pursued further research training at Yale University (USA), the University of Cambridge, and the University of Aberdeen. In 2017, he was awarded a Medical Research Council fellowship to establish his independent research group. In 2019, his laboratory relocated to the University of Manchester In 2019, where in 2023 became Senior Lecturer (Associate Professor). His group focuses on neuronal circuits that control appetite and fuel metabolism under both homeostatic and pathological conditions, employing genetics, systems neuroscience, and integrative physiology approaches.
Location: MPI for Metabolism Research, Gleueler Strasse 50, 50931 Köln
Room: Seminar room 1
Host: Prof. Jens Brüning
Contact: klingenberg@sf.mpg.de
Topic: Discussion and debate formats, lectures

Brain circuits that sense energy do far more than drive appetite. This talk explores how hypothalamic and brainstem networks orchestrate whole-body metabolism, managing a critical trade-off between immune readiness and energy conservation. This highlights an emerging framework of how the brain dynamically matches whole-body physiology to its perceived energy status and prioritizes tissue maintenance under changing nutritional states.